A5019292959- Electromagnetic Fields and Biological Effects
- Magnetic and Electromagnetic Effects
- Spaceflight effects on biology
- Advanced X-ray and CT Imaging
- Ion Channels and Receptors
- Genetics, Aging, and Longevity in Model Organisms
- Planarian Biology and Electrostimulation
- Neonatal Respiratory Health Research
- Venous Thromboembolism Diagnosis and Management
- Radiology practices and education
- Radiation Dose and Imaging
- S100 Proteins and Annexins
- Diet and metabolism studies
- Microbial Inactivation Methods
- Muscle Physiology and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutrition, Genetics, and Disease
National University of Singapore
2020-2024
National University Health System
2022-2024
University of California San Francisco Medical Center
2020
University of California, San Francisco
2007
We show that both supplemental and ambient magnetic fields modulate myogenesis. A lone 10 min exposure of myoblasts to 1.5 mT amplitude pulsed (PEMFs) accentuated in vitro myogenesis by stimulating transient receptor potential (TRP)‐C1‐mediated calcium entry downstream nuclear factor activated T cells (NFAT)‐transcriptional P300/CBP‐associated (PCAF)‐epigenetic cascades, whereas depriving slowed myogenesis, reduced TRPC1 expression, silenced NFAT‐transcriptional PCAF‐epigenetic cascades. The...
Pulsing electromagnetic fields (PEMFs) have been shown to promote in vitro and vivo myogeneses via mitohormetic survival adaptations of which secretome activation is a key component. A single 10-min exposure donor myoblast cultures 1.5 mT amplitude PEMFs produced conditioned media (pCM) capable enhancing the myogenesis recipient similar degree as direct magnetic exposure. Downwardly-directed greater responses than upwardly-directed adherent fluid-suspended myoblasts. The suspension paradigm...
Briefly (10 min) exposing C2C12 myotubes to low amplitude (1.5 mT) pulsed electromagnetic fields (PEMFs) generated a conditioned media (pCM) that was capable of mitigating breast cancer cell growth, migration, and invasiveness in vitro, whereas the harvested from unexposed myotubes, representing constitutively released secretome (cCM), less effective. Administering pCM microtumors engrafted onto chorioallantoic membrane chicken eggs reduced tumor volume vascularity. Blood serum collected...
Chemotherapy is the mainstream treatment modality for invasive breast cancer. Unfortunately, chemotherapy-associated adverse events can result in early termination of treatment. Paradoxical effects chemotherapy are also sometimes observed, whereby prolonged exposure to high doses chemotherapeutic agents results malignant states resistant chemotherapy. In this study, potential synergism between doxorubicin (DOX) and pulsed electromagnetic field (PEMF) therapy was investigated in: 1) MCF-7...
Exercise modulates metabolism and the gut microbiome. Brief exposure to low mT-range pulsing electromagnetic fields (PEMFs) was previously shown accentuate in vitro myogenesis mitochondriogenesis by activating a calcium-mitochondrial axis upstream of PGC-1α transcriptional upregulation, recapitulating genetic response implicated exercise-induced metabolic adaptations. We compared effects analogous PEMF (1.5 mT, 10 min/week), with without exercise, on systemic microbiome four groups mice: (a)...
Conventional root canal treatment replaces the infected pulp with defined materials. Alternative cell-based tissue engineering strategies aim to regenerate a fully functional within canal. Despite recent advances in this area, however, regeneration of an innervated remains major challenge field. Both graphene (2DG) and pulsed electromagnetic fields (PEMFs) independently have been shown promote diverse cellular developmental programs. The present study showed that 2DG promoted neurogenic...
: Doxorubicin (DOX) is commonly used as a chemotherapeutic agent for the treatment of breast cancer. Nonetheless, its systemic delivery via intravenous injection and toxicity towards healthy tissues result in broad range detrimental side effects. Breast cancer severity was previously shown to be correlated with TRPC1 channel expression that conferred upon it enhanced vulnerability pulsed electromagnetic field (PEMF) therapy. PEMF therapy also enhance cell DOX
Abstract Background Chemotherapy is the mainstream treatment modality for invasive breast cancer. Nonetheless, chemotherapy-associated adverse events can result in a patient terminating treatment. We show that transient receptor potential channel 1 (TRPC1) expression level predicts cancer sensitivity to doxorubicin (DOX) and pulsed electromagnetic field (PEMF) therapies. Methods The effects of PEMFs were examined with respect to: ) growth MCF-7 cells vitro ; 2 tumors implanted into chicken...
In the widening scope of techniques and imaging advancements, there's a new responsibility imposed on clinicians to ensure patient safety.
Li, Fanny; De Leon, Noelle; Schell-Chaple, Hildy; Zhao, Lucia; Kolli, K. Pallav; Fong, Charlene Author Information