Aytekin Tokmak

ORCID: 0000-0001-5739-5689
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About
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Research Areas
  • Ovarian function and disorders
  • Pregnancy and preeclampsia studies
  • Reproductive System and Pregnancy
  • Endometriosis Research and Treatment
  • Reproductive Biology and Fertility
  • Ovarian cancer diagnosis and treatment
  • Assisted Reproductive Technology and Twin Pregnancy
  • Uterine Myomas and Treatments
  • Birth, Development, and Health
  • Gynecological conditions and treatments
  • Pregnancy and Medication Impact
  • Ectopic Pregnancy Diagnosis and Management
  • Endometrial and Cervical Cancer Treatments
  • Maternal and fetal healthcare
  • Sperm and Testicular Function
  • Gestational Diabetes Research and Management
  • Congenital Diaphragmatic Hernia Studies
  • Maternal and Perinatal Health Interventions
  • Pregnancy-related medical research
  • Neonatal Respiratory Health Research
  • Urological Disorders and Treatments
  • Intestinal and Peritoneal Adhesions
  • Hernia repair and management
  • Hormonal and reproductive studies
  • Sexual Differentiation and Disorders

Kırıkkale University
2024

Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi
2009-2023

Women’s Health Care
2010-2023

University of Health Science
2021-2023

Sağlık Bilimleri Üniversitesi
2017-2023

Weatherford College
2023

Bilkent University
2022-2023

University of Health Sciences
2022

Ankara Bilkent City Hospital
2022

University of Health Sciences Antigua
2022

Objectives: Phthalates and bisphenol-A (BPA) may pose a risk for human reproduction. Adverse effects of endocrine disturbing chemicals on animal ovaries have been proposed previously. This study was designed to measure the concentrations phthalate diesters or their metabolites in serum evaluate relevance with primary ovarian insufficiency (POI).Methods: as cross sectional case-control study. The group consisted 30 women diagnosed POI whereas healthy fertile without any systemic diseases were...

10.1080/09513590.2018.1534951 article EN Gynecological Endocrinology 2019-01-13

The aim of this study was to evaluate pregnancy outcomes in women with Ankylosing Spondylitis (AS), and the course disease during also assessed.This case-control included 60 pregnant who delivered our clinic between March 2007 2015. Twenty them diagnosed AS formed group 40 were chosen as control group. These patients reviewed by their hospital records evaluated retrospectively terms clinical characteristics, complications perinatal outcomes. Disease Activity Score (ASDAS), a new composite...

10.3109/14767058.2015.1089432 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2015-09-28

The aim of this study was to evaluate serum levels inducible nitric oxide synthase (INOS), myeloperoxidase (MPO), total antioxidant status (TAS), and oxidative (TOS) in women with primary ovarian insufficiency (POI) compare them healthy fertile women. We also examined the possible risk factors associated POI.This cross-sectional case control conducted Zekai Tahir Burak Women's Health Education Research Hospital. population consisted 44 POI (study group) 36 (control group). In all patients,...

10.1590/so100-720320150005397 article EN DOAJ (DOAJ: Directory of Open Access Journals) 2015-09-01

This study assessed the risk factors for poor clinical outcomes in patients with tubo-ovarian abscess (TOA). Patients managed medical therapy and discharged within 7 days without complications constituted favourable prognosis group (n = 22), whereas those who were surgically or after of antibiotic 87). Variables including age, gravidity, number dilation curettage procedures, caesarean delivery, smoking status, serum C-reactive protein levels, white blood count, body temperature, diameter,...

10.3109/01443615.2014.991294 article EN Journal of Obstetrics and Gynaecology 2014-12-29

Relationships between poor prognosis of ovarian malignancies and changes in complete blood count parameters have been proposed previously. In this work, we aimed to evaluate clinicopathologic features adolescents with adnexal masses sought establish any predictive value the platelet lymphocyte ratio (PLR) diagnosis.This retrospective study was conducted on 196 adolescent females masses. Three groups were constituted respect clinical or histopathology results: group 1, non-neoplastic patients...

10.7314/apjcp.2015.16.5.2037 article EN cc-by Asian Pacific Journal of Cancer Prevention 2015-03-18

Striae gravidarum (SG), commonly called stretch marks, is an important cosmetic problem which not treatable, although preventive measures might be effective. The aim of this study was to determine individual risk factors causing SG and the degree could effective.This prospective observational included 211 singleton primiparous pregnant women who were hospitalized for birth did have systemic diseases or other factors, like drug use polyhydramnios. Patients examined divided into two groups...

10.1016/j.jcma.2015.12.007 article EN cc-by-nc-nd Journal of the Chinese Medical Association 2016-04-05

To assess thiol/disulphide homeostasis and lipid accumulation product index, to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents polycystic ovary syndrome (PCOS).Case-control study.Education Research Hospital.Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, 3: 27 4: 96 age-matched, weight healthy controls.Serum profiles, hormonal parameters were measured. Lipid index (LAP index) model assessment (HOMA-IR)...

10.1111/cen.12965 article EN Clinical Endocrinology 2015-10-23

Prediction of preeclampsia and adverse maternal perinatal outcomes with biomarkers has been proposed previously. Anti-mullerian hormone (AMH) is a growth factor, which primarily responsible the regression mullerian duct, but also used to predict ovarian reserve decreases age similar fertility.To evaluate predictive role anti-mullerian (mAMH) in preeclampsia.This prospective case-control study was conducted at current high-risk pregnancy department tertiary research hospital 45 cases...

