A5028919858- Sphingolipid Metabolism and Signaling
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammasome and immune disorders
- Oral Health Pathology and Treatment
- Skin Diseases and Diabetes
- Erythrocyte Function and Pathophysiology
- Barrier Structure and Function Studies
- Fetal and Pediatric Neurological Disorders
- Peripheral Artery Disease Management
- Psoriasis: Treatment and Pathogenesis
- Aortic Thrombus and Embolism
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Head and Neck Cancer Studies
- Cholesterol and Lipid Metabolism
- IL-33, ST2, and ILC Pathways
- Fibroblast Growth Factor Research
- Acute Myocardial Infarction Research
- Eicosanoids and Hypertension Pharmacology
- HIV/AIDS oral health manifestations
- Neonatal and fetal brain pathology
National University of Singapore
2020-2022
Shahjalal University of Science and Technology
2020-2022
Okinawa Institute of Science and Technology Graduate University
2017
Juntendo University
2015-2016
Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders
2013
Institute of Medical Sciences
2004
Abstract CD4 + T-helper cells producing interleukin-17 (IL-17), known as 17 (T H 17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity. Although pathogenic and non-pathogenic T share a common RORγt-dependent transcriptional programme, regulatory mechanisms specific to each of these are mostly unknown. Here we show the AP-1 transcription factor JunB is critical for JunB, which induced by IL-6, essential expression RORγt IL-23 receptor facilitating DNA binding BATF at...
Recent epidemiological evidence suggests that diabetes mellitus (DM) is a risk factor for Alzheimer's disease (AD). One of the pathological hallmarks AD hyperphosphorylated tau protein, which forms neurofibrillary tangles. Oxidative stress and activation inflammatory pathways are features associated with both DM AD. However, brain region specificity AD-related neurodegeneration, mainly occurs in hippocampus while cerebellum relatively unaffected, has not yet been clarified. Therefore, we...
Sphingosine-1-phosphate (S1P) is a potent lipid mediator that exerts its activity via activation of five different G protein–coupled receptors, designated as S1P1–5. This synthesized from the sphingosine precursor by two kinases (SphK1 and 2) must be exported to exert extracellular signaling functions. We recently identified Mfsd2b S1P transporter in hematopoietic system. However, sources for synthesis transport mechanism erythrocytes remain determined. Here, we show efficiently take up...
We recently discovered that Mfsd2b, which is the S1P exporter found in blood cells. Here, we report Mfsd2b critical for release of all species both resting and activated platelets. show platelets store cytoplasm. After activation, this pool delivered to plasma membrane, where predominantly localized export. Employing knockout mice reveal contribute a minor amount S1P. Nevertheless, deletion whole body or impairs platelet morphology functions. In particular, significantly reduced thrombus...
Several missense mutations in the orphan transporter FLVCR2 have been reported Fowler syndrome. Affected subjects exhibit signs of severe neurological defects. We identified mouse ortholog Mfsd7c as a gene expressed blood-brain barrier. Here, we report characterizations Mfsd7c-KO mice and compare these to phenotypic findings humans with biallelic mutations. Global KO resulted late-gestation lethality, likely due CNS phenotypes. found that angiogenic growth blood vessels brain embryos was...
Sphingosine-1-phosphate (S1P) is a potent lipid mediator that secreted by several cell types. We recently showed Mfsd2b an S1P transporter from hematopoietic cells contributes approximately 50% plasma S1P. Here we report the characterization of compound deletion and Spns2, another active primarily in endothelial cells. Global Spns2 (global double knockout [gDKO]) results embryonic lethality beyond day 14.5 (E14.5), with severe hemorrhage accompanied defects tight junction proteins,...
This study explores the impact of betel quid (BQ) chewing on hyperglycaemia among diabetic patients in northeastern Bangladesh. BQ, a prevalent social habit Asia, is often used without awareness its harmful effects. We focus role areca nut, key addictive component influencing hyperglycaemia. Random blood glucose (RBG) tests were conducted 961 patients, alongside lifestyle data, from August 2018 to February 2019 at Sylhet Diabetic Hospital, Statistical analyses, including t-tests, Analysis...
Peripheral arterial disease is a macrovascular complication of type 2 diabetes mellitus. Hyper-homocysteinemia found to be associated with peripheral disease. Homocysteine induced endothelial-cell injury mediated by hydrogen peroxide. Hydrogen peroxide exposes the underlying matrix and smooth muscle cells arteries which, in turn, proliferate promote activation platelets leukocytes. The present study was carried out Department Biochemistry, Dhaka Medical College, from July 2010 June 2011...
Abstract Background Betel quid (BQ) chewing is a common habit and means of social interaction among the northeastern peoples Bangladesh. Though this integrating in their daily life without knowing its toxic effect. Areca nut, which one main components BQ may responsible for addiction. Here, we assess to see how influence hyperglycemia diabetic patients with respect lifestyle. Methodology Random blood sugar (RBS) test was evaluated from total 961 patients. Behavioral data associated lifestyle...
Epidemiological evidence suggests that diabetes mellitus (DM) is a risk factor for Alzheimer’s disease (AD). One of the pathological hallmarks AD hyperphosphorylated tau, which forms neurofibrillary tangles. Oxidative stress and activation inflammatory pathways are features associated with both DM AD. However, brain region specificity AD-related neurodegeneration has not yet been clarified. Here, we examined effects experimental in tau transgenic mice (Tg 601) analyzed regional difference...
Background: Physical exercise has been reported as a preventive measure of Alzheimer's disease, one the neuropathological hallmarks which, neurofibrillary tangles, consist hyperphosphorylated insoluble tau. Long-term treadmill reduced tau hyperphosphorylation: however, it remains unknown whether short-term alters modifications.
Purpose: Alzheimer disease (AD), involved the abnormal metabolism of β-amyloid and tau, is major cause dementia among elderly. Diabetes mellitus (DM) has been identified as a risk factor AD. Two pathological lesions AD, Aβ plaques neurofibrillary tangles, are linked to neuroinflammation lipid peroxidation, also induced by glucose metabolism. Here, we examined effects experimental DM in tau transgenic mice Tg601 (overexpressing wild-type human tau) analyzed brain regional difference occurred due
Summary Sphingosine-1-phosphate (S1P) is a potent lipid mediator that secreted by several cell types to induce signaling. We recently showed Mfsd2b an S1P transporter from hematopoietic cells, which contributes approximately 50% plasma S1P. To further determine the sources of S1P, here, we report characterizations compound deletions and Spns2, another endothelial cells. Global deletion Spns2 (gDKO) resulted in embryonic lethality between E13.5 E14.5 with severe hemorrhage largely...