A5000748486- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Uterine Myomas and Treatments
- Colorectal and Anal Carcinomas
- Cutaneous Melanoma Detection and Management
- Reproductive System and Pregnancy
- Genital Health and Disease
- Urinary and Genital Oncology Studies
- Corneal surgery and disorders
- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Urologic and reproductive health conditions
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Light effects on plants
- Ultrasound in Clinical Applications
- Structural Engineering and Vibration Analysis
- Cancer Mechanisms and Therapy
- Helicobacter pylori-related gastroenterology studies
- Natural Language Processing Techniques
Brigham and Women's Hospital
2000-2023
Harvard University
1997-2023
Orlando Health
2019-2023
Westmead Hospital
2021-2022
Melanoma Institute Australia
2020
Royal Prince Alfred Hospital
2020
Ministry of Health
2020
Mount Sinai Medical Center
2019
University of Southern Denmark
2018
Odense University Hospital
2018
Mucinous ovarian neoplasms other than cystadenomas and adenofibromas have been classified as either borderline tumors or carcinomas for many years. Borderline subdivided more recently into endocervical-like (mullerian) intestinal forms. Such a distinction is rarely made in the mucinous carcinoma category. We did not encounter pure present series. Criteria distinguishing an intestinal-type tumor from controversial. In this study of 164 type 32 carcinomas, former were further 74 cases with...
The gross and routine microscopic features of 25 stage I primary mucinous ovarian carcinomas without clinical evidence recurrence metastatic to the ovaries were compared. Findings that frequent in latter strongly favored a metastasis were: 1) bilaterality, 2) surface involvement by epithelial cells (surface implants), 3) an infiltrative pattern stromal invasion. less but present exclusively or almost nodular invasive pattern, hilar involvement, single cell invasion, 4) signet-ring cells, 5)...
We investigated the possibility of distinguishing between primary endometrial and endocervical adenocarcinomas by using a panel immunohistochemical stains, which included vimentin (VIM), carcinoembryonic antigen (CEA), epithelial membrane (EMA), cytokeratins 7 20 (CK7 CK20). Twenty-nine (CCAs) 30 (EMCAs) including cases with overlapping histologic features (CCAs endometrioid differentiation [15/29] EMCAs mucinous [16/30]) were evaluated. Most (29/30, 97%) VIM positive, whereas only 2/29 (7%)...
Five panelists independently reviewed 135 consecutive conventional cervical smears (CPs) originally classified as atypical glandular cells of undetermined significance (AGUS). A thin-layer slide (TP), prepared from the residual material, also was in each case. All patients underwent colposcopy that yielded at least 1 histologic specimen. Three or more 5 reviewers retained AGUS interpretation for 29% CPs and 12% corresponding TPs. Interobserver variability infrequency use marked,...
To evaluate the cytologic features of each subtype renal cell carcinoma (RCC) for separating various subtypes.Thirty-eight fine needle aspiration (FNA) specimens with surgical resection follow-up were retrospectively reviewed and classified without knowledge specimen diagnosis. These included 18 clear RCCs, 8 papillary 4 oncocytomas, 2 chromophobe sarcomatoid RCCs metastases to kidney.Seventy-four percent primary lesions correctly classified. All oncocytomas tumors classified, while both 3...
Abstract Atypical cells thought to be of endocervical glandular origin often cause diagnostic uncertainty in cervicovaginal smears. For this reason consecutive cases atypia diagnosed smears were correlated with subsequent biopsy diagnoses and then retrospectively reviewed. Smears originally as “mild atypia, probably reactive” or “severe suggestive adenocarcinoma situ” (AIS). Biopsy follow‐up was obtained on 34 58 patients severe atypia. Nine (26%) had AIS, three concomitant high‐grade...
Adenocarcinoma of the cervix is increasing in frequency. There a dearth specific detail concerning histomorphology, histogenesis, and associated findings early invasive cervical adenocarcinoma.Forty cases adenocarcinoma to 5 mm or less were examined detail.Mean patient age was 40.9 years. In 78% cases, midpoint focus region squamocolumnar junction transformation zone; more than 1 present 4 cases. Eighty-five percent also had situ (AIS). 9 10 minimally small glands stroma adjacent AIS. some...
To test the ThinPrep Processor for fine needle aspiration.One hundred unfixed, surgically removed specimens were aspirated. One pass was directly smeared, fixed and stained with Papanicolaou technique. The other rinsed in a proprietary fixative, single slide made. Smears diagnosed without knowledge of histologic diagnosis.Cellularity architectural integrity cell groups superior on conventional slides. Preservation detail both epithelial stromal cells Processor. background material, such as...
The clinical and histologic findings in 10 patients, 15-20 years of age, with complex hyperplasia or well-differentiated adenocarcinoma the endometrium are presented. morphologic distinction between two lesions is discussed, frequency misdiagnosis this form as carcinoma age group emphasized. No difference was found behavior series cases whether not a hysterectomy performed.
A chemotherapy response score (CRS) system was recently described to assess the histopathologic and prognosis of patients with tubo-ovarian high-grade serous carcinoma (HGSC) receiving neoadjuvant chemotherapy. The current study performed as an independent assessment this CRS system. We retrospectively identified advanced stage HGSC who received underwent interval debulking. If available, a hemotoxylin eosin slide from omentum adnexa selected for study. Slides were independently scored by 13...
Purpose: To determine the amount of waste produced from phacoemulsification surgeries and ways to curtail problem. Setting: Miri Hospital, Sarawak, Malaysia. Design: Prospective study. Methods: Phacoemulsification surgery cases were included in this study; nonphacoemulsification excluded. The was subdivided into 3 main categories, general waste, clinical sharps. by ophthalmologists trainees accounted for separately. mean weight per case obtained dividing total with number cases. Results: a...
The sensitivity of cervical smears for adenocarcinoma in situ (AIS) is not known, nor it known whether false-negative are due to sampling or screening interpretive errors. In 16 34 patients with AIS, 38 negative were reported 2 weeks 7 years before biopsy. Thirty-one these rescreened, and 17 (55%) retrospectively diagnosed as abnormal. Ten the had numerous well-preserved AIS cells: 5 very small, crowded cells, possibly originally mistaken endometrial large groups which cells resembled...
The epithelial cells of ovarian mucinous carcinomas may sometimes appear similar to those gastrointestinal or endocervical carcinomas, but most are composed that do not suggest any particular derivation. We report four cases carcinoma in which the were entirely almost endocervical-like. patients' ages 34, 43, 44, and 50 years. Two patients had bilateral tumors confined ovaries at initial staging; both also synchronous endometrial type. two other unilateral tumors, with invasive metastases...
We explored the possible pathogenetic pathway for mucinous ovarian tumorigenesis by examining k-ras mutational patterns in tumors (OMTs) with benign, borderline, and invasive epithelium which different types of are close proximity. Sixteen patients borderline (OMBTs) 4 grade 1 adenocarcinomas (OMCs) were selected presence a single histologic section contained clear “transition” zone from benign to epithelium, four cases, epithelium. A PixCell II Laser Capture Microscope was used microdissect...
Cases of atypical glandular cells (AGC) diagnosed on liquid-based preparations were culled from a 3-year period. When available, residual cellular material was analyzed for human papillomavirus (HPV) by polymerase chain reaction and correlated with cytologic histologic (biopsy) outcome. Of 178,994 cases, 187 (0.1045%) contained AGC compared 8,740 (4.8828%) squamous (ASC) an AGC/ASC ratio 0.021. HPV results follow-up available 108 specimens 106 patients. Depending the end-point...