A5101831472- Neurological Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Nerve injury and regeneration
- Sleep and related disorders
- Eicosanoids and Hypertension Pharmacology
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Traditional Chinese Medicine Analysis
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Microplastics and Plastic Pollution
- Infant Development and Preterm Care
- Neurological Disorders and Treatments
- Polyoxometalates: Synthesis and Applications
- Stress Responses and Cortisol
- Epilepsy research and treatment
Zhengzhou University
2010-2025
Affiliated Hospital of Taishan Medical University
2025
Shandong First Medical University
2025
Hebei Medical University
2023-2025
Boston University
1993-2020
Cleveland Clinic Lerner College of Medicine
2012-2016
Liaoning University
2012-2013
Cleveland Clinic
2012
Icahn School of Medicine at Mount Sinai
2008-2012
Allen Institute for Brain Science
2012
Synaptic reorganization of the dentate gyrus inner molecular layer (IML) is a pathophysiological process that may facilitate seizures in patients with temporal-lobe epilepsy. Two subtypes IML neurons were originally described by Ramón y Cajal (1995), but have not been thoroughly studied. We used two-photon imaging, infrared-differential interference contrast microscopy and patch clamp recordings from rat hippocampal slices to define intrinsic physiology synaptic targets spiny, granule-like...
Intense noise exposure causes hyperactivity to develop in the mammalian dorsal cochlear nucleus (DCN) and inferior colliculus (IC). It has not yet been established whether IC is driven by from extrinsic sources that include DCN or instead maintained independently of this input. We have investigated extent which dependent on input contralateral comparing recordings spontaneous activity noise-exposed control hamsters before after ablation DCN. One group animals was binaurally exposed intense...
Abstract The general organization of neocortical connectivity in rhesus monkey is relatively well understood. However, mounting evidence points to an organizing principle that involves clustered synapses at the level individual dendrites. Several synaptic plasticity studies have reported cooperative interaction between neighboring on a given dendritic branch, which may potentially induce synapse clusters. Additionally, theoretical models predicted such cooperativity advantageous, it greatly...
Motherhood is accompanied by new behaviors aimed at ensuring the wellbeing of offspring. Olfaction plays a key role in guiding maternal during this transition. We studied functional changes main olfactory bulb (OB) mothers mice. Using vivo two-photon calcium imaging, we sensory representation odors mitral cells (MCs). show that MC responses to monomolecular become sparser and weaker mothers. In contrast, biologically relevant are spared from sparsening or strengthen. mixtures range...
Objective The aim of this study was to investigate the correlation between sleep chronotype and metabolic markers further reveal influence on human health. Methods Morningness-Eveningness Questionnaire administered 442 volunteers aged 23–70 years old. divided into morning type (167 cases), neither (224 evening (51 cases). Blood pressure recorded, fasting venous blood samples were collected assess liver function, renal glucose levels, lipid profile, other biochemical parameters. Results 1....
Social interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones stud male that alters neuroendocrine responses to his chemosignals many weeks. The cellular and synaptic correlates pheromonal learning, however, remain unclear. We examined local circuit changes in accessory olfactory bulb (AOB) using targeted ex vivo recordings mating-activated neurons tagged with fluorescent reporter. Imprinting led striking...
The goal of this study was to elucidate the mechanisms protection Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (trade name: Brozopine, BZP) against cerebral ischemia in vivo and vitro. To explore protective effect BZP on focal ischemia-reperfusion injury, we evaluated effects various doses neurobehavioral score, infarction volume, swelling MCAO rats (ischemia for 2 h, reperfusion 24 h). In addition, OGD/R-induced-PC12 cells injury (hypoglycemic medium containing 30 mmol Na2S2O4...
The following two hypotheses regarding diaphragm contractile properties in the perinatal rat were tested. First, there is a major transformation of and fatigue during period between inception inspiratory drive transmission utero birth. Second, muscle develop to functionally match changes occurring phrenic motoneuron electrophysiological properties. Muscle force recordings intracellular end-plate potentials measured by using nerve-diaphragm vitro preparations isolated from rats on embryonic...
The accessory olfactory system controls social and sexual behavior. In the mouse bulb, first central stage of information processing along pathway, projection neurons (mitral cells) display infra-slow oscillatory discharge with remarkable periodicity. physiological mechanisms that underlie this default output state, however, remain controversial. Moreover, whether such rhythmic activity patterns exist in awake behaving mice reflects functional organization bulb circuitry unclear. Here, we...
The aim of the current study was to explore protective effects sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (brand name: brozopine, BZP) in a rat model global cerebral ischemia. established using modified Winocur's method; close postoperative observation conducted at all times. Neurological function detected through prehensile traction and beam-walking test. BZP reduced mortality prolonged survival time rats with ischemia, within 24 h. There decreased rate (60%) Model group, while (3 12...
Aging and neurodegenerative disorders significantly alter both neuronal function morphology. We have shown recently that, if uncompensated by altered ion channel distributions, morphologic changes in aging increase excitability [1]. Different combinations of active conductances can evoke similar firing patterns, giving rise to functional homeostasis. To elucidate possible mechanisms homeostasis the parameter space defined ionic conductances, we utilized thermal random walks identify regions...