A5072014178- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Diverticular Disease and Complications
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Global Cancer Incidence and Screening
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Chronic Myeloid Leukemia Treatments
- Nerve injury and regeneration
- Colorectal Cancer Screening and Detection
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Zebrafish Biomedical Research Applications
- Advanced MRI Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Blood disorders and treatments
- Signaling Pathways in Disease
- Vestibular and auditory disorders
Medical University of South Carolina
2024
University of Charleston
2024
Rutgers New Jersey Medical School
2023
Rutgers, The State University of New Jersey
2023
Brigham and Women's Hospital
2015
Harvard University
2015
University of Massachusetts Chan Medical School
2013
Michigan State University
2012
Dendrite and synapse development are critical for establishing appropriate neuronal circuits, disrupted timing of these events can alter neural connectivity. Using microarrays, we have identified a nuclear factor I (NFI)-regulated temporal switch program linked to dendrite formation in developing mouse cerebellar granule neurons (CGNs). NFI function was required upregulation many synapse-related genes as well downregulation expressed immature CGNs. Chromatin immunoprecipitation analysis...
Degeneration of mesencephalic dopaminergic (mesDA) neurons is the pathological hallmark Parkinson's diseae. Study biological processes involved in physiological functions and vulnerability death these imparative to understanding underlying causes unraveling cure for this common neurodegenerative disorder. Primary cultures mesDA provide a tool investigation molecular, biochemical electrophysiological properties, order understand development, long-term survival degeneration during course...
The human small nuclear RNA (snRNA) and cytoplasmic (scRNA) gene families encode diverse non-coding RNAs that influence cellular growth division. Many snRNA scRNA genes are related via their compact yet powerful promoters support polymerase III transcription. We have utilized the U6 family to examine mechanism for regulated transcription of these potent units. Analysis nine members showed enriched CpG density within actively transcribed loci relative inert genes, implying a relationship...
Degeneration of mesencephalic dopaminergic (mesDA) neurons is the pathological hallmark Parkinson's diseae. Study biological processes involved in physiological functions and vulnerability death these imparative to understanding underlying causes unraveling cure for this common neurodegenerative disorder. Primary cultures mesDA provide a tool investigation molecular, biochemical electrophysiological properties, order understand development, long-term survival degeneration during course...
Deep brain stimulation (DBS) surgery, targeting various regions of the such as basal ganglia, thalamus, and subthalamic regions, is an effective treatment for several movement disorders that have failed to respond medication. Recent progress in field DBS surgery has begun extend application this surgical technique other conditions diverse morbid obesity, depression obsessive compulsive disorder. Despite these expanding indications, little known about underlying physiological mechanisms...
Deep brain stimulation (DBS) surgery, targeting various regions of the such as basal ganglia, thalamus, and subthalamic regions, is an effective treatment for several movement disorders that have failed to respond medication. Recent progress in field DBS surgery has begun extend application this surgical technique other conditions diverse morbid obesity, depression obsessive compulsive disorder. Despite these expanding indications, little known about underlying physiological mechanisms...
Abstract: MRI-guided focused ultrasound (MRgFUS) is being considered in the treatment of movement disorders like essential tremor and Parkinson's disease has shown promising preliminary results both terms effectiveness safety. However, several technical challenges have come to light that must be addressed. This review examines studies using MRgFUS treat discusses following challenges: adequate energy delivery with brachycephalic dense skulls, adverse events related procedural time, need...
Objective: Hypertensive urgency is generally defined as a severely elevated blood pressure without evidence of end-organ damage. Consensus statements do not recommend the acute lowering nor referral to emergency room. Rapid in patients who are chronically hypertensive carries risk hypoperfusion and therefore ischemia vital organs. The objective this study was assess residents’ perception management urgency. Methods: An anonymous survey sent via email all active resident physicians an...