In spite of renal graft shortage and increasing waiting times for transplant candidates, simultaneous heart kidney transplantation (HKTx) is an increasingly performed procedure established patients with combined end-stage cardiac failure. Although data on outcome in this setting limited, reports reduced survival comparison to solitary (KTx) have led ongoing discussion adequate organ utilization.This retrospective study was conducted evaluate prognostic factors outcomes 27 undergoing HKTx a...

Abstract In contrast to the whole liver, primary hepatocytes are highly immunogenic. Thus, alternative strategies of immunomodulation after hepatocyte transplantation special interest. Silencing HLA class I expression is expected reduce strength allogeneic immune responses and improve graft survival. this study, human (PHH) were isolated using a two‐step‐collagenase perfusion‐technique co‐cultured with lymphocytes in terms mixed lymphocyte culture. Expression on PHH was silenced lentiviral...

Abstract Background Adenocarcinoma of the pancreatic body and tail is associated with a dismal prognosis. As patients frequently present themselves locally advanced tumors, extended surgery including multivisceral resection often necessary in order to achieve tumor-free margins. The aim this study was identify prognostic factors for postoperative morbidity mortality evaluate influence resections on patient outcome. Methods This retrospective analysis 94 undergoing adenocarcinoma located...

The field of pediatric kidney transplantation remains challenging due to an ongoing lack size-matched grafts and anatomical peculiarities. In the current study, we investigated incidence surgical complications in recipients, with a focus on risk factors effects graft outcome. We retrospectively reviewed all 2386 transplantations at our institution from January 2005 until December 2018. Of these, 221 transplants were performed defined as under age 18 years. Donor-recipient body surface area...

The acquisition of surgical skills requires motor learning. A special form this is intermanual transfer by transferring from the nondominant hand (NDH) to dominant (DH). purpose study was determine learning gains that can be achieved for DH training with DH, NDH, and non-surgical alternative (AT).124 preclinical (n=62) clinical dental students completed knot tying suturing technique an AT in a controlled randomized trial.A statistically significant gain suture evident only after when...

Aim: Postoperative adhesions cause medical and socio-economic problems. 4DryField PH (4DF) is a starch-based product/agent with approved anti-adhesive haemostatic effects. However, the influence on anastomotic healing has not yet been evaluated. The purpose of this study was, therefore, to characterize effects intraoperatively applied 4DF incidence leakage (AL) after rectal surgery. Methods: In retrospective, monocentric cohort study, 157 patients surgery primary anastomosis were divided...

Abstract Background Laparoscopic techniques have been successfully implemented for living kidney donation. However, open surgical procedures also yield excellent perioperative outcomes. Endoscopic donor nephrectomy is associated with minimal trauma but difficult right-sided nephrectomies. Here, an approach using a singular pararectal extraperitoneal mini-incision (SPEM) and the results are presented to elucidate whether surgery still justified in modern era of endoscopic surgery. Methods In...

Despite the introduction of novel targeted therapies on patients with renal cell carcinoma, syn- and metachronous metastases (including hepatic lesions) are observed frequently significantly influence patient survival. With as an effective alternative to surgery, therapeutical strategies in stage IV disease must be reevaluated.This is a retrospective analysis 40 undergoing resection histologically confirmed RCC at our institution between April 1993 2017.The interval nephrectomy for carcinoma...

Abstract Purpose The incidence of intrahepatic cholangiocarcinoma is increasing worldwide. Despite advances in surgical and non-surgical treatment, reported outcomes are still poor resection remains to be the only chance for long-term survival affected patients. identification validation prognostic factors scores, such as recently introduced severity index, postoperative morbidity mortality essential facilitate optimal therapeutic regimens. Methods This a retrospective analysis 269 patients...

We report a case of 60-year-old male patient with recurrent episodes free gas in the peritoneal and retroperitoneal cavities as well pneumatosis intestinalis 3 months after bilateral lung transplant. Interestingly, despite staged laparotomy within scope first episode, no cause for could be found. In second episode symptomatically pneumatosis, conservative treatment metro_nidazole was performed successfully. Despite several reports on patients transplant, an effective strategy has not yet...

In the era of organ machine perfusion, experimental models to optimize reconditioning (marginal) liver grafts are needed. Although relevance cytokine signatures in transplantation has been analyzed previously, significance molecular monitoring during normothermic perfusion (NMP) remains elusive. Therefore, we developed a porcine model cold ischemic graft injury after prolonged static storage (SCS) and subsequent NMP: Livers obtained from ten minipigs underwent NMP for 6 h directly...

Introduction Despite advances in perioperative management and surgical technique, postoperative liver failure remains a feared complication after hepatic resection. Various supportive treatment options are under current discussion, but lack of structured evaluation. We therefore established porcine model major resection to study regeneration partial hepatectomy reliable well-defined pre-clinical setting. Methods Major was performed on seven minipigs with the intention set up non-lethal...

Rejection of solid organ grafts is regarded to be dependent on T cell responses. Nonetheless, numerous studies have focused the contribution NK cells in this process, resulting contradictory theories. While some conclude that there no participation cells, others found an inflammatory or regulative role cells. However, experimental settings are rarely comparable with regard challenged species, strain combinations nature graft. Thus, clear definition might impeded by these circumstances. In...

This study was performed to evaluate the incidence and outcome of patients with ventricular assist devices (VADs) undergoing abdominal surgery at our institution. A total 604 adult who underwent VAD implantation between February 2004 2018 were analyzed retrospectively a median follow-up time 66 (6-174) months. Thirty-nine (6.5%) surgery. Elective surgical procedures in 22 (56.4%), mainly for wall hernia repairs, partial colectomies, cholecystectomies. Early after elective no patient died,...

Background: Patients with extrahepatic cholangiocarcinoma (CCA) face considerable morbidity including septic complications after surgery. The aim of this study was to characterize the bacterial spectrum common hepatic duct (CHD) and its clinical relevance regarding mortality resection CCA. Methods: We retrospectively analyzed data from 205 patients undergoing surgery for CCA in our department between January 2000 March 2015. were reviewed pre-operative medical conditions, biliary flora...

Hepatocyte transplantation (HTx) is regarded as a potential treatment modality for various liver diseases including acute failure. We developed preclinical pig model to evaluate if HTx could safely support recovery from function impairment after partial hepatectomy.Pigs underwent hepatectomy with reduction of the volume by 50% induce transient but significant function. Thereafter, 2 protocols were evaluated and compared control group receiving resection only (group 1, n = 5). Portal...

The rapidly aging population in industrialized countries comes with an increased incidence of intrahepatic cholangiocarcinoma (iCC) which presents new challenges for oncological treatments especially elderly patients. Thus, the question arises to what extent benefit surgical resections, as only curative treatment option, outweighs possible perioperative risks patients ≥ 80 years age (octogenarians). We therefore retrospectively analyzed 311 who underwent resection iCC at Hannover Medical...