A5082048875- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Interpreting and Communication in Healthcare
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Hemispheric Asymmetry in Neuroscience
- Stroke Rehabilitation and Recovery
- Functional Brain Connectivity Studies
- Speech and dialogue systems
- Neurological disorders and treatments
- Action Observation and Synchronization
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Delphi Technique in Research
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Music Perception
- linguistics and terminology studies
- Developmental and Educational Neuropsychology
- Genetic Neurodegenerative Diseases
- Williams Syndrome Research
- Epilepsy research and treatment
- Language Development and Disorders
Pontificia Universidad Católica de Chile
2017-2024
Erasmus MC
2011-2024
University Medical Center Utrecht
2011-2017
To investigate arterial spin labeling (ASL)-MRI for the early diagnosis of and differentiation between two most common types presenile dementia: Alzheimer's disease (AD) frontotemporal dementia (FTD), distinguishing age-related from pathological perfusion changes. Thirteen AD 19 FTD patients, 25 age-matched older 22 younger controls underwent 3D pseudo-continuous ASL-MRI at 3 T. Gray matter (GM) volume cerebral blood flow (CBF), corrected partial effects, were quantified in entire...
Introduction Aphasia assessments in languages other than English are scarce. In the case of Spanish, this scarcity includes a need for with linguistic and cultural adaptations that consider dialectal varieties traits across Spanish-speaking populations.
For the development of minimally invasive brain-computer interfaces (BCIs), it is important to accurately localize area implantation. Using fMRI, we investigated which brain areas are involved in motor imagery. Twelve healthy subjects performed a execution and imagery task during separate fMRI EEG measurements. results showed that imagery, premotor parietal were most robustly activated individual subjects, but surprisingly, no activation was found primary cortex. spectral power decreases...
Background: The cognitive and neuropsychiatric deficits present in patients with behavioral variant frontotemporal dementia (bvFTD) are associated loss of functionality the activities daily living (ADLs). main purpose this study was to examine explore association between features that might prompt functional impairment basic, instrumental, advanced ADL domains bvFTD. Methods: A retrospective cross-sectional conducted 27 bvFTD its early stage (<2 years evolution) 32 healthy control...
Metabolic syndrome (MetS), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk several aging-related brain diseases, including Alzheimer's disease (AD). However, underlying mechanism explaining link between MetS function is poorly understood. Among possible mediators are adipose-derived secreted molecules called adipokines, adiponectin (ApN) resistin, which have been shown to regulate by modulating processes. To investigate...
<h3>BACKGROUND AND PURPOSE:</h3> Determining language dominance with fMRI is challenging in patients brain tumor, particularly cases of suspected atypical representation. Supratentorial activation patterns must be interpreted great care when the tumor or near presumed areas, where tissue mass effect can lead to false-negative results. In this study, we assessed cerebrocerebellar lateralization healthy participants and tumors a focus on <h3>MATERIALS METHODS:</h3> Twenty 38 underwent...
Background: There is an ongoing debate whether the effect of Melodic Intonation Therapy (MIT) in patients with severe non-fluent aphasia depends on recruitment right hemisphere (RH) structures for language functioning or re-recruitment left (LH) structures. So far, neuroimaging studies have produced conflicting evidence.Aims: To investigate a shift lateralisation occurs after intensive treatment subacute (<3 months post onset) and chronic (>1 year stroke aphasia.Method & Procedures: In...
Abstract Background Melodic Intonation Therapy ( MIT ) uses the melodic elements of speech to improve language production in severe nonfluent aphasia. A crucial element is melodically intoned auditory input: patient listens therapist singing a target utterance. Such input facilitates production, whereas spoken does not. Methods Using sparse sampling fMRI sequence, we examined differential processing and language. Nineteen right‐handed healthy volunteers performed an lexical decision task...
Aphasia research has traditionally been considered a (unidisciplinary) niche topic in medical science. The international Collaboration of Trialists (CATs) is global collaboration multidisciplinary aphasia researchers. Over the past 10 years, CATs collectively taken rigorous approach to systematically address persistent challenges quality. This article summarizes achievements over decade. CATs’ include: standardizing terminology, advancing design by expert consensus recommendations,...
Abstract Objetive . Decoding speech from brain activity can enable communication for individuals with disorders. Deep neural networks (DNNs) have shown great potential decoding applications. However, the limited availability of large datasets containing recordings speech-impaired subjects poses a challenge. Leveraging data healthy participants mitigate this limitation and expedite development neuroprostheses while minimizing need patient-specific training data. Approach In study, we...
Alzheimer's disease (AD) is characterized by a high etiological and clinical heterogeneity, which has obscured the diagnostic treatment efficacy, as well limited development of potential drugs. Sex differences are among risk factors that contribute to variability manifestation. Unlike men, women at greater developing AD suffer from higher cognitive deterioration, together with important changes in pathological features. Alterations glucose metabolism emerging key player pathogenesis AD,...
En el estudio de enfermedades neurodegenerativas, se ha considerado clásicamente a la enfermedad Alzheimer (EA) con una presentación típica síntomas cognitivos y cambios neuroanatómicos. No obstante, existen fenotipos clínicos EA cuyas bases neurobiológicas presentan similitud demencia frontotemporal (DFT). este sentido, heterogeneidad estos cuadros conlleva procesos evaluación diagnóstico poco certeros, debido al escaso conocimiento sobre sus neurocognitivos. El objetivo esta revisión...
Background We require high-quality information on the current burden, types of therapy and resources available, methods delivery, care pathways long-term outcomes for people with aphasia.Aim To document inform international delivery post-stroke aphasia treatment, to optimise recovery reintegration aphasia.Methods & Procedures Multi-centre, prospective, non-randomised, open study, employing blinded outcome assessment, where appropriate, including aphasia, able attend 30 minutes during initial...
Cognitive impairment is a typical sequel and solid long-term disability predictor that can be screened at early stages post-stroke. However, most routinely used cognitive screening tools were designed to detect dementia, which differs significantly from post-stroke impairment, including focal deficits. The Oxford Screen (OCS), bedside tool specifically for acute stroke, provides good alternative clinical practice. This study aims validating an American-Spanish version of the OCS (OCS-Sp) in...
Abstract Background The abbreviated version of the Token Test (aTT) is widely used to assess language comprehension deficits in stroke patients (SPs). However, aTT has not been validated for Latin American Spanish speakers, so clinicians tend use cut‐off scores developed countries. Aims To provide normative data (Sp‐aTT) healthy Chilean Spanish‐speaking and SP, determining influence sociodemographic variables such as gender, age education on Sp‐aTT performance. Methods & Procedures A...
Functional MRI (fMRI) is widely used to assess language lateralization, but its application in patients with brain tumors can be hindered by cognitive impairments, compensatory neuroplasticity, and artifacts due patient movement or severe aphasia. Gray matter volume (GMV) analysis via voxel-based morphometry (VBM) language-related regions may offer a stable complementary approach. This study investigates the relationship between GMV fMRI-derived lateralization healthy individuals...