A5090131017- Integrated Circuits and Semiconductor Failure Analysis
- VLSI and Analog Circuit Testing
- Non-Invasive Vital Sign Monitoring
- Advanced Sensor and Energy Harvesting Materials
- Wireless Body Area Networks
- Sphingolipid Metabolism and Signaling
- Semiconductor materials and devices
- Antenna Design and Analysis
- Energy Harvesting in Wireless Networks
- Advancements in Semiconductor Devices and Circuit Design
- Neuroscience and Neuropharmacology Research
- Indoor and Outdoor Localization Technologies
- Biomedical Research and Pathophysiology
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Geotechnical Engineering and Soil Stabilization
- Bluetooth and Wireless Communication Technologies
- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobin structure and function
- Neonatal Health and Biochemistry
- Interactive and Immersive Displays
- Industrial Vision Systems and Defect Detection
- Advanced Surface Polishing Techniques
- Lysosomal Storage Disorders Research
- Electrostatic Discharge in Electronics
National University of Singapore
2020-2024
Yong In University
2024
University of Utah
2023
Ho Chi Minh City University of Transport
2020-2021
Texas Instruments (United States)
2002-2013
Boeing (United States)
2005
An integrated smart microfluidic dressing with a multibiomarker immunosensor can provide in situ wound status profiling on site.
Implanted bioelectronic devices can form distributed networks capable of sensing health conditions and delivering therapy throughout the body. Current clinically-used approaches for wireless communication, however, do not support direct networking between implants because signal losses from absorption reflection by As a result, existing examples such rely on an external relay device that needs to be periodically recharged constitutes single point failure. Here, we demonstrate...
Accumulation of sphingolipids, especially sphingosines, in the lysosomes is a key driver several lysosomal storage diseases. The transport mechanism for sphingolipids from lysosome remains unclear. Here, we identified SPNS1, which shares highest homology to SPNS2 - sphingosine-1-phosphate (S1P) transporter, functions as transporter lysolipids lysosome. We generated Spns1 knockout cells and mice employed lipidomic metabolomic approaches reveal SPNS1 ligand identity. Global caused embryonic...
Ambient sensors can continuously and unobtrusively monitor a person’s health well-being in everyday settings. Among various sensing modalities, wireless radio-frequency offer exceptional sensitivity, immunity to lighting conditions, privacy advantages. However, existing are susceptible environmental interference unable capture detailed information from multiple body sites. Here, we present technique transform passive surfaces the environment into highly sensitive localized using...
Abstract Mutations in the orphan transporter MFSD7c (also known as Flvcr2 ), are linked to Fowler syndrome. Here, we used Mfsd7c knockout ( –/– ) mice and cell-based assays reveal that is a choline at blood–brain barrier (BBB). We performed comprehensive metabolomics analysis detected differential changes of metabolites brains livers embryos. Particularly, found choline-related were altered but not Thus, hypothesized regulates level brain. Indeed, expression human cells significantly...
Abstract Wireless and battery-free radio-frequency (RF) sensors can be used to create physical spaces that ambiently sense respond human activities. Making such ultra-flexible transparent is important preserve the aesthetics of living environments, accommodate daily activities, functionally integrate with objects. However, existing RF are unable simultaneously achieve high transparency, flexibility, electrical conductivity required for remote room-scale operation. Here, we report 4.5 µm tag...
Layered structures are widely used in optics to control wave reflection and propagation at interfaces but their thickness relative the wavelength hinders application radio-frequency regime. Here, we design experimentally demonstrate cascaded metasurfaces with deeply subwavelength that provide both antireflection wavefront manipulation. We describe systematic synthesis of metasurface layers from a prescribed scattering response designs capable providing near-perfect microwave transmission...
Radio frequency technologies are capable of remotely sensing human vital signs for broad applications in healthcare. However, their use during daily life is hindered by challenges such as environmental interference, low sensitivity, and nonideal form factors. Here, we report a radio sensor made from conductive textile that provides sensitive noncontact monitoring signs. The (13 cm2 size) comprises radial pattern grooves support spoof localized surface plasmon (LSP) modes ground plane with...
The ability to transmit wireless signals into the body is important for medical communication, sensing, and powering technologies. However, efficiency of signal transmission limited by large reflection encountered at interface between air biological tissue. Here, we demonstrate an approach overcome this using cascaded metasurfaces (MSs) with deeply subwavelength thickness transform wave impedance air–tissue interface. We develop a procedure systematically synthesize these MSs multilayer...
