A5063648700- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Electromagnetic Fields and Biological Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Biochemical effects in animals
- Magnetic and Electromagnetic Effects
- Inflammasome and immune disorders
- Cancer Research and Treatment
- Endoplasmic Reticulum Stress and Disease
- Sphingolipid Metabolism and Signaling
National University of Singapore
2022-2025
National University Health System
2024-2025
Preclinical studies have shown that the blood from female mice exposed weekly to magnetic fields inhibited breast cancer growth. This double-blind randomized controlled trial investigated whether analogous therapy could produce similar anticancer sera human subjects. Twenty-six healthy adult females (ages 30-45) were assigned either a group, receiving twice 1 mT exposures (10 min/session) for 4 weeks, or control who underwent identical sham exposure. Blood evaluated their capacity modulate...
Sphingosine-1-phosphate (S1P) is a potent lipid mediator that secreted by several cell types. We recently showed Mfsd2b an S1P transporter from hematopoietic cells contributes approximately 50% plasma S1P. Here we report the characterization of compound deletion and Spns2, another active primarily in endothelial cells. Global Spns2 (global double knockout [gDKO]) results embryonic lethality beyond day 14.5 (E14.5), with severe hemorrhage accompanied defects tight junction proteins,...
: Doxorubicin (DOX) is commonly used as a chemotherapeutic agent for the treatment of breast cancer. Nonetheless, its systemic delivery via intravenous injection and toxicity towards healthy tissues result in broad range detrimental side effects. Breast cancer severity was previously shown to be correlated with TRPC1 channel expression that conferred upon it enhanced vulnerability pulsed electromagnetic field (PEMF) therapy. PEMF therapy also enhance cell DOX
Abstract MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small molecules. Two isoforms have been identified and they are reported be heme exporters play a crucial role in maintaining cytosolic mitochondrial levels, respectively. Mutations (also known as FLVCR1) linked retinitis pigmentosa, posterior column ataxia, hereditary sensory autonomic neuropathy. Although functions detoxification by exporting excess from erythroid cells, it is ubiquitously expressed...