10.3109/14767058.2014.955007 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2014-08-18

This study aimed to investigate the influence of obesity on pregnancy complications and neonatal outcomes in diabetic nondiabetic women.This retrospective case control was conducted 1193 pregnant women their neonates at a tertiary level maternity hospital between March 2007 2011. The were classified into 2 groups according presence diabetes mellitus. Six hundred seven patients with gestational or pregestational formed group (study group) 586 (control group). Demographic characteristics, body...

10.1055/a-0589-2833 article EN cc-by Geburtshilfe und Frauenheilkunde 2018-04-01

The aim of this study was to evaluate predictive role risk malignancy index in discriminating between benign and malignant adnexal masses preoperatively.This retrospective conducted with a total 569 patients masses/ovarian cysts managed surgically at our clinic January 2006 2012. Obtained data from patient files were age, gravidity, parity, menopause status, ultrasound findings CA125 levels. For all scans performed. the assessment (RMI) Jacobs' model used. Histopathologic results recorded...

10.7314/apjcp.2014.15.18.7793 article EN cc-by Asian Pacific Journal of Cancer Prevention 2014-10-11

The present study was designed to evaluate the association between anti-Mullerian hormone (AMH) and insulin resistance (IR) in non-obese adolescent females with polycystic ovary syndrome (PCOS) without IR.Seventy-seven consecutive patients were recruited distributed into three groups according diagnoses of PCOS IR. Group I included 27 diagnosed IR, group II 18 but III 32 controls PCOS.Group had significantly higher AMH levels compared (p < 0.012 p 0.000, respectively). ROC curve analyses...

10.1080/09513590.2016.1193140 article EN Gynecological Endocrinology 2016-06-08

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women reproductive age. The etiopathogenesis disease remains uncertain. Additionally, a full consensus has not been reached regarding PCOS diagnostic criteria. Several attempts have made to diagnose with simple clinical biomarker, but them failed. This study aims investigate possible association between and anogenital distance (AGD), which an important sign intrauterine androgen exposure.A prospective cohort...

10.1097/jcma.0000000000000150 article EN cc-by-nc-nd Journal of the Chinese Medical Association 2019-07-29

The aim of our study was to evaluate serum high-sensitivity C-Reactive Protein (hs-CRP), sialic acid (SA), and interleukin-6 (IL-6) levels in pregnancies complicated with preeclampsia (PE) intrauterine growth restriction (IUGR) compare healthy pregnancies. This conducted at a tertiary-level maternity hospital 80 pregnant women. Fasting blood samples were taken from 44 consecutive women by PE (n: 20) IUGR 24), 36 normal Serum hs-CRP, SA, IL-6 concentrations measured all participants. mean...

10.1684/ecn.2019.0423 article EN European Cytokine Network 2019-03-01

This study aimed to evaluate the association between complications and clinical parameters with obesity in 273 women who have undergone abdominal myomectomy during period.The patients were classified into two groups according body mass index (BMI) (≤30 kg/m(2) >30 kg/m(2)). Demographic, preoperative postoperative evaluated.Demographic, evaluated. The results showed statistically significant differences obese non-obese terms of age, gravidity, diameter fibroid (DOF), hemoglobin, duration...

10.1016/j.jcma.2016.02.008 article EN cc-by-nc-nd Journal of the Chinese Medical Association 2016-05-25

Abstract Background We aimed to determine whether adding metformin carboplatin treatment would reduce the damage ovarian reserve associated with use. Methods included 35 adult female non-pregnant albino Wistar rats approximately three months old, weighing 220–310 g. The were divided into five groups of seven according they received. Carboplatin and salin was given Group 2, plus 3. 4 administered only metformin. 5 salin. Groups 2 3 as a single dose on 15th day, while during 28-day experiment....

10.1186/s13048-023-01259-2 article EN cc-by Journal of Ovarian Research 2023-09-02

Objective: To study whether there is any relationship between a serum tumor markers panel (CA19-9, CA 125, CEA, CA15-3 and AFP) the size in patients with ovarian dermoid cyst reproductive age.Background: Between January 2006-2007, 160 were operated Department of Infertility, Zekai Tahir Burak Women Health Hospital due to cyst.Methods: The clinical data levels retrieved from records department.This was retrospective study.Results: Forty-four (37.6 %) had high 19-9 , twenty-seven (19.3 125...

10.4149/bll_2012_022 article EN Bratislavské lekárske listy/Bratislava medical journal 2012-01-01

Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology physiopathology. The aim this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 ADAMTS18 levels between pre-eclampsia control groups investigate role these pre-eclampsia.Forty-one women diagnosed as 30 40 weeks gestation 41 non-complicated pregnant were enrolled cross-sectional, case-control prospective study. ELISA method used...

10.3109/14767058.2015.1087497 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2015-09-18

Objective: This study investigated the discriminative values of neutrophil-to-lymphocyte ratio (NLR), serum amyloid A protein (SAA), and C-reactive (CRP) in cases primary ovarian insufficiency (POI). Methods: total 84 women were included this comparative cross-sectional study. The group consisted 43 diagnosed as having POI, control 41 with normal fertility. After obtaining a written informed consent form from all participants, we retrieved clinical demographic data laboratory findings...

10.1097/gme.0000000000000423 article EN Menopause The Journal of The North American Menopause Society 2015-02-03

Background: To evaluate the clinical significance of atypical squamous cells undetermined (ASCUS) in PAP test post-menopausal women and compare with reproductive age women. Materials Methods: A total 367 patients who referred to our gynecologic oncology clinic were included study between September 2012 August 2013. Data for 164 (group 1) 203 pre-menopausal 2) ASCUS cytology evaluated retrospectively. Immediate colposcopy endocervical curettage was performed both groups conization all a...

10.7314/apjcp.2014.15.16.6639 article EN cc-by Asian Pacific Journal of Cancer Prevention 2014-08-30
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