Lion Sieg

ORCID: 0000-0002-0756-893X
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About
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Research Areas
  • Organ Transplantation Techniques and Outcomes
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Cardiac Arrest and Resuscitation
  • Liver Disease and Transplantation
  • Patient Safety and Medication Errors
  • Simulation-Based Education in Healthcare
  • Trauma and Emergency Care Studies
  • Airway Management and Intubation Techniques
  • Blood transfusion and management
  • Liver physiology and pathology
  • Central Venous Catheters and Hemodialysis
  • Clinical Reasoning and Diagnostic Skills
  • Emergency and Acute Care Studies
  • Clinical practice guidelines implementation
  • Organ Donation and Transplantation
  • Cardiac, Anesthesia and Surgical Outcomes
  • Medical Practices and Rehabilitation
  • Xenotransplantation and immune response
  • Acute Ischemic Stroke Management
  • Healthcare professionals’ stress and burnout
  • Nursing Roles and Practices
  • Healthcare Systems and Reforms
  • Liver Disease Diagnosis and Treatment
  • Team Dynamics and Performance
  • Hydraulic Fracturing and Reservoir Analysis

Medizinische Hochschule Hannover
2016-2022

German Society of Medical Intensive Care and Emergency Medicine
2022

Videolaryngoscopy has been proven to be a safe procedure managing difficult airways in the hands of airway specialists. Information about success rates unexperienced users videolaryngoscopy compared conventional laryngoscopy is sparse. Therefore, we aimed evaluate if there might more securing an provider using videolaryngoscope simulated randomized manikin study. Differences between commonly used videolaryngoscopes were elucidated. A standardized hands-on workshop prior study was performed....

10.1186/s40001-017-0268-7 article EN cc-by European journal of medical research 2017-08-10

Increased transfusion requirements in liver transplantation have been reported to be associated with worsened outcomes, more frequent reinterventions, and higher expenses. Anesthesiologists might counteract this through improved coagulation management. We evaluated the effects of rotational thromboelastometry on product outcome measurements.Patients who were 14 years or older undergoing transplant at Hannover Medical School between January 2005 December 2009 included retrospective analysis....

10.6002/ect.2017.0236 article EN Experimental and Clinical Transplantation 2019-04-01

In the era of organ machine perfusion, experimental models to optimize reconditioning (marginal) liver grafts are needed. Although relevance cytokine signatures in transplantation has been analyzed previously, significance molecular monitoring during normothermic perfusion (NMP) remains elusive. Therefore, we developed a porcine model cold ischemic graft injury after prolonged static storage (SCS) and subsequent NMP: Livers obtained from ten minipigs underwent NMP for 6 h directly...

10.3389/ti.2022.10712 article EN cc-by Transplant International 2022-10-20

Introduction Despite advances in perioperative management and surgical technique, postoperative liver failure remains a feared complication after hepatic resection. Various supportive treatment options are under current discussion, but lack of structured evaluation. We therefore established porcine model major resection to study regeneration partial hepatectomy reliable well-defined pre-clinical setting. Methods Major was performed on seven minipigs with the intention set up non-lethal...

10.1371/journal.pone.0217488 article EN cc-by PLoS ONE 2019-05-31

The use of these agents is common in the prehospital as well hospital setting and application topical haemostatics reported 9-11 .

10.20431/2455-9792.0204002 article EN ARC Journal of Anesthesiology 2017-01-01

Background: Twenty-five to 85% of trauma patients are under the influence alcohol in addition experiencing injury-related coagulation impairment. Viscoelastic point-of-care tests (thrombelastography [TEG], rotational thromboelastometry [ROTEM]) popular tools for rapid hemostasis assessment and therapeutic decision-making this other settings. While affects these in-vitro, their specific effects in-vivo unclear. Therefore, we evaluated ingestion on ROTEM parameters.Methods: Twenty volunteers...

10.4097/kja.20071 article EN cc-by-nc Korean journal of anesthesiology 2020-04-17

Objective: The psychological demands placed upon the emergency medical services, assures them of their place amongst High Responsibility Organizations. A high pressure to act and an irreversibility situations are integral features workplaces. After services' job profiles were restructured in Germany, practical stage paramedic training is now undertaken these conditions. That is, they trained by a supervising instructor whilst caring for critically ill patients. This paper aims describe...

10.3205/zma001216 article EN DOAJ (DOAJ: Directory of Open Access Journals) 2019-01-01

Individuals have different qualities, levels of willingness, and degrees engagement for working in teams. This behaviour is termed 'Collective Orientation' (CO). Collective orientation can be trained has a positive influence on team processes. Here, we investigated the effect simulator-based, Crisis Resource Management training upon participants' CO.We hypothesized (1) scales CO Presence lab-based microworld research (PLBMR) are applicable to German anaesthesia teams, (2) influenced by means...

10.1177/2382120520931773 article EN cc-by-nc Journal of Medical Education and Curricular Development 2020-01-01

The indication of hydroxyethyl starch is currently under critical discussion and albumin 5% (ALB) has an increasing use in the operating theatre. Therefore, ALB routinely used neurosurgical procedures often combined with mannitol 20% (MAN). Purpose this in-vitro study was to determine influence combination MAN on blood coagulation platelet function.Twenty-two healthy volunteers were included into 21 analyzed. Blood obtained diluted five groups: 1) 7% dilution MAN; 2) 10% ALB; 3) 17% isotonic...

10.23736/s0390-5616.19.04679-4 article EN Journal of Neurosurgical Sciences 2022-01-21

Hepatocyte transplantation (HTx) is regarded as a potential treatment modality for various liver diseases including acute failure. We developed preclinical pig model to evaluate if HTx could safely support recovery from function impairment after partial hepatectomy.Pigs underwent hepatectomy with reduction of the volume by 50% induce transient but significant function. Thereafter, 2 protocols were evaluated and compared control group receiving resection only (group 1, n = 5). Portal...

10.1159/000516690 article EN cc-by-nc European Surgical Research 2021-01-01

Emergency medical services work in the environment of high responsibility teams and have to act under unpredictable working conditions. Stress occurs has potential negative effects on tasks, teamwork, prioritization processes cognitive control. is not exclusively dictated by situation-the individuals rate situation having necessary skills that a particular demands. There are different occupational groups emergency Germany. Training, tasks legal framework these vary.The aim this study was...

10.1007/s00101-021-00968-x article EN cc-by Der Anaesthesist 2021-05-11

Zusammenfassung Hintergrund Eine hohe Versorgungsqualität in der präklinischen Notfallmedizin zeichnet sich durch eine leitliniengerechte Therapie aus. Grundvoraussetzung für diese ist das Vorhalten benötigten Medikamente entsprechend den gültigen Leitlinienempfehlungen. Ob dies flächendeckend gewährleistet wird, aktuell unklar. Ein einheitlicher Standard zur medikamentösen Ausstattung arztbesetzter Rettungsmittel Deutschland existiert nicht. Ziel vorliegenden Arbeit die Identifikation von...

10.1007/s10049-022-01036-6 article DE cc-by Notfall + Rettungsmedizin 2022-05-13

Liver transplantation is a complex intervention, and early anticipation of personnel logistic requirements great importance. Early identification high-risk patients could prove useful. We therefore evaluated prognostic values recipient parameters commonly available in the preoperative stage regarding postoperative 30- 90-day outcomes intraoperative transfusion liver transplantation.All adult undergoing first at Hannover Medical School between January 2005 December 2010 were included this...

10.1177/1526924818765805 article EN Progress in Transplantation 2018-03-20
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