A5079600775- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Alzheimer's disease research and treatments
- Inflammation biomarkers and pathways
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Vagus Nerve Stimulation Research
- Restraint-Related Deaths
- Psychological Treatments and Disorders
- Pediatric health and respiratory diseases
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Natural Compounds
- Mathematical and Theoretical Epidemiology and Ecology Models
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Adolescent and Pediatric Healthcare
- Neurogenetic and Muscular Disorders Research
- Immune Response and Inflammation
- Selenium in Biological Systems
- Stress Responses and Cortisol
- Neurological and metabolic disorders
- Infant Health and Development
Weizmann Institute of Science
2020-2024
University of Padua
2016-2019
Italian Institute of Technology
2019
University of Pavia
1991-1996
Infant
1991
Abstract Background For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over years, emerging studies highlighted involvement immune system neurodegenerative disease emergence severity. Numerous animal models amyloidosis demonstrated beneficial role monocyte-derived macrophages mitigating disease, though less is known regarding tauopathy. Boosting both tauopathy, resulted improved cognitive performance a reduction pathological...
Norbormide (NRB) is a unique compound that acts directly on rat vascular myocytes to trigger contractile process, through an as yet unknown mechanism, which results in the selective contraction of peripheral arteries. To gain insight into mechanisms involved NRB rat-selective activity, we investigated subcellular distribution NRB-AF12, nitrobenzodiazole (NBD)-derivative NRB, living NRB-sensitive and NRB-insensitive cells. In both cell types, NRB-AF12 localised endoplasmic reticulum (ER),...
Abstract The contributions of disease-associated microglia (DAM) and infiltrating monocyte-derived macrophages (MDM) to Alzheimer’s disease (AD) are still controversial. Here, using Trem2 −/− 5xFAD DAM-deficient mice, we addressed this issue by targeting the programmed cell death ligand-1 (PD-L1) immune checkpoint, shown modify AD via MDM recruitment. Treating mice resulted in cognitive improvement, rescue synapses, reduction soluble-amyloid beta (Aβ) 1−42 , with no effect on insoluble Aβ ....
Abstract Background The CNS constantly monitors the organism’s internal state and orchestrates adaptive responses to perturbation of body’s homeostasis. Emerging evidence revealed that brain can also instruct immune responses, which in turn affect condition other organs, including itself. Method We used neuronal retrograde‐labelling, flow‐cytometry, mass cytometry, scRNAseq cognitive tests animal model Alzheimer’s disease (5xFAD) study relevance Brain‐Immune axis context Disease. Results...
The relative contributions of microglia and infiltrating monocyte-derived macrophages (MDMs) to containing Alzheimer's disease (AD) are not fully understood. In the 5xFAD animal model amyloidosis, disease-associated (DAM) expressing Triggering receptor expressed on myeloid cells 2 (TREM2), found in close proximity amyloid beta (Aβ) plaques. Deletion TREM2 results absence DAM an increased Aβ-plaque load. However, necessity for resolving AD pathology is still debatable.Here, we activated...
Compelling evidence attributes a key role to the immune system in Alzheimer's disease (AD) pathogenesis. Considering influence of female reproductive life history on inflammatory activity, we studied impact pregnancy course women carrying APP or PSEN1 mutation, two most relevant genes involved early-onset familial disease.