A5060584809- Circadian rhythm and melatonin
- Folate and B Vitamins Research
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Biochemical effects in animals
- Multiple Sclerosis Research Studies
- Human Health and Disease
- Anesthesia and Neurotoxicity Research
- Biochemical Acid Research Studies
- Metabolism and Genetic Disorders
- GDF15 and Related Biomarkers
- Reproductive System and Pregnancy
- Redox biology and oxidative stress
- Stress Responses and Cortisol
- Neurological Disorders and Treatments
- Neuroscience of respiration and sleep
- Chemical and Physical Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics, Aging, and Longevity in Model Organisms
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Nerve injury and regeneration
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
St. Petersburg Institute of Bioregulation and Gerontology
2007-2025
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2016-2025
Academy of Medical Sciences
2008-2014
Russian Academy of Sciences
1999-2014
The article presents an analysis of the results many years research devoted to study biological activity peptide bioregulators at molecular, cellular and tissue levels, as well level organism. efficacy their mechanism action allowed famous Russian gerontologist Vladimir Khavinson propose concept regulation gene expression protein synthesis. He developed introduced technology obtaining active preparations from animal tissues also synthesized short peptides with targeted tissue-specific...
Ten heat-sensitive patients with MS were randomly allocated in a cross-over study to wear cooling garment for 60 minutes at 7 degrees C (active cooling) and 26 (sham cooling). In contrast sham cooling, active improved fatigue postural stability eyes closed muscle strength. There was no decrease tympanic temperature, but associated 41% mean leukocyte nitric oxide (NO) production (p = 0.004). This effect on NO could be relevant because it blocks conduction demyelinated axons.
Oxidative stress has been implicated in the pathophysiology of multiple sclerosis (MS), but its relation to disease progression is uncertain. To evaluate relationship plasma lipid peroxidation with disability MS, we measured blood fluorescent products (PFLPP) levels 23 patients RRMS a benign course, 32 secondary progressive 24 primary MS and 30 healthy controls. None had relapse within previous 3 months. Progression was evaluated during follow‐up period 5 years by Expanded Disability Status...
From the age of 6 months until their natural deaths, female CBA mice were given melatonin with drinking water (20 mg/l) for 5 consecutive days every month. Intact served as controls. The results this study show that consumption did not significantly influence food consumption, but it increase body weight older mice; physical strength or presence fatigue; decreased locomotor activity and temperature; inhibited free radical processes in serum, brain, liver; slowed down age-related...
Maternal hyperhomocysteinemia causes the disruption of placental blood flow and can lead to serious disturbances in formation offspring’s brain. In present study, effects prenatal (PHHC) on neuronal migration, neural tissue maturation, expression signaling molecules rat fetal brain were described. was induced female rats by per os administration 0.15% aqueous methionine solution period days 4–21 pregnancy. Behavioral tests revealed a delay PHHC male pups maturing. Ultrastructure both...
Maternal hyperhomocysteinemia is one of the common complications pregnancy that causes offspring cognitive deficits during postnatal development. In this study, we investigated effect prenatal (PHHC) on inflammatory, glial activation, and neuronal cell death markers in hippocampus infant rats. Female Wistar rats received L-methionine (0.6 g/kg b.w.) by oral administration pregnancy. On days 5 20, offspring’s was removed to perform histological biochemical studies. After PHHC, exhibited...
Background The reason for increased peripheral blood leukocyte (PBL) nitric oxide (NO) production in patients with multiple sclerosis (MS) is unknown. Objective To investigate whether PBL NO related to measures of oxidative stress. Methods nitrite, diene conjugates (DC, a measure undergone stress), antiradical activity (ARA) and antioxidant acitvity (AOA) were measured 35 healthy control persons 80 MS. We investigated the correlation these partial analysis, age as variable. Results There was...
The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) induced by oxidative stress stimulated receptor-dependent or -independent processes. At the same time, decreases necrotic cell death measured propidium iodide test. protective effect is accompanied with a delayed time course ERK 1/2 activation modification cycle. Because ROS mortality...
<i>Background:</i> Caloric restriction (CR) is the only treatment known to substantially prolong both average and maximal life span in experimental animals. Interventions that mimic certain effects of CR could be potential anti-aging treatments humans. Drugs which reduce appetite (anorexiants) represent one class candidate treatments. Agents glucose utilization by organism also another mimetics. <i>Objective:</i> In our study, we addressed following questions: (1)...
Neuron-specific enolase (NSE) and brain-derived neurotrophic factor (BDNF) levels in umbilical cord blood full-term newborns with asymmetrical intrauterine growth retardation resulted from chronic placental insufficiency have been studied. Not only a 2.0–2.5-fold increase the NSE level, but also reduction BDNF were observed, indicating brain damage combined lack of adequate compensatory capabilities. With an duration fetal development under conditions hypoxia, degree to neuronal structures...
<b><i>Background:</i></b> Nitric oxide (NO) may play a role in tissue destruction and axonal degeneration multiple sclerosis (MS). <b><i>Objective:</i></b> To investigate NO production by peripheral blood leukocytes (PBL) patients with benign progressive course of MS. <b><i>Methods:</i></b> PBL were isolated from 25 MS (BMS), 33 secondary (SPMS), 21 primary (PPMS), 29 healthy individuals. Leukocyte supernatants assayed for nitrite concentration, which is an index generation, using the Griess...
BACKGROUND: The high frequency of neurological and mental diseases in children who had intrauterine retardatiojn development indicates the need to study specific markers disorders fetal brain functional development, particular, state serotonergic system, which plays a key role morpho-functional early ontogenesis.
 AIM: To content serotonin full-term newborns with delay comparison quantitative qualitative characteristics sleep.
 MATERIALS AND MЕTHODS: main group consisted 26...