A5101488384- Gestational Diabetes Research and Management
- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Toxin Mechanisms and Immunotoxins
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Dementia and Cognitive Impairment Research
- Iron Metabolism and Disorders
- PARP inhibition in cancer therapy
- Computational Drug Discovery Methods
- Adolescent and Pediatric Healthcare
- Inflammatory Bowel Disease
- Acute Myeloid Leukemia Research
- Folate and B Vitamins Research
- T-cell and B-cell Immunology
Stanford University
2018-2020
University of Missouri–Kansas City
2020
Children's Mercy Hospital
2020
University of Michigan
2004
Autoantibodies to nuclear components of cells (antinuclear antibodies, ANA), including DNA (a-DNA), are widely used in the diagnosis and subtyping certain autoimmune diseases, systemic lupus erythematosus (SLE). Despite clinical use over decades, precise, reproducible measurement a-DNA titers remains difficult, likely due substantial sequence length heterogeneity purified from natural sources. We designed tested a panel synthetic nucleic acid molecules composed native deoxyribonucleotide...
Objective The incidence of inflammatory bowel disease (IBD) in juvenile idiopathic arthritis (JIA) is higher than the general pediatric population. However, reports IBD systemic JIA (sJIA) subtype are limited. We sought to characterize sJIA patients diagnosed with and identify potential contributing risk factors. Methods Using an internationally distributed survey, we identified 16 who were subsequently (sJIA-IBD cohort). Five hundred twenty-two without from CARRA Legacy Registry served as...
DNA-Encoded Libraries (DEL) are combinatorial small molecule libraries that offer an efficient way to characterize diverse chemical spaces. Selection experiments using DELs pivotal drug discovery efforts, enabling high-throughput screens for hit finding. However, limited availability of public DEL datasets hinders the advancement computational techniques designed process such data. To bridge this gap, we present KinDEL, one first large, publicly available on two kinases: Mitogen-Activated...
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