A5010487135- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- Nanoparticles: synthesis and applications
- Vitamin C and Antioxidants Research
- Tuberculosis Research and Epidemiology
- Nanoparticle-Based Drug Delivery
- Cassava research and cyanide
- Radiation Therapy and Dosimetry
- Graphene and Nanomaterials Applications
- COVID-19 Clinical Research Studies
- Head and Neck Cancer Studies
- Carbon Nanotubes in Composites
- Advanced Radiotherapy Techniques
- Bioinformatics and Genomic Networks
- Enzyme function and inhibition
- Cell death mechanisms and regulation
- Peroxisome Proliferator-Activated Receptors
- Phytochemical and Pharmacological Studies
- Aluminum toxicity and tolerance in plants and animals
- vaccines and immunoinformatics approaches
- Pharmacological Effects of Medicinal Plants
- Hemoglobin structure and function
- Food Science and Nutritional Studies
- Chemical Reactions and Mechanisms
Hamedan University of Medical Sciences
2021-2024
Ahvaz Jundishapur University of Medical Sciences
2014-2019
Islamic Azad University, Shoushtar Branch
2012
University of Tehran
2010
Metals can cause male infertility through affection of spermatogenesis and sperm quality. Strong evidences confirm that in metal-exposed humans is mediated via various mechanisms such as production reactive oxygen species (ROS). Flavonoids have antioxidant metal chelating properties which make them suitable candidates for neutralizing adverse effects metals on semen In the current study, we evaluated five types flavonoids (rutin, naringin, kaempferol, quercetin, catechin) recovery motility...
Postprandial hyperglycemia plays an important role in the development of type 2 diabetes. Inhibition alpha-amylase was led to a delay breaks down starch and glycogen prevented rapid rise blood sugar. Alpha-amylase isolated by gel filtration chromatography Sephadex G-75 from bovine pancreas. Then, total methanolic extracts plants were prepared IC 50 values on obtained compared with acarbose . The polyphenolic content antioxidant capacity determined Folin-Ciocalteu test DPPH test,...
Abstract BACKGROUND Cellulose as a renewable biomaterial has forced attention on the use of cellulose‐hydrolyzing enzymes for industrial bioconversion lignocellulosic materials to glucose. This paper reports immobilization cross‐linked cellulase aggregates ( CLEA ) amine‐functionalized Fe 3 O 4 @silica core‐shell magnetic nanoparticles MNPs ). RESULTS The optimum pH cocktail upon (cellulase CLEA–MNP shifted little acidic side whereas temperature did not change significantly. behavior CMCase...
Expression of human epidermal growth factor receptor type 2 (HER2) in head and neck squamous cell carcinoma (HNSCC) line HN5 can be employed with great opportunities success for specific targeting anti-cancer chemotherapeutic agents.In the current study, HER2-specific affibody molecule, ZHER2:342 (an engineered protein affinity HER2 receptors) was selected conjugation to idarubicin anti-neoplastic antibiotic).ZHER2:342 gene one added cysteine code at its 5' end synthesized de novo then...
Abstract Head and neck squamous cell carcinoma (HNSCC) are between most common cancer worldwide. Most HNSCC tumors characterized by higher expression of human epidermal growth factor receptor 2 (HER2) that is related to resistance chemotherapy radiotherapy. Accordingly, HER2 has been proposed as a fair target for specific chemotherapy. Lapatinib potent inhibitor the EGFR family were treatment HER2-positive cases. In current study, at first step we used crystal structure HER1-lapatinib...
Reproductive toxicity of carboxyl-functionalised carbon nanotubes (CNT-COOH), as the most commonly used form water-soluble CNTs, is not clearly studied. The aim this study was to investigate in vitro carboxylated single-walled and multi-walled CNTs (SWCNT-COOH MWCNT-COOH) against human spermatozoa. Sperm cells from healthy donors were incubated with 0.1-100 μg/ml SWCNT-COOH or MWCNT-COOH at 37°C for up 5 hr. Viability sperm assessed using MTT test, motility evaluated following World Health...
Malfunction or overexpression of ErbB receptors (epidermal growth factor receptors) is associated with occurrence and severity several types cancer. Initiation signal cascades by ErbB2 (also known as human epidermal receptor 2/neu) in breast cancer has been blocked monoclonal antibodies such Trastuzumab (Herceptin), which interact the extracellular domain 2. Due to some disadvantages antibodies, a new approach blocking 2 dimerization activation designing peptidomimetic ligands based on...
Carbonic anhydrase owing to its potential as an industrial biocatalyst for carbon dioxide sequestration from flue gas has attracted considerable attention in solving global warming problems. A large body of research been conducted increase the thermal stability carbonic different sources against harsh operational conditions CO2 capture systems. In contrast cost-intensive protein engineering methods, solvation with aqueous-organic binary mixtures offers a convenient and economical alternative...
Head and neck squamous cell carcinoma (HNSCC) with a high mortality rate is among the most common types of cancer in world. Human epidermal growth factor receptor 2 (HER2) expressed higher than normal level HNSCC tumors, making them resistant to chemotherapy radiotherapy. Therefore, HER2 has been introduced as suitable target for anticancer drugs. The aim this study examine efficacy treatment protocol involving targeted delivery idarubicin encapsulated trastuzumab-decorated liposomes cells.
Background and purpose: Carbon nanotubes (CNTs) are a significant discovery in nanotechnology, with widespread applications modern technology. However, there concerns about their potential toxicity, particularly skin cells. This study aimed to investigate the mechanisms by which CNTs induced cytotoxicity apoptosis mouse fibroblasts. Experimental approach: The mice fibroblasts were isolated exposed two types of at various concentrations then analyzed for changes viability, reactive oxygen...
Overexpression of human epidermal growth factor receptor 2 (HER2) causes cell transformation and development various types malignancies. Idarubicin is an effective anti-neoplastic drug but its specific delivery to the targeted cells still a great challenge. Affibody as cost-effective peptide molecule with low molecular weight has high affinity for HER2 receptors. Breast ovarian cancers wide speared malignancies are associated expression HER2. In current study, we assessed cytotoxic effects...
Targeting of cancerous cells with a high level human epidermal growth factor receptor 2 (HER2) expressions by drug immunoconjugates is new approach for specific delivery chemotherapeutic agents. Our previous work indicated that idarubicin-ZHER2 affibody conjugate has great potential the treatment HER2-overexpressing malignant cell lines but possible induced immune response against constructed was not addressed. In current study, possibility induction humoral and cellular responses in BALB/c...
Lactate dehydrogenase C (LDHC) as the most abundant isoform of lactate in testis and spermatozoa, has a critical role energy metabolism germ cells. Also, LDHC gene is expressed aberrantly with high prevalence various kinds malignancies. So, promising target protein for development contraceptive anti-cancer drugs. In current study, inhibitory effects nicotine cotinine on human were investigated. Partially purified was extracted from healthy spermatozoa treated concentrations at range...