A5065779645- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Quinazolinone synthesis and applications
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Biochemical effects in animals
- Synthesis and Reactions of Organic Compounds
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Neurological Disorders and Treatments
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Adenosine and Purinergic Signaling
- Computational Drug Discovery Methods
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antiplatelet Therapy and Cardiovascular Diseases
- Multicomponent Synthesis of Heterocycles
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Chromatography
- Neonatal Health and Biochemistry
- Analytical Methods in Pharmaceuticals
- Magnesium in Health and Disease
- Chemical synthesis and pharmacological studies
- Traumatic Brain Injury and Neurovascular Disturbances
Volgograd State Medical University
2012-2023
Ministry of Health of the Russian Federation
2017-2023
Southern Federal University
2022
Institute of Pharmacology
2008
The Na+/H+ exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic anti-inflammatory properties NHE-1 inhibitors. Herein we report novel inhibitors realized via functionalization N1-alkyl quinazoline-2,4(1H,3H)-dione quinazoline-4(3H)-one with N-acylguanidine or 3-acyl(5-amino-1,2,4-triazole) side chain. Lead compounds show activity in nanomolar range. Their...
Quinazolines are a rich source of bioactive compounds. Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for series quinazoline-2,4(1H,3H)-diones quinazoline-4(3H)-one guanidine derivatives. In the present work, novel N1,N3-bis-substituted quinazoline-2,4(1H,3H)-dione derivatives bearing two moieties were synthesized pharmacologically profiled. The most potent inhibitor 3a also possesses antiplatelet...
Sodium-hydrogen exchanger (Na + /H ) type 1 (NHE-1) inhibitors have been shown to protect the heart during ischaemia and early reperfusion.As such, NHE-1 are of special interest for clinical development attenuation both acute chronic post-myocardial infarction responses.New pyrimidine derivatives N-acetylguanidine containing fragments uracil, thymine, their 3-benzyl were synthesised.These compounds showed in vitro inhibitory effects on that significantly higher than those zoniporide platelet...
Introduction: Na+/H+ exchanger type 1 (NHE-1) is a validated drug target for the treatment of cardiovascular and ophthalmic diseases due to cytoprotective, anti-ischemic anti-inflammatory properties NHE-1 inhibitors. This article presents data on synthesis pharmacological activity studies novel guanidine derivatives quinazoline-2,4(1H,3H)-dione 6-11 reference drugs amiloride, rimeporide, zoniporide, dexamethasone, aminoguanidine, acetylsalicylic acid. Materials Methods: Pharmacological were...
ВЛИЯНИЕ ИНГИБИТОРОВ NHE-1 ЗОНИПОРИДА И ВМА-1321 НА УРОВЕНЬ ПРОДУКТОВ ПЕРЕКИСНОГО ОКИСЛЕНИЯ ЛИПИДОВ ФЕРМЕНТОВ АНТИОКСИДАНТНОЙ СИСТЕМЫ В МИТОХОНДРИЯХ СЕРДЦА ЖИВОТНЫХ С ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ
Advanced glycation end-products play an important role in the development of diabetic complications, so slowing down glycated proteins’ cross-links formation have been suggested as a potential therapeutic option for treatment vascular complications and preventing their progression. The aim work was to assess influence novel anticrosslinking agent DF-5 on renal advanced collagen contents, body weight, blood glucose hemoglobin levels early disease streptozotocin-induced rats. Materials...