A5019608105- Microwave Engineering and Waveguides
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Cholesterol and Lipid Metabolism
- Antenna Design and Analysis
- Nuclear Structure and Function
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Advanced Antenna and Metasurface Technologies
- Liver physiology and pathology
- Immune cells in cancer
- Antenna Design and Optimization
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
- Photosynthetic Processes and Mechanisms
- Cardiovascular Disease and Adiposity
- Peptidase Inhibition and Analysis
Hebei Medical University
2017-2025
Qilu University of Technology
2024-2025
The University of Texas Health Science Center at Houston
2024-2025
Dalian Maritime University
2023-2024
Liaoning Technical University
2022-2024
Nanjing Drum Tower Hospital
2024
North China University of Science and Technology
2021-2023
Liaoning University
2023
Ministry of Education of the People's Republic of China
2015-2022
North China Electric Power University
2022
Abstract Background Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma Coptis, is widely used in the treatment of hyperlipidemia (HLP) China. At present, efficacy BBR against HLP relatively clear, but there are few researches on its mechanism. The purpose this study was to evaluate potentially beneficial role hamster models, as well investigate possible mechanisms and potential lipid biomarkers combination with network pharmacology. Methods model induced by high-fat diet....
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a trait. Hamsters, like humans, have the cholesteryl ester transfer protein, intestine-only ApoB editing and low hepatic cholesterol synthesis. Here, we generated Ldlr-ablated hamsters using CRISPR/Cas9 technology. Homozygous KO on chow diet developed with as lipoprotein spontaneous...
Abstract Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is the most severe form of human and caused by loss-of-function mutations in BSCL2/seipin gene. Exactly how seipin may regulate adipogenesis remains unclear. A recent study vitro suggested that function to inhibit activity glycerol-3-phosphate acyltransferases (GPATs), increased GPAT be responsible for defective under deficiency. Here we generated Seipin−/−Gpat3−/− mice, which had mild but significant recovery white adipose...
Objective— Recently, we demonstrated that scavenger receptor type BI (SR-BI), a high-density lipoprotein (HDL) receptor, was expressed on murine hematopoietic stem/progenitor cells (HSPC) and infusion of reconstituted HDL purified human apolipoprotein A-I (apoA-I) suppressed HSPC proliferation. We hypothesized SR-B1 expression is required for the observed antiproliferative effects HSPC. Approach Results— SR-BI–deficient (SR-BI −/− ) mice wild-type controls were fed chow or high-fat diet...
Hepatocytes Foxo1 controls the crosstalk between hepatocytes, macrophages, and HSC, via regulating TGF-β1 expression, to promote liver fibrosis.Hepatic FoxO1 may be a therapeutic target for prevention treatment of fibrosis. Background & Aims:The O-class forkhead transcription factor is crucial mediating insulin→PI3K→Akt signaling governs diverse cellular processes.However, role hepatocyte in fibrosis has not been well established.In his study, we investigated uncovered underlying...
The endocardium plays a pivotal role in governing myocardial development, and understanding the intrinsic regulatory insights will help apprehend pathological cardiomyopathy. Glycerol-3-phosphate acyltransferase 4 (GPAT4) is an endoplasmic reticulum (ER) membrane anchored protein. While of GPAT4 glycerophospholipid biosynthesis well established, its function ER less explored. Here, we generate Gpat4 global tissue-specific knockout mice identify essential endocardial development. Deficiency...
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)<i>δ</i> inhibitors in B-cell malignancies is hampered by hepatotoxicity, requiring dose reduction, treatment interruption, and/or discontinuation therapy. In addition, potential molecular mechanisms which resistance to this class drugs occurs have not been investigated. Parsaclisib (INCB050465) a potent and selective next-generation PI3K<i>δ</i> inhibitor that differs structure from has shown encouraging anti–B-cell tumor...
Abstract AGPATs (1-acylglycerol-3-phosphate O -acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic (PA), a key step in glycerol-3-phosphate pathway for synthesis phospholipids and triacylglycerols. AGPAT2 is only AGPAT isoform whose loss-of-function mutations cause severe human congenital generalized lipodystrophy. Paradoxically, deficiency known dramatically increase level its product, PA. Here, we find that impairs biogenesis growth lipid droplets. We...
Atherosclerosis-prone apolipoprotein E (apoE) or low-density lipoprotein receptor (LDL-R) knockout (KO) mice are generally resistant to developing coronary atherosclerosis (CA) and ischemic heart disease (IHD). However, studies have demonstrated the occurrence of spontaneous CA IHD in scavenger class B type 1 (SR-BI)/apoE double KO (dKO) mice, which suggests that SR-BI could be a potential target for prevention therapy IHD. This possibility was later investigated SR-BI/LDL-R dKO but no signs...
Abstract In the process of inflammatory activation, macrophages exhibit lipid metabolism disorders and accumulate droplets. Kupffer cells (KCs) are resident hepatic macrophage with critical defense functions in pathogenesis several types liver disease. How dysregulated contributes to perturbed KCs remains elusive. Here we report that glycerol-3-phosphate acyltransferase 3 (GPAT3) plays a key role inflammation response. Our findings indicate lipopolysaccharide (LPS)-mediated activation...