A5068724475- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Virus-based gene therapy research
- Air Quality and Health Impacts
- Immune cells in cancer
- Occupational and environmental lung diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Glutathione Transferases and Polymorphisms
- Circular RNAs in diseases
- Occupational Health and Performance
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Response and Inflammation
- Nitrogen and Sulfur Effects on Brassica
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Antioxidant Activity and Oxidative Stress
- Nanoplatforms for cancer theranostics
- Advancements in Transdermal Drug Delivery
Houston Methodist
2020-2024
Fudan University
2024
Huashan Hospital
2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
Shanghai Clinical Research Center
2024
Weill Cornell Medicine
2022
Cornell University
2022
Weihai Municipal Hospital
2022
Shandong University
2022
People's Liberation Army 401 Hospital
2017
A phase 1/2 clinical trial in patients with chemoresistant triple-negative breast cancer targets the inducible nitric oxide signaling pathway.
Immunosuppressive elements within the tumor microenvironment, such as tumor-associated macrophages (TAM), can present a barrier to successful antitumor responses by cytolytic T cells. Here we employed preclinical syngeneic p53 null mouse models of triple-negative breast cancer (TNBC) develop treatment regimen that harnessed immunostimulatory effects low-dose cyclophosphamide coupled with pharmacologic inhibition TAMs using either small-molecule CSF1R inhibitor or an anti-CSF1R antibody. This...
Abstract The expression dysregulation of microRNAs (miRNA) has been widely reported during cancer development, however, the underling mechanism remains largely unanswered. In present work, we performed a systematic integrative study for genome-wide DNA methylation, copy number variation and miRNA data to identify mechanisms underlying in lower grade glioma. We 719 miRNAs whose was associated with alterations or promoter methylation. Integrative multi-omics analysis revealed four subtypes...
Abstract Purpose: A Phase 2 trial of stereotactic radiotherapy and in situ cytotoxic virus therapy patients with metastatic triple-negative breast cancer (mTNBC) followed by pembrolizumab (STOMP) was designed to evaluate dual approach enhancing single-agent immune checkpoint blockade adenovirus-mediated expression herpes-simplex-virus thymidine-kinase (ADV/HSV-tk) plus valacyclovir gene body (SBRT) mTNBC. Patients Methods: In this single-arm, open-label trial, mTNBC were treated ADV/HSV-tk...
Brain metastasis is the most devasting form of lung cancer. Recent studies highlight significant differences in tumor microenvironment (TME) between cancer brain (LCBM) and primary cancer, which contribute significantly to progression drug resistance. Cancer-associated fibroblasts (CAFs) are major component pro-tumor TME with high plasticity. However, lineage composition function CAFs LCBM remain elusive. By reanalyzing single-cell RNA sequencing (scRNA-seq) data (GSE131907) from patients...
microRNAs play key roles during various crucial cell processes such as proliferation, migration, invasion and apoptosis. Also, have been shown to possess oncogenic tumor-suppressive functions in human cancers. Here, we describe the regulation function of miR-149 colorectal cancer lines. expression patterns were detected lines tissue samples, then focused on its role growth, invasion, target gene identification. Furthermore, was analyzed vitro vivo. downregulated HCT116 SW620 compared normal...
An effective therapeutic cancer vaccine should be empowered with the capacity to overcome immunosuppressive tumor microenvironment. Here, authors describe a mRNA virus-mimicking platform that is comprised of phospholipid bilayer encapsulated protein-nucleotide core consisting antigen-encoding molecules, unmethylated CpG oligonucleotides and positively charged proteins. In cell culture, VLVP potently stimulated bone marrow-derived dendritic cells (BMDCs) express inflammatory cytokines...
Tuberculosis is a leading cause of death in mankind due to infectious agents, and Mycobacterium tuberculosis (Mtb) infects survives macrophages (MФs). Although MФs are major niche, myeloid-derived suppressor cells (MDSCs) an alternative site for pathogen persistence. Both MDSCs express varying levels leukocyte immunoglobulin-like receptor B (LILRB), which regulate the myeloid cell suppressive function. Herein, we demonstrate that antagonism LILRB2 by monoclonal antibody (mab) induced switch...
Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to checkpoint blockade, when compared those minimal T-cell infiltration (cold tumors). We report here that patients lung cancer different racial backgrounds harbored distinct cell profiles in the tumor microenvironment. Compared African Americans (AA), Caucasian (CA) exhibited increased and vasculature, survival. Changes of survival profile were most pronounced among active smokers nonsmokers, former...
Compound Arnebiae radix oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable inconvenient use. The aim of this study was prepare compound microemulsion gel transdermal delivery system evaluate its characteristics.Based on the solubility Shikonin, active component results phase studies, adequate ratio each in determined. optimized prepared using Carbomer 940. gels were characterized terms appearance, preliminary stability test content Shikonin...
1079 Background: Pembrolizumab, stereotactic body radiotherapy (SBRT), and viral vector-based gene therapy such as adenovirus-mediated expression of herpes simplex virus thymidine kinase (ADV/HSV-tk) plus ganciclovir have each shown antitumor immune activity. The combination those modalities may represent a window opportunity to enhance pembrolizumab efficacy in mTNBC patients. Methods: In this single-arm, open-label phase II trial, patients were treated with situ oncolytic ADV/HSV-tk (5 x...
