A5104454587- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Thyroid Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic Syndromes and Imprinting
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- T-cell and B-cell Immunology
- Thyroid and Parathyroid Surgery
- Hematological disorders and diagnostics
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Pluripotent Stem Cells Research
- Surgical Sutures and Adhesives
- Central Venous Catheters and Hemodialysis
Medizinische Hochschule Hannover
2009-2023
St. Elisabeth-Hospital Bochum
2023
American Society of Transplantation
2006
Emory University
2004-2006
Renal dysfunction caused by treatment with the calcineurin inhibitors (CNI) is a major problem in long-term course after liver transplantation.In 22 graft recipients renal and stable function between 3 weeks 12 years transplantation, CNI were substituted MMF at final dose of 1.5-3 g/day October 1996 1998.In prospective non-randomized study, development function, side effects medication, stability analyzed for mean follow-up 15 months. Results. (1) was withdrawn four patients 1 7 months study...
The objective of this study was to determine whether the use recombinant human TSH (rhTSH) stimulate radioiodine uptake after thyroidectomy is as efficacious a period withholding thyroid hormones, while at same time avoiding hypothyroidism, reducing sick leave and shortening hospital stay.Our aim compare standard procedure differentiated cancer treatment, which consists followed by 4 weeks hypothyroidism conclusive ablative activity (131)iodine, with new shortened treatment in l-thyroxine...
BACKGROUND:Increasing scarcity of donated liver grafts clearly demonstrates the desperate need for ongoing outcome analysis to improve patient and graft survival after transplantation. Coagulation is often severely deteriorated in patients suffering from disease, thus leading bleeding complications MATERIAL AND METHODS:We included 770 transplantations this single-center retrospective identify independent risk factors post-operative hemorrhage. The relevance was assessed with special regards...
Post-transplant lymphoproliferative disorder (PTLD) adversely affects patients' long-term outcome. The paired t test and McNemar's were applied in a retrospective 1:1 matched-pair analysis including 36 patients with PTLD without after kidney or liver transplantation. Matching criteria age, gender, indication, type of transplantation, duration follow-up. All investigated specimen histologically positive for EBV. Risk-adjusted multivariable regression was used to identify independence risk...
Parathyroidectomy (PT) corrects tertiary hyperparathyroidism in patients who have received renal grafts but can result deterioration of function.To compare different surgical procedures for their effect on function and efficacy to cure hyperparathyroidism.A retrospective cohort study.University clinic.Eighty-three with functioning receiving PT the first time.Group 1 an incomplete PT, at least entire parathyroid gland (PG) remaining situ (n = 12). Group 2 most morphologically conserved PG...
Continuous bleeding after using conventional hemostatic methods involving energy, sutures, or clips, is a serious and costly surgical complication. Many topical agents have been developed to promote intraoperative hemostasis, but improvement needed in both decreasing time hemostasis increasing ease of use. Veriset™ patch CE-marked for controlling on the liver soft tissue. In current study, we aimed gather further evidence safety effectiveness tissue during variety procedures.Thirty patients...
Background. This retrospective cohort study evaluates the advantages of risk balancing between prolonged cold ischemic time (CIT) and late night surgery. Methods. 1262 deceased donor kidney transplantations were analyzed. Multivariable regression was used to determine odds ratios (ORs) for reoperation, graft loss, delayed function (DGF), discharge on dialysis. CIT categorized according a forward stepwise pattern ≤1 h />1 h, ≤2 />2 ≤3 />3 <mml:math...
Background. Infusion of donor dendritic cells (DC) has been shown to prolong allograft survival in a number models. However, many regimens that utilize DC do not consistently produced tolerance or long-term survival. We hypothesized one factor limiting the therapeutic effect is their relative inability traffic recipient peripheral lymph nodes and inhibit function resident alloreactive T cells. Methods. Donor strain isolated from spleens bone marrow Flt3L-treated mice were transferred...
Introduction. Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery. Replacing by recombinant human stimulating hormone can facilitate euthyroidism within one week The outcome this approach was investigated. Methods. This is a prospective randomized trial to compare few days preconditioning with versus separated four L-T4 withdrawal. Tumors were graded into very low-, low- , or high-risk tumors. Recurrence-free...
Colonoscopy is one of the most frequently performed elective and invasive diagnostic interventions. For every colonoscopy, complete colon preparation mandatory to provide best possible endoluminal visibility; for example, patient has drink a great volume non-resorbable solution flush out all feces. Despite known nauseating side effects colonoscopy despite knowledge that excessive vomiting can cause rupture distal esophagus (Boerhaave syndrome), which rare but severe complication with high...
Background. This is a single center oncological resume overlooking four decades of experience with liver transplantation (LT) for hepatocellular carcinoma (HCC). Methods. All 319 LT HCC that were performed between 1975 and 2011 included. Predictors recurrence (HCCR) survival identified by Cox regression, Kaplan-Meier analysis, Log Rank, and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mi>χ</mml:mi></mml:mrow><mml:mrow><mml:mn...
This study aimed to evaluate whether the Glasgow Prognostic Score (GPS) and its variants are able predict mortality in live donor deceased liver transplantation for hepatocellular carcinoma.Data of 29 319 transplantations from two German transplant centers was analyzed. The GPS, modified hepatic Abe score were investigated. Receiver operating characteristic (ROC) curve analysis carried out calculate sensitivity, specificity, overall model correctness investigated scores as a predictive...
BACKGROUND Prognostic models for 3-year mortality after kidney transplantation based on pre-transplant donor and recipient variables may avoid futility thus improve organ allocation. MATERIAL AND METHODS There were 1546 consecutive deceased-donor transplants in adults (January 1, 2000 to December 31, 2012) used identify with significant independent influence long-term survival (Cox regression modelling). Detected factors develop a prognostic model 1289 patients follow-up of >3 years...
<b><i>Background/Aims:</i></b> Postsurgical gastroesophageal intrathoracic leakage is a potentially life-threatening condition that frequently accompanied by mediastinitis and subsequent sepsis. Aspiration of fluids from leaks during endoscopy for microbiological analysis rarely performed in clinical routine. The aim was to evaluate the role routine via its impact on antibiotic therapy. <b><i>Methods:</i></b> This a<b>...
The development of protocols to induce a state durable mixed allogeneic hematopoietic chimerism confer robust donor-specific transplant tolerance has been major focus the community for past decade. High levels across full histocompatibility complex (MHC) barrier can be achieved by total myeloablation and transfusion host donor bone-marrow cells (1) or, as shown more recently, with nonmyeloablative preconditioning regimes in combination transfusions (2-4) or purified stem (HSC) (5-7). Here we...
The concept of high-urgency (HU) renal transplantation was introduced in order to offer patients, who are not able undergo long-term dialysis treatment, a suitable graft short period time, overcoming by this way the obstacle prolonged time spent on waiting list. goal study evaluate patient and survivals after HU compare them outcomes non-high-urgency transplant recipients. clinical course 33 recipients operated at our center between 1995 2010 retrospectively analyzed. major indication for...