Abstract Aims Circulating levels of sphingosine 1-phosphate (S1P), an HDL-associated ligand for the endothelial cell (EC) protective S1P receptor-1 (S1PR1), are reduced in disease states associated with dysfunction. Yet, as S1PR1 has high affinity and can be activated by ligand-independent mechanisms EC autonomous production, it is unclear if relative reductions circulating cause It also how insufficiency, whether induced deficiency or S1PR1-directed immunosuppressive therapy, affects...
Abstract Mutations of MFSD7c (also known as Flvcr2 ), which is an orphan transporter, are linked to Fowler syndrome 1, 2 . Here, we use Mfsd7c knockout mice and cell-based assays reveal that a choline transporter at the blood-brain barrier (BBB). We performed comprehensive metabolomics detected differential changes metabolites in brains livers ( −/− ) embryos. Particularly, found choline-related were altered but not Thus, hypothesized regulates levels brain. Indeed, expression human cells...
Vital sign monitoring is important for determining the health status and well-being of an individual. Despite their high level accuracy, clinical sensing methods vital signs, such as heart or respiration signals, often require direct skin contact use wires, making them restrictive inconvenient. In contrast, alternative approaches using wireless means can be comfortable users are suitable long-term, continuous scenarios. Recent advances in physiological Doppler radars present great potential...
DNA-Encoded Libraries (DEL) are combinatorial small molecule libraries that offer an efficient way to characterize diverse chemical spaces. Selection experiments using DELs pivotal drug discovery efforts, enabling high-throughput screens for hit finding. However, limited availability of public DEL datasets hinders the advancement computational techniques designed process such data. To bridge this gap, we present KinDEL, one first large, publicly available on two kinases: Mitogen-Activated...
Continuous in-vehicle physiological monitoring can improve safety through early detection of driver fatigue and drowsiness. However, developing a system capable effective robust in practical driving scenarios is challenging due to the noisy vehicular environment which sensor exposed engine vibrations, unpredictable road conditions random body motions. In this work, we introduce seatbelt-integrated metamaterial for unobtrusive continuous respiration heartbeat monitoring. The fabricated by...
Abstract MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small molecules. Two isoforms have been identified and they are reported be heme exporters play a crucial role in maintaining cytosolic mitochondrial levels, respectively. Mutations (also known as FLVCR1) linked retinitis pigmentosa, posterior column ataxia, hereditary sensory autonomic neuropathy. Although functions detoxification by exporting excess from erythroid cells, it is ubiquitously expressed...
Currently, the construction technology on soft ground reinforcement is very developed, including of constructing soil-cement piles for soil which technically and economically effective widely used.Another using fly ash waste from thermal power plants to make ash-soil reinforcement, not only takes advantage local materials but also reduces environmental pollution operating plants.This paper introduces some research results content pile diameter when reinforcing ground.The authors modeled...
This paper addresses how an observed secondary defect could be induced during the failure analysis and caused original mode to recovered. Two cases studies will presented with systematic approach of Failure successful attempt finding while extrapolating data at time recovery. Understanding working circuitry in question is necessary trace failure.
Wireless networking of bioelectronic devices holds immense potential for physiological sensing and modulation. However, the human body presents formidable challenges to achieving efficient wireless communication due signal obstruction, absorption, reflection. In this paper, we propose a textile-integrated side-fed phased surface overcome these enable between wearable implantable devices. The planar design with configuration allows seamless integration textile spoof plasmon (SSP) networks on...
Abstract Accumulation of sphingolipids, especially sphingosines, in the lysosomes is attributed to pathogenesis several lysosomal storage diseases. In search for a protein that mediates release we identified SPNS1 which shares highest homology SPNS2, sphingosine-1-phosphate (S1P) transporter. We generated knockout cells and mice Spns1 employed lipidomics metabolomics identify ligands. found knockouts resulted accumulation including sphingosines embryonic brains cell lines. These results...
This paper describes a configurable passive voltage contrast (PVC) checker for fault identification. The uses an on-line trace technique to query connectivity of design layout features downward, and color coded the checked according pre-defined terminations. was used identification on scan based design. emulated PVC behavior expedites comparison scanning electron microscope (SEM) images shortening time localization.
In recent years, owing to advances in technology, excavation pits have shown increased improvements.Taking advantage of advanced solutions combined with traditional ones has brought about considerable advantages for construction contractors and saves on expenses carry out projects.Owing their ability analyze geotechnical problems, several calculation simulation software, such as Plaxis, Bentley, along many others, grown popularity.Among them, Midas is one which a set developed by the MIDAS...