A5101525778- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- MicroRNA in disease regulation
- Brain Tumor Detection and Classification
- Neurological diseases and metabolism
- Cancer-related molecular mechanisms research
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Restless Legs Syndrome Research
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Lipid metabolism and disorders
- Botulinum Toxin and Related Neurological Disorders
- Regulation of Appetite and Obesity
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- RNA modifications and cancer
- Genetic Neurodegenerative Diseases
- Circular RNAs in diseases
Shandong Provincial QianFoShan Hospital
2010-2025
Shandong First Medical University
2022-2025
Hebei Medical University
2025
Shandong University
2009-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2023
SleepMed
2019
University of Warwick
2006-2012
Objective: lncRNAs are recently thought to play a significant role in cellular homeostasis during pathological process of diseases by competing inhibiting miRNA function. The aim present study was assess the function long non-coding RNA (lncRNA) MEG3 and its functional interaction with microRNA-181b cerebral ischemic infarct mice hypoxia-induced neurons apoptosis. Methods: To address this question, we performed experiments vivo middle artery occlusion (MCAO) model vitro oxygen-glucose...
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) orexin-2 (OX2R) have been shown to play a role in the regulation of feeding, body weight, energy expenditure. Adipose tissue also contributes significantly maintenance weight by interacting with complex array bioactive peptides; however, there are no data as yet on expression orexin components adipose tissue. We, therefore, analyzed OX1R OX2R human determined functional responses orexin-A orexin-B. mRNA was detected...
Objective The aim of this study was to investigate the correlation between sleep chronotype and metabolic markers further reveal influence on human health. Methods Morningness-Eveningness Questionnaire administered 442 volunteers aged 23–70 years old. divided into morning type (167 cases), neither (224 evening (51 cases). Blood pressure recorded, fasting venous blood samples were collected assess liver function, renal glucose levels, lipid profile, other biochemical parameters. Results 1....
Background As a medium for developing brain-computer interface systems, EEG signals are complex and difficult to identify due their complexity, weakness, differences between subjects. At present, most of the current research on sleep single-channel dual-channel, ignoring relationship different brain regions. Brain functional connectivity is considered be closely related activity can used study interaction areas. Methods Phase-locked value (PLV) construct connection network. The network...
The type 1 corticotropin-releasing hormone receptor (CRH-R1) influences biological responses important for adaptation to stressful stimuli, through activation of multiple downstream effectors. structural motifs within CRH-R1 that mediate G protein and signaling selectivity are unknown. aim this study was gain insights about determinants the third intracellular loop (IC3) human CRH-R1α cAMP ERK1/2 pathways selectivity. We investigated role juxtamembrane regions IC3 by mutating amino acid...
BACKGROUND 5-HT6 receptor (5-HT6R) has pluripotent roles regulating secretion of neurotransmitters. However, whether 5-HT6R is involved in the development vascular dementia (VD) remains unclear. To evaluate role and mechanism VD, this study established a rat VD model to effect selective agonist on expression mRNA neurotransmitter. MATERIAL AND METHODS Eighty healthy male SD rats (7 weeks old) were randomly assigned sham, model, agonist, placebo groups (N=20 each). A was generated by permeant...
Abnormal sleep architecture and white matter hyperintensities (WMHs) may be involved in cognitive impairment. There is little evidence on the connections between WMHs chronic insomnia disorder (CID). Therefore, we evaluated severity of polysomnography parameters as well tests to explore underlying connections. was no significant difference sex, age, or educational attainment (years) two groups. The data showed decreases total time, efficiency, percentage time spent stage nonrapid eye...
Objectives Narcolepsy patients were observed improvements in their academic performance during the COVID-19 home quarantine. Therefore, we aim to investigate influence of sleep behavioral changes on school/work narcolepsy Methods Patients admitted Shandong Provincial Qianfoshan Hospital from Jan 1, 2017 2021 who diagnosed with studied by online questionnaires two different periods (during and 1 year after quarantine), including five aspects: (1) (percentile ranking class/Sheehan Disability...
At present, the etiology of narcolepsy is not fully understood, and it generally believed to be an autoimmune reaction caused by interactions between environmental genetic factors. Human leukocyte antigen (HLA) class II genes are strongly associated with this gene, especially HLA-DQB1*0602/DQA1*0102. In study, we mainly analyzed correlation different genotypes HLA-DQB1*0602/DQA1*0102 clinical manifestations in Chinese patients narcolepsy.
Dopamine,a neurotransmitter ubiquitous in the body fluids,blood,and urine of mammals and humans,is responsible for regulating their functions metabolism.The dopamine system is involved neurobiological mechanisms narcolepsy animals humans.However,researchers have drawn different or even opposite conclusions when measuring level cerebrospinal fluid patients.Studies confirmed that occurrence related to irreversible loss orexins.The autoimmune reaction caused by interactions environmental...
Hereditary spastic paraplegia (HSP) is a group of neurogenetic diseases the corticospinal tract, accompanied by distinct spasticity and weakness lower extremities. Mutations in type 4 (SPG4) gene, encoding spastin protein, are major cause disease. This study reported Chinese family with HSP caused novel mutation SPG4 gene.A 44-year-old male was admitted to our hospital for long-term right limb weakness, leg stiffness, unstable walking. His symptoms gradually worsened, while no obvious muscle...
Abstract Background To investigate the effects of benzodiazepine receptor agonists on cognitive function in patients with chronic insomnia. Method According to history taking hypnotic drugs, they were divided into no medication group (n = 62), benzodiazepines 57) and non‐benzodiazepines 53); all subjects The Pittsburgh Sleep Quality Scale, Epworth Insomnia Severity Index used evaluate their sleep quality, Hamilton Anxiety Depression Scale anxiety depression. conversion test, auditory word...
Objective To investigate the effects of electric stimulation on motor function and expression Rho kinase following cerebral infarction in rats. Methods Acute was modeled adult male Sprague-Dawley ( SD) rats using permanent middle artery occlusion PMCAO) technique. The were randomly divided into sham operation, control, unilateral bilateral groups each group had 36 rats). Electric applied to paralyzed or bilateral) limbs last two groups. Motor recovery examined a beam walking test BWT)...
Objective To investigate the effects of unilateral and bilateral electrical stimulation upper lower limbs on motor function following cerebral infarction expressions microtubule-associated protein-2 (MAP-2) survivin in border zone rats. Methods Adult male Sprague-Dawley (SD) rats were randomly divided into sham operation, control, impaired limb groups (each group included 32 rats). Acute was mimicked using a middle artery occlusion tech-nique. After for 24 h, treated daily with or without...