A5013224767- Proteoglycans and glycosaminoglycans research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Glioma Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Glycosylation and Glycoproteins Research
- Folate and B Vitamins Research
- Ubiquitin and proteasome pathways
- Caveolin-1 and cellular processes
- Single-cell and spatial transcriptomics
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Hearing, Cochlea, Tinnitus, Genetics
- Protease and Inhibitor Mechanisms
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Heme Oxygenase-1 and Carbon Monoxide
- Mathematical Biology Tumor Growth
Uppsala University
2014-2025
All India Institute of Medical Sciences, Deoghar
2025
R. G. Kar Medical College and Hospital
2017-2021
Science for Life Laboratory
2012-2020
Institute of Post Graduate Medical Education and Research
2011-2020
Medical College and Hospital, Kolkata
2012-2015
University of Louisville
2008-2009
University of Louisville Hospital
2008
Toronto Western Hospital
1999
Homocysteine (Hcy) causes cerebrovascular dysfunction by inducing oxidative stress. However, to date, there are no strategies prevent Hcy-induced damage. Hcy is an H2S precursor formed from methionine (Met) metabolism. We aimed investigate whether ameliorated Met-induced stress in mouse brain endothelial cells (bEnd3). The bEnd3 were exposed Met treatment the presence or absence of NaHS (donor H2S). cell toxicity increased levels free radicals a concentration-dependent manner....
Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents complex spectrum of genomic aberrations, but the pharmacological consequences these aberrations are partly unknown. Here, we report an integrated pharmacogenomic analysis 100 patient-derived GBM cell cultures from human glioma culture (HGCC) cohort. Exploring 1,544 drugs, find that has two main subgroups, marked by differential response to proteasome inhibitors and mutually exclusive in TP53...
Secretion of pleiotrophin by aggressive gliomas triggers the formation abnormal blood vessels endothelial cells.
Malignant glioma continues to be fatal, despite improved insight into its underlying molecular mechanisms. The most malignant form, glioblastoma (GBM), is characterized by aberrant activation of receptor tyrosine kinases (RTK) and infiltrative growth. Heparan sulfate proteoglycans (HSPG), integral components the extracellular matrix brain tumors, can regulate many RTK pathways. This prompted us investigate heparanase (HPSE), which cleaves HSPGs, for role in glioma. hypothesis was evaluated...
Glioblastoma invasion into healthy brain tissue remains a major barrier to effective treatment, yet current models fail capture its full complexity in scalable and patient-specific manner. Here, we introduce GlioTrace, novel ex vivo imaging AI-based analytical framework that enables real-time, spatiotemporal tracking of glioblastoma dynamics patient-derived glioma cell culture xenograft (PDCX) slices. By integrating whole-specimen confocal microscopy, vascular counterstaining, an advanced...
<title>Abstract</title> Glioblastoma invasion into healthy brain tissue remains a major barrier to effective treatment, yet current models fail capture its full complexity in scalable and patient-specific manner. Here, we introduce GlioTrace, novel <italic>ex vivo</italic> imaging AI-based analytical framework that enables real-time, spatiotemporal tracking of glioblastoma dynamics patient-derived glioma cell culture xenograft (PDCX) slices. By integrating whole-specimen confocal microscopy,...
Glioblastoma (GBM) is a highly invasive and heterogeneous brain tumor, where distinct patterns of growth invasion critically influence disease progression therapy response. However, the molecular drivers these phenotypes remain poorly understood. Here, we present HGCC Phenobank, next-generation atlas 76 patient-derived GBM cases engrafted in mice, integrating histopathology, transcriptomics, epigenomics, proteomics. We identify two dominant modes-diffuse parenchymal spread...
According to the first population-based cancer registry from eastern part of India, Kolkata and its surrounding areas have highest prevalence lung in India. However, there is very limited data this country.The aim study find out demographic clinicoradiological profile primary bronchogenic carcinoma.This a retrospective review cases diagnosed two tertiary institutes over period 4 years.We reviewed with proven histological or cytological diagnosis carcinoma chi-square test done calculate...
New, effective treatment strategies for glioblastomas (GBMs), the most malignant and invasive brain tumors in adults, are highly needed. In this study, we investigated potential of integrin α10β1 as a therapeutic target GBMs. Expression levels role were studied patient-derived GBM tissues cell lines. The effect an antibody–drug conjugate (ADC), α10 antibody conjugated to saporin, on cells xenograft mouse model was studied. We found that strongly expressed both cells, whereas morphologically...
Abstract Curative therapy for medulloblastoma and other pediatric embryonal brain tumors has improved, but the outcome still remains poor current treatment causes long-term complications. Malignant infiltrate healthy tissue and, thus despite resection, cells that have already migrated cause rapid tumor regrowth. Heparan sulfate proteoglycans (HSPG), major components of extracellular matrix (ECM), modulate activities a variety proteins. The enzyme degrades HS, heparanase (HPSE), is an...
Diabetes and hyperhomocysteinemia (HHcy) are two independent risk factors for glomeruloslerosis renal insufficiency. Although PPARgamma agonists such as ciglitazone (CZ) known to modulate diabetic nephropathy, the role of CZ in diabetes-associated HHcy renopathy is incompletely defined. We tested hypothesis that induction by decreases tissue Hcy level; this provides a protective against nephropathy. C57BL/6J mice were administered alloxan create diabetes. Mice grouped 0, 1, 10, 12, 16 wk...
Recent data suggest that insulin resistance can predict cardiovascular disease independently of the other risk factors, such as hypertension, visceral obesity or dyslipidaemia. However, majority available methods to evaluate are complicated operate, expensive, and time consuming. This study was undertaken assess whether serum lipoprotein ratios could in non-diabetic acute coronary syndrome (ACS) patients.Ninety patients with impaired fasting glucose admitted a diagnosis ACS were included...
Nervous system cancers exhibit diverse transcriptional cell states influenced by normal development, injury response, and growth. However, the understanding of these states' regulation pharmacological relevance remains limited. Here we present "single-cell regulatory-driven clustering" (scregclust), a method that reconstructs cellular regulatory programs from extensive collections single-cell RNA sequencing (scRNA-seq) data both tumors developing tissues. The algorithm efficiently divides...
Abstract Increased levels of homocysteine (Hcy), recognized as hyperhomocysteinemia (HHcy), were associated with cardiovascular diseases. There was controversy regarding the detrimental versus cardio protective role inducible nitric oxide synthase (iNOS) in ischemic heart disease. The aim this study to test hypothesis that Hcy generated nitrotyrosine by inducing endothelial synthase, causing endothelial‐myocyte (E‐M) coupling. To differentiate iNOS constitutive (eNOS and nNOS) Hcy‐mediated...