A5077146765- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Multiple and Secondary Primary Cancers
- Intraperitoneal and Appendiceal Malignancies
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Genital Health and Disease
- Appendicitis Diagnosis and Management
- COVID-19 and healthcare impacts
- Surgical site infection prevention
- Gynecological conditions and treatments
- Sarcoma Diagnosis and Treatment
- Maternal and fetal healthcare
- Ion channel regulation and function
- Urinary and Genital Oncology Studies
- Diagnosis and treatment of tuberculosis
- Acne and Rosacea Treatments and Effects
- Cancer, Lipids, and Metabolism
- Receptor Mechanisms and Signaling
- Pregnancy-related medical research
- Soft tissue tumor case studies
- Liver Disease Diagnosis and Treatment
Sivas State Hospital
2024
Memorial Ankara Hospital
2021-2023
Ankara Mevki Asker Hastanesi
2020-2022
Sağlık Bilimleri Üniversitesi
2018-2021
Women’s Health Care
2014-2020
University of Health Sciences
2019-2020
Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi
2014-2019
University of Health Science
2019
Gynecologic Oncology Group
2016-2019
Ministry of Health
2019
The rewarding properties of the psychoactive constituents marijuana, termed “cannabinoids,” may reflect actions on synaptic transmission in nucleus accumbens (NAc). Furthermore, long-term changes these synapses support addictive process. Excitatory and inhibitory are acutely inhibited by cannabinoids NAc, endogenous (endocannabinoids) play a critical role expression depression (LTD) excitatory cortical afferents this structure. Because humans often use marijuana for prolonged periods, we...
Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), with cannabinoid receptors in hippocampus. Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for learning memory, consequences prolonged exposure to Delta(9)-THC function are poorly understood. Rats were injected (10 mg/kg, i.p., q.d.) 1, 3, or 7 d, electrophysiological...
Objective:The aim of this study was to determine the prognostic value lymph node ratio (LNR) in women with 2018 International Federation Gynecology and Obstetrics stage IIIC cervical cancer.Methods: In retrospective dual-institutional study, a total 185 node-positive cancer patients who had undergone radical hysterectomy systematic pelvic paraaortic lymphadenectomy were included.All received adjuvant chemoradiation after surgery.LNR defined as positive nodes (LNs) number LNs removed.The...
A novel, non-CB1 cannabinoid receptor has been defined by the persistence of inhibition glutamatergic EPSPs agonist WIN55,212-2 in mice lacking cloned CB1 (CB1-/-) (Hajos et al., 2001). This novel was also distinguished from its sensitivity to antagonist SR141716A and insensitivity AM251 & Freund, 2002). We have chosen refer this putative as CBsc due identification on Schaffer collateral axon terminals hippocampus. examined properties receptors Sprague Dawley (SD) rats two strains wild-type...
The objective of this study was to assess the predictive role neutrophil/lymphocyte ratio (NLR) for invasion gestational trophoblastic disease (GTD).A retrospective analysis conducted on 127 women who were managed at our clinic GTD. Of all patients, 8 showed according histological examination. clinical parameters patients with invasive GTD (Group 1; n=8) compared no 2; n=119). All underwent a prior uterine evacuation and followed up by regular assessment β-hCG titers.Demographic obstetric...
A human recombinant L-type Ca<sup>2+</sup> channel (α<sub>1C,77</sub>) was coexpressed with the rat angiotensin AT<sub>1A</sub> receptor in <i>Xenopus laevis</i> oocytes. In oocytes expressing only α<sub>1C,77</sub> channels, application of II (1–10 μm) did not affect amplitude or kinetics Ba<sup>2+</sup> currents (I<sub>Ba</sub>). sharp contrast, coexpressing α<sub>1C,77</sub>channels and receptors, 1 nm to μm gradually reversibly inhibited I<sub>Ba</sub>, without significantly changing its...
Objective: The aim of this study was to determine the value amniotic fluid interleukin-6 (IL-6) and C-reactive protein (CRP) levels in prediction preterm delivery singleton pregnancies without any known risk factors for Turkish women. Materials Methods: Patients present perinatology department who underwent mid-trimester genetic amniocentesis due evidence increased aneuploidy their prenatal serum screening tests were included study. A sample from each patient assessed IL-6 CRP....
The aim of this study was to evaluate the relationship between placental localisation and perinatal outcomes. This performed in a tertiary centre hospital by retrospectively analysing medical records patients who were followed up underwent delivery same hospital. divided into two groups according locations (central lateral) their routine sonographic findings 18 24 weeks' gestation. Out 1,057 patients, 87.4% (n = 919) had centrally located placentas 12.6% 133) laterally placentas....
