A5016246154- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Radiomics and Machine Learning in Medical Imaging
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Pelvic and Acetabular Injuries
- Oral and Maxillofacial Pathology
- Cancer Research and Treatments
- Spine and Intervertebral Disc Pathology
- Neurosurgical Procedures and Complications
- Neuroblastoma Research and Treatments
- Bone Tumor Diagnosis and Treatments
- Intracranial Aneurysms: Treatment and Complications
- MRI in cancer diagnosis
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Nerve injury and regeneration
- Bioinformatics and Genomic Networks
- Neurogenesis and neuroplasticity mechanisms
- Advanced Electron Microscopy Techniques and Applications
- Anatomy and Medical Technology
Neurological Surgery
2021-2024
Oregon Health and Science University Hospital
2024
Oregon Health & Science University
2022-2024
University of California, San Diego
2021-2023
Rady Children's Hospital-San Diego
2023
Wayne State University
2019-2020
Detroit Medical Center
2019-2020
Stony Brook University
2019
Seattle Foundation
2019
Seattle University
2019
Quantitative imaging stratifies glioblastoma into three different phenotypes with distinct molecular activities independent of established markers and clinical status.
<h3>BACKGROUND AND PURPOSE:</h3> Tumor location has been shown to be a significant prognostic factor in patients with glioblastoma. The purpose of this study was characterize glioblastoma lesions by identifying MR imaging voxel-based tumor features that are associated molecular profiles, patient characteristics, and clinical outcomes. <h3>MATERIALS METHODS:</h3> Preoperative T1 anatomic images 384 glioblastomas were obtained from 2 independent cohorts (<i>n</i> = 253 the Stanford University...
Single position lateral fusion reduces the need for a secondary surgery and robotic guidance allows potentially higher accuracy of screw placement. We expand role robotics with simultaneous workflow where 2 surgeons can work in single discuss technical feasibility placement S2-alar-iliac (S2AI) screws position. A 70-year-old male presented chronic back pain bilateral leg left side worse than right. He subsequently underwent an L3–S1 oblique lumbar interbody (OLIF) minimally invasive L3-ilium...
Objective . Primary intramedullary spinal germ cell tumors are exceedingly rare. As such, there no established treatment paradigms. We describe our management for and a review of the literature. Clinical Presentation case 45-year-old man with progressive lower extremity weakness sensory deficits. He was found to have enhancing mass lesions in thoracic cord, pathology consistent an tumor. A video presentation surgical approach is provided. Conclusion cord germinomas highly sensitive radiation...
<b><i>Background:</i></b> There are currently no clear guidelines for the management and radiological monitoring of pediatric patients with epidural hematomas (EDH). We aim to compare clinical radiographic characteristics EDH managed observation alone versus surgical evacuation describe results repeat head imaging in both groups. <b><i>Methods:</i></b> performed a retrospective observational study diagnosed traumatic at level II trauma center....
Giant occipital encephalocele is a rare form of congenital anomaly that involves protrusion brain tissue (greater in size than the patient's cranial cavity) from defect skull. This case reports illustrates repair giant and emphasizes important methods to reduce risk for blood loss other complications.
Surgical treatment for tethered cord syndrome (TCS) involves a laminotomy intradural lysis of filum terminale (LFT), with the goal releasing excess tension on conus medullaris by dividing terminale. While LFT alleviates clinical symptoms, it is associated risks and complications, including cerebrospinal fluid (CSF) leak infection, either superficial or deep. Some complications relate to efficiency quality primary dural closure its downstream effects. We sought assess utility nonpenetrating...
Introduction: An encephalocele is a type of cranial dysraphism characterized by herniation intracranial contents including meninges, brain, blood vessels, and ventricular components through midline calvarial defect. As rare form neural tube defect, their etiology involves defective embryogenesis that can occur spontaneously or in association with early gestational exposures. A congenital anomaly, giant occipital protrusion brain tissue from defect the skull (in this case occiput). While...
Minimally invasive (MIS) approaches to neurosurgical diseases continue increase in popularity due their association with decreased infection risk, shorter recovery time, and improved cosmesis. Cosmesis lower morbidity are especially important for pediatric patients. The supraorbital keyhole craniotomy (SOKC) is one MIS approach shown be effective both neoplastic vascular pathologies However, it limited data on its use trauma Two cases employing SOKC patients presented here along a systematic...
Introduction: The traditional pterional craniotomy provides access to the anterior and middle fossa, however it has been associated with poor cosmesis, facial nerve injury, extensive skin retraction. micropterional or keyhole (PKC) same advantages as while reducing overall surgical exposure. It observed decrease length of hospital stay, operative time, well improve cosmetic outcomes following surgery for lesions adjacent pterion. Overall, demonstrates a promising trajectory within...
INTRODUCTION: Glioblastoma is the most common and aggressive primary human brain cancer. Noninvasive characterization of intratumor blood flow parameters may help guide clinical decision making. Beyond risk stratification prognostication, tumor perfusion inform treatment selection serial monitoring newer antiangiogenic targeted therapies. In this study, intra- intertumor variations in volume were quantified by using a novel 3-D volumetric, dynamic-susceptibility contrast-enhanced (DSCE),...
Chordomas are rare malignant neoplasms that develop from the primitive notochord with < 5% of tumors occurring in pediatric patients younger than age 20. Of these chordomas, those affecting craniocervical junction (C1-C2) even more rare; therefore, parameters for surgical management not well characterized.In this case, a 3-year-old male was found to have clival chordoma on imaging extension resulting spinal cord compression. Endoscopic-assisted transoral transclival approach tumor resection...
Gunshot wounds represent the second most frequent cause of spinal cord injury after vehicular trauma. The thoracic region is commonly involved, followed by thoracolumbar spine. Numerous studies have demonstrated that improvement neurological recovery, especially decompression surgery, likely to be seen in lumbosacral spine, but not or cervical Herein, we present a case gunshot wound causing lumbar 5th nerve root compression with deficits improved remarkably urgent surgery. This signifies...
Objective: Chordomas are rare malignant neoplasms that develop from the primitive notochord. These mostly occur in adults between ages of 30 and 70 while only <5% chordomas patients younger than age 20. Thus, pediatric population even more infrequent, parameters for surgical management affecting craniocervical (C1–2) junction not well characterized. Given there no definitive guidelines regarding treatment these tumors, we have reviewed evidence published to date on feasibility approaches...
We sought to discover subtypes of glioblastoma (GBM) defined by quantitative imaging features and identify their canonical signaling pathways. Preoperative MR from 121 Stanford patients with de novo, focal, unilateral GBM were analyzed. Two board-certified neuroradiologists a neurosurgeon reached consensus in delineating Regions-of-Interest (ROIs) around areas enhancement each T1 post-contrast MR. extracted 138 image representing signal intensity morphology lesion. then used Consensus...