Background: Lower grade glioma (LGG) is the most frequent primary tumors of central nervous system and has been a major healthcare burden, however, specific molecular mechanism underlying its initiation progression remains to be elucidated.Methods: In present work, we performed systematic integrative study for DNA methylation, copy number variation miRNA expression data identify mechanisms dysregulation subtyping LGG. The relationship between LGG subtypes features, tumor immune...
Abstract Background Lower grade glioma (LGG) is the most frequent primary tumors of central nervous system and has been a major healthcare burden, however, specific molecular mechanism underlying its initiation progression remains to be elucidated. Although it known that microRNAs (miRNAs) are widely involved in regulation malignant phenotypes glioma, underling for miRNA dysregulation largely unanswered. Methods In present work, we developed novel strategy obtain genome wide copy number...
Abstract Background: With the recent advancement in perioperative treatment protocols, search for clinical biomarkers that can predict overall response and long-term cancer outcome independent from acquires even more importance. Recently, it has become clear mechanical properties of tumor microenvironment solid tumors play a key role driving outcome, mediating immune infiltration activation, to therapy. Moreover, growing body evidence supports understanding changes induced by plethora...
Abstract Background: With the recent advancements of spatial omics, it has become increasingly recognized that analysis tumor architecture is key to decipher heterogenous intratumoral relationships between different components and provide better understanding cancer therapy resistance, as well help identify potential targets for personalized therapy. The challenge discovery implementation such biomarkers still lays in technological methodological difficulties, their translation into clinical...
<div><p>Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to checkpoint blockade, when compared those minimal T-cell infiltration (cold tumors). We report here that patients lung cancer different racial backgrounds harbored distinct cell profiles in the tumor microenvironment. Compared African Americans (AA), Caucasian (CA) exhibited increased and vasculature, survival. Changes of survival profile were most pronounced among active smokers...
Abstract The sympathetic nervous system (SNS) is an important regulator of immune cell function during homeostasis and states inflammation. Recently, the SNS has been found to bolster tumor growth impair development antitumor immunity. However, it unclear whether can modulate APC function. Here, we investigated effects signaling in murine monocyte-derived macrophages (moMФ) dendritic cells (DCs) further combined nonspecific β-blocker propranolol with a peptide cancer vaccine for treatment...
During the 9/11 attacks, individuals were exposed to World Trade Center (WTC) dust which contained a complex mixture of carcinogens. Epidemiologic studies have revealed increased incidence prostate and thyroid cancer in WTC survivors responders. While reports shown that WTC-dust associates with prevalence inflammatory-related disorders, date not determined whether this exposure impacts progression. In study, we used genetically engineered mouse (GEM) models prostate-specific deletion PTEN...
Objective. Heparin-binding protein (HBP) plays an important role in sepsis and is a prognostic biomarker patients with sepsis, but the of HBP pathogenesis sepsis-associated acute lung injury (ALI) remains unclear. This study aimed to investigate sepsis-induced ALI its underlying molecular mechanisms. Methods. The cecal ligation puncture (CLP) model was used induce mice randomly divided into 4 groups: control group, CLP (rats treated puncture), injection), + UFH injection unfractionated...
Abstract Immunosuppressive elements within the tumor microenvironment such as Tumor Associated Macrophages (TAMs) can present a barrier to successful anti-tumor responses by cytolytic T cells. We employed preclinical syngeneic p53 null mouse models of triple negative breast cancer (TNBC) develop treatment regimen that harnessed immunostimulatory effects low-dose cyclophosphamide coupled with pharmacologic inhibition TAMs using either small molecule CSF1R inhibitor or an anti-CSF1R antibody....
To develop a kit of time-resolved fluoroimmunoassay (TRFIA) for detection Schistosoma japonicum protein SjP38, and evaluate its effectiveness.The anti 9G7 SjP38 monoclonal antibody was used as the capture anti-body coated with 96-hole plate, Eu3+ labeled 1A6 to establish TRFIA kit. In addition, accuracy, sensitivity, precision, stability coincidence rate pathogenic diagnosis were evaluated.This established possessed high wide linear range from 2 1 250 ng/ml, sensitivity minimum detectable...
Abstract Background: Understanding breast cancer progression and the relationships among biomarkers in tumor microenvironment could go beyond established prognostic markers of cancer. Poor response recurrence may indeed be a consequence highly heterogeneous spatial distribution within cancers, and/or synergistic antagonistic relationship between co-localized biomarkers. Recently, mechanical physical microenvironmental signatures have emerged as relevant determining aggressiveness...
<div>Abstract<p>Immunosuppressive elements within the tumor microenvironment, such as tumor-associated macrophages (TAM), can present a barrier to successful antitumor responses by cytolytic T cells. Here we employed preclinical syngeneic p53 null mouse models of triple-negative breast cancer (TNBC) develop treatment regimen that harnessed immunostimulatory effects low-dose cyclophosphamide coupled with pharmacologic inhibition TAMs using either small-molecule CSF1R inhibitor or...
Supplementary Data from Chemotherapy Coupled to Macrophage Inhibition Induces T-cell and B-cell Infiltration Durable Regression in Triple-Negative Breast Cancer