A5084744777- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Sex and Gender in Healthcare
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Female Genital Mutilation/Cutting Issues
- Cancer-related cognitive impairment studies
- Sleep and related disorders
- Health, Environment, Cognitive Aging
- Feminism, Gender, and Sexuality Studies
- Menstrual Health and Disorders
- Neuroendocrine regulation and behavior
- Neurobiology of Language and Bilingualism
- Gender Roles and Identity Studies
- Memory and Neural Mechanisms
- Genital Health and Disease
- Sleep and Wakefulness Research
- Diversity and Career in Medicine
- Neural dynamics and brain function
- Maternal Mental Health During Pregnancy and Postpartum
- Circadian rhythm and melatonin
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
Linköping University
2017-2025
University of Toronto
2016-2025
Baycrest Hospital
2020-2025
Public Health Ontario
2016-2025
Women's College Hospital
2011-2025
Sinai Hospital
2024
Canadian Apheresis Group
2024
Sunnybrook Health Science Centre
2024
Health Sciences North
2022
3M (United States)
2012-2020
In this paper, we argue for Gender as a Sociocultural Variable (GASV) complement to Sex Biological (SABV). (biology) and gender (sociocultural behaviors attitudes) interact influence health disease processes across the lifespan-which is currently playing out in COVID-19 pandemic. This study develops assessment tool-the Stanford Gender-Related Variables Health Research-for use clinical population research, including large-scale surveys involving diverse Western populations. While analyzing...
Magnetic resonance microscopy (MRM) theoretically provides the spatial resolution and signal-to-noise ratio needed to resolve neuritic plaques, neuropathological hallmark of Alzheimer’s disease (AD). Two previously unexplored MR contrast parameters, T2* diffusion, are tested for plaque-specific noise. Autopsy specimens from nondemented controls ( n = 3) patients with AD 5) were used. Three-dimensional diffusion images voxel sizes ranging 3 × 10 −3 mm 5.9 −5 acquired. After imaging, cut...
To clarify the localization of glial protein apolipoprotein E (apoE) in human cortical neurons, we employed specific immunoelectron microscopy using a monoclonal antibody to apoE surgical specimens temporal lobe. The were rapidly fixed after excision from five patients undergoing surgery for medically intractable seizures, and postmortem material was also taken one Alzheimer's disease patient comparison. Strong immunoreactivity observed many astrocytes filling perinuclear cytoplasm distal...
Background: Better understanding and addressing health inequities is a growing global priority.Objective: In this paper, we contribute to the literature examining complex relationships between biological social dimensions in field of inequalities. Specifically, explore potential intersectionality advance current approaches socio-biological entwinements.Design: We provide brief overview combining both factors single study, then investigate contributions an intersectional framework such...
Despite overwhelming evidence that vaccines are safe and effective, there has been a rise in vaccine hesitancy refusal leading to increases the incidence of communicable diseases. Importantly, providing scientific information about benefits not effective counteracting anti-vaccination beliefs. Considering this, better identification those likely be hesitant underlying attitudes predict these beliefs needed develop more strategies combat movements. Focusing on parents as key decision makers...
Mounting evidence supports sex differences in Alzheimer disease (AD) risk. Vascular and hormonal factors may together contribute to AD risk female adults. We investigated whether age at menopause, vascular risk, history of hormone therapy (HT) containing estrogens influence cognition over a 3-year follow-up period. hypothesized that earlier menopause elevated would have synergistic association with lower cognitive scores HT attenuate this preserve cognition.
Normal aging comprises cognitive decline, including deterioration of memory. It has been suggested that this decline in memory is sexually dimorphic because the cessation gonadal steroid secretion occurs during reproductive female, but not male, mammals. We wondered whether neurons brain regions associated with learning and underwent morphological changes were as well steroids influenced these changes. To explore questions, we deprived restored estrogens to young old gonadectomized females...
Abstract We examined the laminar distribution of corticogeniculate neurons in macaque striate cortex labeled by axonal transport following injections retrograde tracers into lateral geniculate nucleus (LGN). Large involving all layers LGN resulted a distinctive bilaminar cells cortical layer 6. One tier was located along 5–6 border and second near bottom layer, leaving middle 6 largely free neurons. Following that were restricted to magnocellular LGN, almost lower tier. In contrast, confined...
Abstract Determining the prevalence and characteristics of individuals susceptible to present with obstructive sleep apnea (OSA) is essential for developing targeted efficient prevention screening strategies. We included 27,210 participants aged ≥45 years old (50.3% women) from Canadian Longitudinal Study on Aging. Using STOP questionnaire combined percentage body fat (%BF), we estimated at high-risk OSA in a sex age-specific manner, tested relation comorbidities, menopause systemic...
Neuritic plaques are the histologic hallmark of Alzheimer's disease (AD); however, extent to which they injurious neurons is unclear. In order investigate this problem, we intracellularly filled human dentate granule cells with Lucifer yellow in a lightly fixed slice preparation and studied relationships between their dendrites neuritic plaques. After counterstaining for drawing cell dendrites, found that there were significant differences morphology control AD cases; from cases generally...
Many of the Somali women who have immigrated to other countries, including Canada, experienced Female Genital Circumcision/ Mutilation/ Cutting (FGC). While there is literature on medical aspects FGC, we were interested in understanding daily life experiences and bodily sensations Somali-Canadian context FGC. Fourteen living Greater Toronto Area interviewed. Interview data analyzed using a phenomenological approach. We found that memory ceremonial cutting was vivid but frequently described...
Emerging evidence suggests that Alzheimer's Disease (AD) risk factors may differentially contribute to disease trajectory in women than men. Determining the effect of AD on brain aging women, compared men, is critical for understanding whether there are sex differences pathways towards cognitively intact but at-risk adults. Brain Age Gap (BAG) a concept used increasingly as measure health; BAG defined difference between predicted age (based structural MRI) and chronological age, with...