A5040119864- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac, Anesthesia and Surgical Outcomes
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Chemokine receptors and signaling
- Receptor Mechanisms and Signaling
- Surgical Simulation and Training
- Sepsis Diagnosis and Treatment
- History of Science and Medicine
- Hernia repair and management
- Cardiovascular Function and Risk Factors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Esophageal and GI Pathology
- Innovations in Medical Education
- Advanced Breast Cancer Therapies
- Cardiac Valve Diseases and Treatments
- Artificial Intelligence in Healthcare and Education
- History of Science and Natural History
- Anatomy and Medical Technology
- Neuroblastoma Research and Treatments
- Bone health and osteoporosis research
- Neuroendocrine Tumor Research Advances
- Myasthenia Gravis and Thymoma
- Gastroesophageal reflux and treatments
University of Washington
2009-2025
University of South Florida
2012-2024
Tampa General Hospital
2021-2022
Rogers (United States)
2022
Barrow Neurological Institute
2021
Northwestern University
2002-2008
Ospedale SS. Annunziata
2007
Azienda Ospedaliera G. Brotzu
2007
University of Konstanz
1995
National Institute for Medical Research
1993
To determine if glucose management in postcardiothoracic surgery patients with a combined intravenous (IV) and subcutaneous (SC) insulin regimen reduces mortality morbidity diabetes stress-induced hyperglycemia.Retrospective review of 614 consecutive who underwent cardiothoracic (CT) 2005 was performed to evaluate the incidence treatment postoperative hyperglycemia operative mortality. Hyperglycemic (glucose >6.05 mmol/l) were treated IV intensive care unit (ICU) followed by SC (outside...
Summary: Purpose: Evidence suggests that enzyme‐inducing antiepileptic drugs (AEDs) may decrease serum 25‐hydroxyvitamin D (25‐OHD) levels and increase bone turnover. We sought to determine whether these are affected by treatment with carbamazepine (CBZ) or oxcarbazepine (OXC). Methods: measured of 25‐OHD, parathyroid hormone (PTH), osteocalcin (OCLN), alkaline phosphatase (BAP), urinary N‐telopeptides type I collagen cross‐links (NTX) in normal controls (n = 24) epilepsy patients taking CBZ...
Accurate lineage identification of pituitary neuroendocrine tumors (PitNETs) is critical to inform our understanding tumor biology and aggressiveness. While this was previously performed using immunohistochemistry for anterior hormones, the recent WHO update specific transcription factors (PIT-1, SF-1, TPIT) has led improved classification PitNETs. Although TPIT, a T-box factor, afforded corticotroph PitNETs from what were thought be null cell adenomas, standardization factor staining yet...
1. Pharmacological evidence suggests L‐glutamate is a strong candidate as transmitter at the giant synapse of squid. Postsynaptic activation cannot be effected by conventional application putative neurotransmitters iontophoresis or perfusion, apparently because complex structure prevents sufficiently rapid change in concentration postsynaptic membrane. Flash photolytic release from pharmacologically inert ‘caged’ pre‐equilibrated stellate ganglion Alloteuthis Loligo was used to determine...
One hundred and fourteen patients operated on for an intracranial aneurysm were followed up in order to investigate their neuropsychological outcome detect if there any clinical features assessed around the time of operation that had prognostic significance. The examination evaluated language, apraxia, memory, intelligence spatial ability. In statistical analysis overall severity disorder was studied. "Late surgery timing" a negative influence upon outcome. There not difference between...
The neuropeptide proctolin in nanomolar concentrations enhances the contraction of crustacean muscle fibers manyfold. cellular mechanisms underlying this potentiation were investigated single, isolated, fast-contracting abdominal extensor a small crustacean, marine isopod Idotea baltica. Force measurements and current-clamp experiments revealed two actions on fibers. In half preparations, (10(-9)-10(-6) M) increased fiber's input resistance by up to 25%. about one-fourth induced all-or-none...
In patients undergoing high-risk cardiac surgery, the uncertainty of outcome may complicate decision process to intervene. To augment decision-making, a machine learning approach was used determine weighted personalized factors contributing mortality.American College Surgeons National Surgical Quality Improvement Program queried for surgery with predicted mortality ≥10% between 2012 and 2019. Multiple models were investigated, significant predictors ultimately in gradient boosting (GBM)...
The chemokine receptor CXCR4, a G protein–coupled (GPCR) capable of heteromerizing with other GPCRs, is involved in many processes, including immune responses, hematopoiesis, and organogenesis. Evidence suggests that CXCR4 activation reduces thrombin/protease-activated 1 (PAR1)-induced impairment endothelial barrier function. However, the mechanisms underlying cross-talk between PAR1 are not well-understood. Using intermolecular bioluminescence resonance energy transfer proximity ligation...
Capnocytophaga sputigena is rarely implicated as the cause of postsurgical intra-abdominal abscess because it almost exclusively found in oral flora. Despite its rarity infection, there are examples this atypical presentation, and an awareness organism a potential etiology surgical infection relevant for both obstetric general surgeons. We report case young female who presented just over week after uncomplicated C-section with complaint abdominal discomfort fevers. Imaging revealed multiple...
Although class A seven-transmembrane helix (7TM) receptor hetero-oligomers have been proposed, information on the assembly and function of such higher-order is not available. Utilizing bioluminescence resonance energy transfer (BRET), bimolecular luminescence/fluorescence complementation (BiLC/BiFC), BiLC/BiFC BRET in HEK293T cells, we provide evidence that chemokine (C-X-C motif) 4, atypical 3, α1a -adrenoceptor, arginine vasopressin 1A form composed 2-4 different protomers. We show...
Previously, we reported that chemokine (C‐C motif) receptor 2 (CCR2) heteromerizes with α 1B ‐adrenoceptor (α ‐AR) in leukocytes, through which ‐AR controls CCR2. Whether such heteromers are expressed human vascular smooth muscle cells (hVSMCs) is unknown. Bioluminescence resonance energy transfer confirmed formation of recombinant CCR2:α 1b heteromers. Proximity ligation assays detected hVSMCs and mesenteric arteries. heteromerization per se enhanced ‐AR‐mediated Gα q ‐coupling. Chemokine...
Abstract We compared therapeutic properties of natural and engineered chemokine (C-X-C motif) receptor 4 (CXCR4) agonists in a rat acute respiratory distress syndrome (ARDS) model utilizing the PaO 2 /FiO -ratio as clinically relevant primary outcome criterion. Ventilated rats underwent unilateral lung ischemia from t = 0–70 min plus hemorrhage to mean arterial blood pressure (MAP) 30 mmHg 40–70 min, followed by reperfusion/fluid resuscitation until 300 min. Natural CXCR4 (CXCL12, ubiquitin)...
Objective Patients of low socioeconomic status have an increased risk complications following cardiac surgery. We aimed to identify disparities in patients undergoing aortic valve replacement using the Distressed Communities Index (DCI), a comparative measure community well-being. The DCI incorporates seven distinct indicators into single composite score depict economic well-being community. Methods Healthcare Cost and Utilization Project State Inpatient Database (HCUP-SID) for Florida...