A5013951435- Multiple Sclerosis Research Studies
- Dementia and Cognitive Impairment Research
- Systemic Sclerosis and Related Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Blood Pressure and Hypertension Studies
- Polyomavirus and related diseases
- Employment and Welfare Studies
- Peripheral Neuropathies and Disorders
- Powdery Mildew Fungal Diseases
- Neuroscience and Neuropharmacology Research
- Neurobiology of Language and Bilingualism
- Mobile and Web Applications
- Neurological Disorders and Treatments
- Advanced Differential Geometry Research
- Spatial Cognition and Navigation
- Health Promotion and Cardiovascular Prevention
- Effects of Vibration on Health
- Otitis Media and Relapsing Polychondritis
- Health, psychology, and well-being
- Genomic variations and chromosomal abnormalities
Leiden University
2015-2025
Elisabeth-TweeSteden Ziekenhuis
2015-2020
Multiple Sclerosis Foundation
2016
Leiden University Medical Center
2006-2011
Merus (Netherlands)
2003
Atrophy is regarded a sensitive marker of neurodegenerative pathology. In addition to confirming the well-known presence decreased global grey matter and hippocampal volumes in Alzheimer's disease, this study investigated whether deep structure also suffer degeneration such associated with cognitive deterioration. cross-sectional correlation study, two groups were compared on seven subcortical regions: 70 memory complainers (MCs) 69 subjects diagnosed probable disease. Using 3T 3D T1 MR...
Alzheimer's disease (AD) presents with significant neuropsychological deficits. Cognitive training in AD has recently started to demonstrate its efficacy. In this study, we implemented computerized cognitive of a large group early-stage patients, identify effects at level and investigate whether they were stable after 6 months.Overall, 80 patients randomized two groups. Patients the experimental used structured rehabilitative software three times week for 12 consecutive weeks aimed memory,...
Abstract Background Cognitive impairment occurs in up to 65% of people with multiple sclerosis (PwMS), negatively affecting daily functioning and health-related quality life. In general, neuropsychological testing is not part standard MS-care due insufficient time trained personnel. Consequently, a baseline assessment cognitive often lacking, hampering early identification decline change within person over time. To assess PwMS time-efficient manner, BICAMS-based self-explanatory digital...
Abstract Background Up to 65% of people with multiple sclerosis (PwMS) develop cognitive deficits, which hampers their ability work, participating in day-to-day life and ultimately reducing quality (QoL). Early symptoms are often less tangible PwMS direct environment noticed only when work functioning problems become more advanced, i.e., (brain) damage is already advanced. Treatment at a late stage can lead impairment unemployment, highlighting the need for preventative interventions PwMS....
This exploratory follow-up study investigated whether EEG parameters can predict future cognitive performance. Forty elderly subjects, ranging from cognitively unimpaired to those with Alzheimer disease underwent registration at baseline and neuropsychological examination both follow-up. We assessed relations between measures performance (i.e., global cognition, memory, language, executive functioning) controlling for age, time, Regression models were constructed on the Cambridge Cognitive...
Background: The cognitive and neuropsychiatric deficits present in patients with behavioral variant frontotemporal dementia (bvFTD) are associated loss of functionality the activities daily living (ADLs). main purpose this study was to examine explore association between features that might prompt functional impairment basic, instrumental, advanced ADL domains bvFTD. Methods: A retrospective cross-sectional conducted 27 bvFTD its early stage (<2 years evolution) 32 healthy control...
Self-reports of cognitive functioning are not always related to objective measures. We examined psychological characteristics patients with multiple sclerosis (MS) who underestimate, overestimate or accurately estimate their executive performance.The first phase was an inventory complaints by means self-reported (and partner-reported) questionnaires. At the second (January-October 2009), 114 128 participants met inclusion and exclusion criteria underwent neurological assessments.A total 19%...
Multiple Sclerosis (MS) is the most common cause of neurological disability in young and middle-aged adults. At this stage life people are midst their working career. The majority MS patients unable to retain employment within 10 years from disease onset. Leading up unemployment, many may experience a reduction hours or work responsibilities increased time missed work. MS@Work study examines various factors that influence participation relapsing-remitting patients, including disease-related...
Cognitive functioning has been linked to employment outcomes in multiple sclerosis (MS) cross-sectional studies. Longitudinal studies are however lacking and previous did not extensively examine executive functioning. We examined whether baseline cognitive predicts a change status after 2 years, while taking into account mood, fatigue disability level. A total of 124 patients with relapsing-remitting MS (pwMS) 60 healthy controls were included. They underwent neurological neuropsychological...
