A5076424715- Multiple Sclerosis Research Studies
- Muscle Physiology and Disorders
- Systemic Sclerosis and Related Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Exercise and Physiological Responses
- Cerebral Palsy and Movement Disorders
- Employment and Welfare Studies
- Advanced Sensor and Energy Harvesting Materials
- Neurogenetic and Muscular Disorders Research
- Muscle activation and electromyography studies
- Effects of Vibration on Health
- Biotin and Related Studies
- Transcranial Magnetic Stimulation Studies
- Workplace Health and Well-being
- Heart Failure Treatment and Management
- Prosthetics and Rehabilitation Robotics
- Nuclear Structure and Function
- Children's Physical and Motor Development
- Powdery Mildew Fungal Diseases
- Workaholism, burnout, and well-being
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circadian rhythm and melatonin
- Pulmonary Hypertension Research and Treatments
- Autoimmune and Inflammatory Disorders Research
Medisch Centrum Leeuwarden
2016-2024
University of Groningen
2004-2005
<h3>Background</h3> Prednisone treatment is used to prolong ambulation in patients with Duchenne muscular dystrophy (DMD). However, since severe adverse effects often accompany prednisone treatment, it debatable whether the benefits of outweigh its effects. <h3>Objectives</h3> To study on muscle function and determine extent steroid-related their influence quality life ambulant DMD. <h3>Design</h3> A randomized, placebo-controlled, crossover trial 6 months treatment: or placebo (0.75 mg/kg...
Ten heat-sensitive patients with MS were randomly allocated in a cross-over study to wear cooling garment for 60 minutes at 7 degrees C (active cooling) and 26 (sham cooling). In contrast sham cooling, active improved fatigue postural stability eyes closed muscle strength. There was no decrease tympanic temperature, but associated 41% mean leukocyte nitric oxide (NO) production (p = 0.004). This effect on NO could be relevant because it blocks conduction demyelinated axons.
Cognitive functioning has been linked to employment outcomes in multiple sclerosis (MS) cross-sectional studies. Longitudinal studies are however lacking and previous did not extensively examine executive functioning. We examined whether baseline cognitive predicts a change status after 2 years, while taking into account mood, fatigue disability level. A total of 124 patients with relapsing-remitting MS (pwMS) 60 healthy controls were included. They underwent neurological neuropsychological...
PurposeTo investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, work-related factors in people with multiple sclerosis (MS).Methods170 employed MS underwent yearly neurological neuropsychological examinations to assess MS-related disability cognitive functioning. Additionally, they completed questionnaires assessing depression, anxiety, fatigue, complaints, workplace support coping. Multilevel models for change were fitted examine...
The aim of this study was to examine whether work capabilities differ between workers with Multiple Sclerosis (MS) and from the general population. second investigate capability set related health outcomes. A total 163 MS MS@Work population were matched for gender, age, educational level working hours. All participants completed online questionnaires on demographics, functioning. Capability Set Work Questionnaire used explore a seven values is considered valuable (A), enabled in context (B),...
Symptoms of anxiety and depression affect the daily life people with multiple sclerosis (MS). This study examined work difficulties their relationship anxiety, coping style in MS.219 employed MS (median age = 43 years, 79% female) completed questionnaires on depression, style, demographics difficulties, underwent a neurological examination. Two regression analyses were performed as dependent variable either or continuous independent variables. Coping age, gender, educational level,...
Multiple sclerosis (MS) is a chronic disorder of the central nervous system with an unpredictable disease course. Life partners often become caregivers, which can be both rewarding and challenging, as caregiver's physical mental health negatively affected. Previous studies on caregiver strain focused caregivers persons MS relatively high disability levels, while may already experienced by life living mildly disabled MS.The current study examines factors associated in mild due to...
Job loss is common in multiple sclerosis (MS) and known to exert a negative effect on quality of life. The process leading up job typically includes work events, productivity losses need for accommodations. By using active coping strategies may be prevented or delayed.Our goal was examine events accommodations relation employed relapsing-remitting MS patients.Ninety-seven patients (77% females; 21-59 years old) completed questionnaires concerning the patient's situation, strategies,...
Muscle strength is decreased in adults with pulmonary arterial hypertension (PAH). We aim to investigate muscle children PAH relation a cohort of healthy children, and correlations disease severity markers. This prospective study included aged 4-18 years, who visited the Dutch National Referral Center for Pulmonary Hypertension Childhood between October 2015 March 2016. was assessed using handgrip maximum voluntary isometric contractility (MVIC) four peripheral muscles. Dynamic function...
BackgroundRecent studies report deficits in social cognition individuals with multiple sclerosis (MS). Social cognitive skills such as empathy are important for adequate and occupational functioning. Our objectives are: (1) to examine whether differs between MS healthy controls, (2) relations cognitive, psychological functioning.Methods278 (relapsing-remitting subtype) 128 controls from the [email protected] study participated this investigation. The participants completed questionnaires...
Purpose The current study aimed to evaluate the psychometric properties of Dutch version Multiple Sclerosis Work Difficulties Questionnaire-23 (MSWDQ-23).Methods Two hundred and thirty-nine employed persons with multiple sclerosis (MS) 59 healthy controls completed MSWDQ-23. To verify factor structure, a confirmatory analysis was conducted. assess construct validity, MSWDQ-23 scores were correlated measures physical disability, fatigue, cognitive neuropsychiatric problems, depression,...
BackgroundMultiple sclerosis (MS) poses a major threat to sustainable employability. Identifying conditions and factors that promote work participation is of great importance. Our objective was explore the contribution personality traits in explaining occupational functioning MS.Methods241 participants with relapsing-remitting MS (78% female, median age: 42.0 years, EDSS: 2.0) 60 healthy controls (70% 45.0 years) underwent neuropsychological neurological examinations completed...
Purpose This study aimed to identify mental health, physical demographic and disease characteristics relating work productivity in people with multiple sclerosis (MS).Methods In this cross-sectional study, 236 employed MS (median age = 42 years, 78.8% female) underwent neurological neuropsychological assessments. Additionally, they completed questionnaires inquiring about (presenteeism: reduced while working, absenteeism: loss of due absence from work), characteristics. Multiple linear...
Abstract Background Neuropsychological symptoms in the Cognitive, Energetic, Behavioural, and Affective (CEBA) domains are common people with multiple sclerosis (PwMS) can negatively affect societal participation. The current study aims to investigate whether there combinations of different CEBA that consistently occur together, is, if profiles be identified. If so, this develop a screening instrument identifying PwMS select most suitable neuropsychological rehabilitation treatment for given...