A5086254627- Sphingolipid Metabolism and Signaling
- Essential Oils and Antimicrobial Activity
- Neonatal and fetal brain pathology
- Phytochemicals and Antioxidant Activities
- Fetal and Pediatric Neurological Disorders
- Erythrocyte Function and Pathophysiology
- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Ginger and Zingiberaceae research
- Dermatology and Skin Diseases
- Sleep and Wakefulness Research
- Barrier Structure and Function Studies
National University of Singapore
2018-2021
Industrial Technology Institute
2020
University of Colombo
2020
St. Peter's Institute of Higher Education and Research
2014
This study aimed at investigating the anti-inflammatory potential of essential oil from rhizome and leaf Alpinia calcarata Rosc. (ACEO) with focus its topical activity along dominant compounds 1,8-cineole α-terpineol using mouse ear edema model. ACEOs were analyzed by GC-MS. The was determined studying inhibition overproduction proinflammatory mediators-nitric oxide, reactive oxygen species, prostaglandins, cyclooxygenases, cytokines induced lipopolysaccharides in murine macrophages. Topical...
We recently discovered that Mfsd2b, which is the S1P exporter found in blood cells. Here, we report Mfsd2b critical for release of all species both resting and activated platelets. show platelets store cytoplasm. After activation, this pool delivered to plasma membrane, where predominantly localized export. Employing knockout mice reveal contribute a minor amount S1P. Nevertheless, deletion whole body or impairs platelet morphology functions. In particular, significantly reduced thrombus...
Several missense mutations in the orphan transporter FLVCR2 have been reported Fowler syndrome. Affected subjects exhibit signs of severe neurological defects. We identified mouse ortholog Mfsd7c as a gene expressed blood-brain barrier. Here, we report characterizations Mfsd7c-KO mice and compare these to phenotypic findings humans with biallelic mutations. Global KO resulted late-gestation lethality, likely due CNS phenotypes. found that angiogenic growth blood vessels brain embryos was...