A5007347632- Enzyme Catalysis and Immobilization
- Immune cells in cancer
- Biofuel production and bioconversion
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Biomedical and Engineering Education
- Catalysis for Biomass Conversion
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Enzyme Production and Characterization
- Single-cell and spatial transcriptomics
- Innovative Teaching Methods
- Dermatology and Skin Diseases
- Adolescent and Pediatric Healthcare
- Cancer Cells and Metastasis
- Engineering Education and Curriculum Development
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Electrochemical sensors and biosensors
- Delphi Technique in Research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Cancer, Lipids, and Metabolism
- Psoriasis: Treatment and Pathogenesis
University of Michigan
2018-2024
Immunomodulators that remodel the tumor immunosuppressive microenvironment have been combined with anti–programmed death 1 (α-PD1) or ligand (α-PDL1) immunotherapy but shown limited success in clinical trials. However, therapeutic strategies to modulate of lymph nodes largely overlooked. Here, we designed an albumin nanoparticle, Nano-PI, containing immunomodulators PI3Kγ inhibitor (IPI-549) and paclitaxel (PTX). We treated two breast cancer mouse models Nano-PI combination α-PD1, which...
Current cancer vaccines using T cell epitopes activate antitumor immunity through dendritic cell/macrophage-mediated antigen presentation, but they lack the ability to promote B/CD4 crosstalk, limiting their anticancer efficacy. We developed antigen-clustered nanovaccine (ACNVax) achieve long-term tumor remission by promoting crosstalk. The topographic features of ACNVax were achieved an iron nanoparticle core attached with optimal number gold nanoparticles, where clusters HER2 conjugated on...
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTEngineering Spatially Organized Multienzyme Assemblies for Complex Chemical TransformationLuke F. BugadaLuke BugadaDepartment of Engineering, University Michigan, Ann Arbor, Michigan 48109, United StatesMore by Luke Bugada, Mason R. SmithMason SmithDepartment Smith, and Fei Wen*Fei WenDepartment States*E-mail: [email protected]More Wenhttp://orcid.org/0000-0001-7970-4796Cite this: ACS Catal. 2018, 8, 9, 7898–7906Publication Date (Web):July 17,...
Over the past decade, increasingly globalized society has continually redefined qualities and skills of an ideal engineering graduate for industry academic careers, and, more recently, in light a global pandemic 2020, pedagogical environment shifted toward virtual classroom setting. Because social challenges modern world are rapidly evolving, it is important to adapt teaching methods that reflect these changing times. An attractive method project-based learning (PBL), which known improve...
Influenza poses a persistent health burden worldwide. To design equitable vaccines effective across all demographics, it is essential to better understand how host factors such as genetic background and aging affect the single-cell immune landscape of influenza infection. Cytometry by time-of-flight (CyTOF) represents promising technique in this pursuit, but interpreting its large, high-dimensional data remains difficult. We've developed new analytical approach iGATE (in-silico gating...
Despite promising developments in computational tools, peptide-class II MHC (MHCII) binding predictors continue to lag behind their I counterparts. Consequently, peptide-MHCII is often evaluated experimentally using competitive assays, which tend sacrifice throughput for quantitative detail. Here, we developed a high-throughput semiquantitative screening strategy termed microsphere-assisted peptide (MAPS) that aims balance the accuracy of assays with tools. Using MAPS, screened library from...