A5025721466- Cutaneous Melanoma Detection and Management
- Optical Coherence Tomography Applications
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Dermatologic Treatments and Research
- Cell Image Analysis Techniques
- melanin and skin pigmentation
- Skin Protection and Aging
- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Cancer and Skin Lesions
- Cellular Mechanics and Interactions
- Genetic and rare skin diseases.
- Atherosclerosis and Cardiovascular Diseases
- Blood donation and transfusion practices
- Patient Safety and Medication Errors
- Psoriasis: Treatment and Pathogenesis
- Migration, Racism, and Human Rights
- Herpesvirus Infections and Treatments
- Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Advancements in Transdermal Drug Delivery
- Infectious Diseases and Mycology
- Food Allergy and Anaphylaxis Research
- Facial Rejuvenation and Surgery Techniques
University of Modena and Reggio Emilia
2015-2024
Universidade Federal do Rio de Janeiro
2022-2024
Universidade Federal do Estado do Rio de Janeiro
2019-2020
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2017
The clinical recognition of lentigo maligna (LM) and LM melanoma can be very challenging due to the overlapping features it shares with other pigmented macules skin. Noninvasive diagnostic techniques assist in differential diagnosis.To identify reflectance confocal microscopy (RCM) indicators for through identification vivo microscopic substrates main dermoscopic seen flat lesions face.Retrospective analysis 60 (LM, invasive melanoma, solar lentigo/flat seborrhoeic keratosis, lichen...
Abstract Background The sub‐optimal diagnostic accuracy for melanoma leads to excise a high number of benign lesions, with consequent costs. Reflectance confocal microscopy ( RCM ) improves specificity, thus possibly inducing reduction in unnecessary excisions and related Objective To estimate the influence on lesions needed NNE melanoma, term clinical outcomes costs per patient. Patients Methods Skin neoplasms excised by dermatology public service Province Modena were retrieved form...
Mohs Micrographic Surgery (MMS) is the preferred therapeutic treatment for high-risk basal cell carcinoma (BCC). Optical Coherence Tomography (OCT) a non-invasive imaging technique that enables diagnosis of BCC. We thought to determine margins BCCs with OCT, prior MMS, reduce number surgical steps.Different permanent markers were tested on skin regarding line width, resistance against disinfection and brightness in OCT image. The visible tumor defined by dermoscopy, adding safety margin 2 mm...
Abstract Background Acne vulgaris is a disease of the pilosebaceous unit, characterized by hyper‐keratinization process, comedos formation and inflammatory reactions. Objective The definition morphology vascularization acne lesions means dynamic optical coherence tomography (D‐ OCT ), to non‐invasively define alterations occurring during development patient therapeutic management. Methods A set standardized clinical pictures D‐ images were acquired from 114 31 volunteers, presenting mild...
Abstract Background Dynamic optical coherence tomography (D‐OCT) has recently been introduced in dermatology. In contrast to ‘Standard’ OCT imaging, which exclusively relies on the morphological analysis of tissue, D‐OCT allows vivo visualization blood flow. Preliminary data showed differences vascularization nevus melanoma transition, suggesting that this technology may help differentiate between benign and malignant lesions. Objective Several factors influence quality imaging. Therefore,...
Lentigo maligna may be challenging to clear surgically.To evaluate feasibility of using superficial skin cuts as RCM imaging anchors for attaining negative surgical margins in lentigo maligna.Included patients presented with near cosmetically sensitive facial structures. We evaluated, hand-held-RCM, microscopic clearance melanoma beyond its dermoscopically detected edges. Evaluated were annotated shallow cuts. If a margin was positive at 'first-step' evaluation, we sequentially advanced the...
Abstract The subtype of basal cell carcinoma ( BCC ) influences the choice treatment. Optical coherence tomography OCT is a non‐invasive imaging tool, and recent development an angiographic version has extended application to image cutaneous microvasculature (so‐called dynamic , D‐ ). This study explores 's ability differentiate common subtypes by microvascular structural imaging. Eighty‐one patients with 98 lesions, consisting three subtypes: 27 superficial sBCC ), 55 nodular nBCC 16...