Background Up to 30% of recently diagnosed MS patients lose their jobs in the first four years after diagnosis. Taking into account personal and socio-economic importance sustaining employment, it is utmost examine factors involved with work participation. Objective To investigate differences self-reported functioning without a paid job. Methods Self-reports physical cognitive functioning, depression, anxiety fatigue were gathered from 44 relapsing-remitting within 3 years. Results Patients...
The heterogeneous nature of cognitive impairment in people with multiple sclerosis (PwMS) hampers understanding the underlying mechanisms and developing patient-tailored interventions. We aim to identify classify profiles PwMS, comparing these status (preserved versus impaired).
PurposeTo investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, work-related factors in people with multiple sclerosis (MS).Methods170 employed MS underwent yearly neurological neuropsychological examinations to assess MS-related disability cognitive functioning. Additionally, they completed questionnaires assessing depression, anxiety, fatigue, complaints, workplace support coping. Multilevel models for change were fitted examine...
The aim of this study was to examine whether work capabilities differ between workers with Multiple Sclerosis (MS) and from the general population. second investigate capability set related health outcomes. A total 163 MS MS@Work population were matched for gender, age, educational level working hours. All participants completed online questionnaires on demographics, functioning. Capability Set Work Questionnaire used explore a seven values is considered valuable (A), enabled in context (B),...
The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the during memory activation challenge showed abnormalities where resting did not. We investigated whether also reveals in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation underwent neurological, neuropsychological, MRI investigations. was registered rest condition, i.e. eyes closed, working task. each condition we determined absolute power theta (4-8 Hz) alpha (8-13 bands...
Evidence for the extent and nature of attentional impairment in premanifest manifest Huntington's disease (HD) is inconsistent. Understanding such impairments may help to better understand early functional changes HD could have consequences concerning care patients. We investigated control both HD. studied 17 subjects (mean age: 51 years), 12 43 15 healthy controls using sustained attention response task (SART), a simple Go/No-go test reflecting inhibitory processes through reaction time...
BackgroundCognitive deficits affect up to 70% of all patients with Multiple Sclerosis (MS) and have a significant impact on quality life. Cognitive assessments need be performed by neuropsychologist are often time-consuming, hampering timely identification adequate monitoring cognitive decline in MS.ObjectiveTo develop time-efficient, unsupervised, digital tool screen for MS.MethodsA (adjusted) version the Brief International Assessment MS, including Symbol Digit Modalities Test (SDMT,...
The majority of patients with Multiple Sclerosis (MS) are unable to retain employment within 10 years from disease onset. Executive abilities, such as planning, working memory, attention, problem solving, inhibition and mental flexibility may have a direct impact on the ability maintain job. This study investigated differences in subjective objective executive abilities between relapsing-remitting MS without paid We included 55 community-based sample (47 females; mean age: 47 years; 36%...
Symptoms of anxiety and depression affect the daily life people with multiple sclerosis (MS). This study examined work difficulties their relationship anxiety, coping style in MS.219 employed MS (median age = 43 years, 79% female) completed questionnaires on depression, style, demographics difficulties, underwent a neurological examination. Two regression analyses were performed as dependent variable either or continuous independent variables. Coping age, gender, educational level,...
Earlier research has found cross-sectional attentional control deficits in manifest Huntington's disease (HD) using neuropsychological testing combined with simultaneous P300 registration. In the current pilot-study, we investigate pre-manifest and HD over a 3-year follow-up period.Five (MHD), 9 (PMHD), 12 subjects were included. Sustained Attention to Response task (SART) registration resulted number of errors, reaction time (RT), amplitude latency. RT change patterns surrounding No-go...
Multiple sclerosis (MS) is a chronic disorder of the central nervous system with an unpredictable disease course. Life partners often become caregivers, which can be both rewarding and challenging, as caregiver's physical mental health negatively affected. Previous studies on caregiver strain focused caregivers persons MS relatively high disability levels, while may already experienced by life living mildly disabled MS.The current study examines factors associated in mild due to...
Job loss is common in multiple sclerosis (MS) and known to exert a negative effect on quality of life. The process leading up job typically includes work events, productivity losses need for accommodations. By using active coping strategies may be prevented or delayed.Our goal was examine events accommodations relation employed relapsing-remitting MS patients.Ninety-seven patients (77% females; 21-59 years old) completed questionnaires concerning the patient's situation, strategies,...