A5073874455- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Folate and B Vitamins Research
- Carcinogens and Genotoxicity Assessment
- Nanoplatforms for cancer theranostics
- Vitamin D Research Studies
- Pharmacological Effects and Toxicity Studies
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Advanced Radiotherapy Techniques
University of Toronto
2019-2024
Abstract Background Radiation nanomedicines are nanoparticles labeled with radionuclides that emit α- or β-particles Auger electrons for cancer treatment. We describe here our 15 years scientific journey studying locally-administered radiation further present a view of the nanomedicine landscape by reviewing research reported other groups. Main body Gold were studied initially radiosensitization breast to X-radiation therapy. These 111 In assess their biodistribution after intratumoural vs....
Significance Folates are critical for brain development and function. Abnormalities in folate transport have been implicated a number of childhood neurodevelopmental disorders, including cerebral deficiency syndrome, hereditary malabsorption, autism spectrum disorders. These disorders devastating effects young children, current therapeutic approaches not sufficiently effective. In this study, we demonstrate that functional expression the transporter, reduced carrier, at blood–brain barrier...
In this study, we investigated convection-enhanced delivery (CED) of 23 ± 3 nm gold nanoparticles (AuNPs) labeled with the β-particle-emitting radionuclide 177Lu (177Lu-AuNPs) for treatment orthotopic U251-Luc human glioblastoma multiforme (GBM) tumors in NRG mice. The cytotoxicity vitro 177Lu-AuNPs (0.0-2.0 MBq, 4 × 1011 AuNPs) on cells was also studied by a clonogenic survival assay, and DNA double-strand breaks (DSBs) caused β-particle emissions were measured confocal immunofluorescence...
Triple-negative breast cancer (TNBC) has a high risk for recurrence and metastasis. We studied the effectiveness of Auger electron (AE) radioimmunotherapy (RIT) with antiepidermal growth factor receptor (EGFR) panitumumab conjugated DOTA complexed to 111In ([111In]In-DOTA-panitumumab) preventing metastatic progression after local treatment 231/LM2-4 Luc+ human TNBC tumors in mammary fat pad NRG mice. Prior RIT, primary tumor was resected, margins were treated X-irradiation (XRT; 5 days × 6...
To examine the reliability to model cellular S-values for Auger electron (AE) emitters, 111In, 197Hg and 197mHg with MCNP6 their relative dose deposition in subcellular targets.A cell was defined as four concentric spheres consisting of nucleus (N), cytoplasm (Cy), nuclear membranes (CM, NM) which radionuclides distributed homogeneously. The transport AE, conversion electrons photons were simulated by calculate S values (SN←CM, SN←Cy, SN←NM, SN←N, SCM←CM, SNM←NM). SN←CM, SN←Cy SN←N also...
Our objective was to study convection enhanced delivery (CED) of