Abstract Background Malignant melanoma is an aggressive skin cancer, which can lead to metastasis development. Vascularization enhancement fundamental for tumor growth, worsening the prognosis. Dynamic optical coherence tomography (D‐ OCT ) enables in vivo evaluation of vascular patterns lesions. Objective In vessel morphology by means D‐ and correlation with Breslow index. Methods Retrospective analysis histologically proven melanomas, evaluated at three different depths (150, 300 500 μm),...
Abstract Pigmented facial macules are common on sun damage skin. The diagnosis of early stage lentigo maligna ( LM ) and melanoma LMM is challenging. Reflectance confocal microscopy RCM has been proven to increase diagnostic accuracy lesions. A total 154 pigmented macules, retrospectively collected, were evaluated for the presence already‐described features new parameters depicting aspects follicle. Melanocytic nests, roundish pagetoid cells, follicular infiltration, bulgings from follicles...
Background Reflectance confocal microscopy (RCM) is an imaging device that permits non-invasive visualization of cellular morphology and has been shown to improve diagnostic accuracy dermoscopically equivocal cutaneous lesions. The application double reader concordance evaluation dermoscopy-RCM image sets in retrospective settings its potential telemedicine not tested a large study population. Objective To sensitivity RCM diagnosis using approach; reduce mismanagement lesions consultation...
Studies on the role of antibodies produced after infection with human papillomavirus 18 (HPV-18) and subsequent protection from HPV-18 have been conflicting, mainly due to inadequate sample size.
Abstract Background The melanocortin 1 receptor (MC1R) gene is one of the major determinants skin pigmentation. It a highly polymorphic and some its polymorphisms have been related to specific phenotypes, increased risk cancers photoageing. Currently, contribution changes in dermal features photo‐exposed unknown. Objective main objective this study evaluate potential correlation between MC1R status healthy characteristics. Materials methods Skin facial were estimated by evaluation with...
Objectives and background: Nowadays, several approaches for skin rejuvenation of the lower eyelid are available. We present a new technique resurfacing with ablation periorbital (RAP) performed in single session. Methods: This is retrospective study involving 20 patients showing elastosis or without evidence nasojugal fold atrophic dyschromic needing combined approach transconjuntival blepharoplasty fat bag removal. RAP assessed terms efficacy, safety, 3D evaluation results at 6 months'...
Atypical basal cell carcinoma (BCC), characterized by equivocal dermoscopic features typical of malignant melanoma (MM), can be difficult to diagnose. Reflectance confocal microscopy (RCM) enables in vivo imaging at nearly histological resolution.To evaluate with RCM atypical melanocytic lesions identified dermoscopy, according common criteria for the differential diagnosis BCC, and identify representative parameters superficial (sBCCs) nonsuperficial (nsBCCs) carcinomas (BCCs).A...
Abstract Background Dynamic optical coherence tomography (D‐OCT) allows in vivo visualization of blood vessels the skin and malignant tumours. Vessel patterns melanoma may be associated with tumour stage. Objective The aim this study was to describe vessel melanomas correlate them Methods One hundred fifty‐nine were assessed a multicentre study. Every imaged using D‐OCT prior surgery histologic evaluation. data such as thickness ulceration well staging at primary diagnosis follow‐up least 40...
Along with the rising melanoma incidence in recent decades and bad prognoses resulting from late diagnoses, distinguishing between benign malignant melanocytic lesions has become essential. Unclear cases may require aid of non-invasive imaging to reduce unnecessary biopsies. This multicentric, case-control study evaluated potential dynamic optical coherence tomography (D-OCT) identify microvascular features nevi. A total 167 nevi, including dysplastic ones, on 130 participants all ages sexes...
Atopic dermatitis (AD) is a result of complex genetic, epigenetic, environmental, and immunological interactions with an overlapping epidermal barrier defect. The study evaluates the efficacy tolerability topical Vitamin B12-barrier cream (MB12) compared standard glycerol-petrolatum-based emollient (GPC) used three times day for mild AD. was conducted as on one hemi-body randomized, controlled, single-blind, intra-patient left-to-right comparative trial by patients clinical diagnosis AD...
Abstract Background Reflectance confocal microscopy (RCM) has been used for the evaluation of several inflammatory skin conditions, including discoid lupus erythematosus (DLE), and correlated with conventional histopathology (HP). However, RCM is not being widely in trichology. Few reports just preliminary data suggest use as a complementary tool alopecias. Objectives To correlate major features scalp DLE trichoscopy HP findings biopsy specimens obtained from same lesions. Methods This an...