The purpose of this case-control study was to compare the prognoses women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplatin chemotherapy those serous epithelial cancer (EOC) treated in similar manner. We performed a multicenter, retrospective review identify patients MOC at seven gynecologic oncology departments Turkey. Eighty-one were included. Each case matched two EOC terms age, tumor grade, substage...
To compare the effectiveness of topical lidocaine spray compared to a placebo for relieving pain during colposcopic cervical biopsies and endocervical curettage.This randomized, placebo-controlled, double-blind study included patients with abnormal cytologic results requiring colposcopy directed punch biopsy or without curettage (ECC). The were randomly assigned either 10% group. asked rate level immediately after ECC, mean scores 2 groups compared.A total 214 women in study: 104 group 110...
Background: To evaluate the clinical significance of atypical squamous cells undetermined (ASCUS) in PAP test post-menopausal women and compare with reproductive age women. Materials Methods: A total 367 patients who referred to our gynecologic oncology clinic were included study between September 2012 August 2013. Data for 164 (group 1) 203 pre-menopausal 2) ASCUS cytology evaluated retrospectively. Immediate colposcopy endocervical curettage was performed both groups conization all a...
To determine the optimal cone size to achieve a reliable sensitivity and specificity for clear surgical margins after cold knife conization (CKC).The medical reports of patients who had high-grade cervical intraepithelial lesions, carcinoma in situ, or stage 1A1 microinvasive their CKC specimens between June 2008 January 2015 were reviewed retrospectively.In total, 315 women fulfilled inclusion criteria. The mean age was 40.7 years. results squamous lesion (HSIL) 8 307 patients,...
Hydronephrosis is frequently encountered in advanced stage cervical cancers, and may be associated with mortality. In the present study, we aimed to demonstrate effect of hydronephrosis on survival patients inoperable cancer.The study data were acquired by retrospective analysis patient records belonging 165 women FIGO (International Federation Gynecology Obstetrics) stage-IIIB or more cancer, which not surgical candidates. Parameters including age, pathological diagnosis, disease stage,...
The purpose of this study was to investigate the prognostic value lymph node ratio (LNR) in women with stage IIIC endometrioid endometrial cancer (EC).A multicenter, retrospective department database review performed identify patients pure EC at 6 gynecologic oncology centers Turkey. A total 207 were included. LNR, defined as percentage positive nodes (LNs) recovered, stratified into 2 groups: LNR1 (≤0.15), and LNR2 (>0.15). Kaplan-Meier method used generate survival data. Factors predictive...
To assess the usefulness of adding PET/CT as a preoperative test for determining extent endometrial cancer and discriminating low- high-risk patients to identify candidates surgical staging.We retrospectively reviewed 86 with pathologically proven who had undergone ¹⁸F-FDG PET/CT. The prognostic relationships between parameters pathology reports were assessed.The SUVmax was significantly higher in FIGO stage IB or compared those IA; III-IV I-II; lymph node metastasis without metastasis....
Na+-Ca2+ exchanger is one of the major sarcolemmal Ca2+ transporters cardiac myocytes. In frog ventricular myocytes regulated by isoproterenol via a beta-adrenoreceptor/adenylate-cyclase/cAMPdependent signaling pathway providing molecular mechanism for relaxant effect hormone. Here, we report on presence novel exon 27-base pair insertion, which generates nucleotide binding motif (P-loop) in exchanger. To examine functional role this motif, constructed full-length heart cDNA (fNCX1a)...
This study investigates the protective effect of N-stearoylethanolamine (NSE), a bioactive N-acylethanolamine , on lipid profile distribution in pancreas obesity-induced insulin resistant (IR) rats fed with prolonged high fat diet (58% for 6 months). The phospholipid composition was determined using 2D thin-layer chromatography. level individual phospholipids estimated by measuring inorganic phosphorus content. fatty acid (FA) and cholesterol were investigated gas-liquid Compared to...
Background/aim: The purpose of this study is to investigate the prognostic significance lower uterine segment (LUS) involvement in endometrial cancer (EC). Materials and methods: We reviewed patients who were operated at our institution between July 2007 March 2015 with diagnosis EC. Tumors localized corpus involving LUS or entirely formed Group A, while tumors without B. Clinicopathological characteristics survival compared both groups. Results: A total 500 included study. There 139 had 361...
<b><i>Background:</i></b> The study aims to determine the detrimental effects of 7.5 mg/kg/day isotretinoin treatment on anti-Mullerian hormone (AMH) levels in an experimental see whether ovarian reserve are reversible. <b><i>Methods:</i></b> Blood was sampled 16 Sprague-Dawley albinos before any baseline AMH levels. Then, rats were randomly divided into 2 groups. Control group received only 1.0 ml soybean oil per oral for 30 days, whereas...