Background and Objectives: Acute pancreatitis (AP) is an inflammatory disease where there autodigestion of the pancreas by prematurely activated enzymes which may lead to a systemic response. The aim our study was investigate levels circulating serum leukotriene B4 (LTB4), lipoxin A4 (LXA4), resolvin D1 (RvD1) in due gallstones etiologic investigation AP. Materials Methods: A total 147 patients with AP (n: 49), AC combined + 49) will be included study. Healthy volunteers as control group....

Background: Medical history, ECG findings and cardiac markers are used in the diagnosis of myocardial infarction (MI). Biomarkers especially for MI include high-sensitivity troponins (hsTns), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), myoglobin, myosin-binding protein C new biomarkers. This study evaluated levels serum thrombomodulin (TM), heart-type fatty-acid-binding (H-FABP), pentraxin-3 (PTX-3) galectin-3 (Gal-3) to determine their utility distinguishing between...

Purpose Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective this study was to determine 8-hydroxydeoxyguanosine (8-OHdG) level a marker oxidative DNA damage, glutathione peroxidase (G-Px), superoxide dismutase (SOD) activities antioxidant activity, in sera from women with breast Methods Forty-nine patients malign tumor were included the study. Blood samples collected before surgical operation. Serum 8-OHdG measured...

Purpose Myocardial damage mediated by oxidative stress during acute myocardial infarction (MI) has been suggested as an obstructive factor on recovery after MI. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker for DNA damage; superoxide dismutase (SOD) and glutathione peroxidase (G-Px) are major antioxidant enzymes. We determined changes in the plasma level of 8-OHdG activities SOD G-Px patients with MI examined relations between those other cardiac markers. Methods Blood samples were taken at...

Insulin resistance is one of the feature obesity. Fetuin A inhibitor insulin receptor which belongs family tyrosine kinase. It has been observed that fetuin-null mice are resistant to diet-induced obesity and they exhibit increased sensitivity. Increased production reactive oxygen species suggested be associated with resistance. Attacks DNA results in base oxidation. Among oxidized bases, 8-hydroxydeoxyguanosine predominant lesion pro-mutagenic potential. In present study; measurement serum...

Hasbal C, Aksu BY, Himmetoglu S, Dincer Y, Koc EE, Hatipoglu Akcay T. DNA damage and glutathione level in children with asthma bronchiale: Effect of antiasthmatic therapy.Pediatr Allergy Immunol 2010: 21: e674–e678.© 2009 John Wiley & Sons A/S When the production reactive oxygen species (ROS) exceeds capacity antioxidant defences, a condition known as oxidative stress occurs it has been implicated many pathological conditions including asthma. Interaction ROS may result mutagenic base...

We conducted a clinical trial to examine the effect of ω-3 fatty acids in patients with cardiac syndrome X (CSX). aimed evaluate potential impact on endothelial function, oxidative stress, and symptom relief CSX.Eighteen CSX were enrolled according double-blind, randomized, placebo-controlled design. Patients randomized (1440 mg/day, n=8) or placebo (n=10) for 4 months. assessed plasma levels malondialdehyde (MDA), endothelium-dependent vasodilatation [flow-mediated dilatation (FMD)],...

Purpose: To examine apoptotic markers in serum of subjects with diabetes and impaired glucose tolerance (IGT). Serum levels p53 cytochrome c, regulator molecules for apoptosis, were measured type 2 diabetes, IGT healthy controls. Methods: Forty one 27 volunteers included the study. level c competitive ELISA. Results: lower group (085±0.39 U/ml) than controls (1.09±0.49 (P < 0.05) (0.98±0.37 0.05). There was no significant difference between Also, there among groups. In mildly correlated...

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)

ABSTRACT Introduction: Although potential relationships with genetic variants of MLCK2, AMPD1 and COL5A1 have been detected in molecular studies evaluating sports performance from the perspective, there are limited data terms muscle endurance physical fitness. Materials Methods: This study aimed to evaluate these lower limb fitness thirty-three soccer players. Genotypes were determined by High Resolution Melting (HRM) analysis qPCR after genomic DNA was isolated buccal swab samples...

Objective: The aim of the present study was to investigate new markers for metabolic syndrome. Fetuin-A is a physiological inhibitor insulin receptor and associated with resistance. Adipocyte fatty acid-binding protein regulates cellular lipid metabolism by carrying free acids various intracellular compartments. Recently antioxidant insulinotropic roles adipocyte were determined. 8-hydroxydeoxyguanosine as marker oxidative DNA damage. In study, plasma levels fetuin A, determined in cases...

Cíle: Podle dosavadních studií byla ateroskleróza považována za chronické zánětlivé onemocnění, přičemž složky imunitního systému se podílejí na aterogenezi. Systém receptoru CD40 a ligandu reguluje řadu fází hormonální buněčné imunitní odpovědi. Zvláště solubilní ligand (sCD40) uvolňuje z aktivovaných krevních destiček. Destičky nejen rozvoji trombózy, ale i tvorbě aterosklerotických lézí procesu restenózy. Cílem naší studie bylo zjistit, zda existuje vztah mezi hodnotami sCD40...

Abstract Background Altered signalling of human epidermal growth factor receptor-2 (HER-2/neu), insulin-like 1 (IGF-1) and (EGF) have been shown to play important role in tumor development progression various cancers. Their serum levels may be reliable indicator for diagnosis cancer. Objective To examine the soluble HER-2/neu (sHER-2/neu), IGF1 EGF patients with urinary bladder cancer (UBC). Material methods Serum sHER-2/neu, were measured by enzyme-linked immune assay newly diagnosed,...