A5041948804- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Hernia repair and management
- Glycosylation and Glycoproteins Research
- DNA Repair Mechanisms
- Cancer Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Monoclonal and Polyclonal Antibodies Research
- 14-3-3 protein interactions
- Fungal and yeast genetics research
- Cancer Cells and Metastasis
- Abdominal Surgery and Complications
- T-cell and B-cell Immunology
- Breast Cancer Treatment Studies
- Multiple and Secondary Primary Cancers
- Gastric Cancer Management and Outcomes
- COVID-19 and healthcare impacts
- Testicular diseases and treatments
- Hematopoietic Stem Cell Transplantation
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2019-2024
Semmelweis University
2002-2020
University of California, Irvine
2005-2010
St. John's University
2010
Stanford University
2004
University of Pecs
2002
The aim of the present study was to classify colorectal carcinoma (CRC) into molecular subtypes, based on immunohistochemical (IHC) assessments. A total 112 CRC samples were molecularly classified expression levels epithelial‑mesenchymal transition (EMT)‑associated IHC markers. three subtypes defined: Epithelial, membrane positivity for E‑cadherin and β‑catenin, negative vimentin; mesenchymal, E‑cadherin‑negative, nuclear β‑catenin‑ vimentin‑positive; hybrid cases, epithelial tumor core...
Despite the description of several new prognostic markers, colorectal cancer still represents third most frequent cause cancer-related death. As immunotherapy is considered a therapeutic alternative in such patients, neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratio (LMR) are hypothesized to provide reliable information. A retrospective study was conducted on 1052 patients operated during 2013-2019 two clinical hospitals from Hungary Romania. Inclusion criteria targeted over 18...
Mediastinal (thymic) large B-cell lymphoma (MBL) has been defined as a subtype of diffuse (DLBL) arising in the mediastinum with characteristic clinicopathological features. It postulated that MBL arise from non-circulating thymic B-cells and represent distinct entity, however, histogenesis disease is not yet fully understood. In order to clarify histogenetic derivation determine relationship we have analyzed nucleic acid sequences immunoglobulin (Ig) heavy chain variable region (VH) 5'...
Although amplification of the gene encoding human epidermal growth factor receptor 2 (HER2) is used as an indicator for response to trastuzumab, reported rate low, and few patients with gastric cancer (GC) benefit from this individualized therapy. The aim study was examine expression c-erbB-2 oncoprotein (HER2), in GC samples, using two commercial immunohistochemical (IHC) antibodies, validate results by checking HER2 fluorescence situ hybridization (FISH).We assessed IHC polyclonal antibody...
Gliomas are characterized by highly variable biological behavior. After surgical resection and postoperative therapy they frequently recur with the same or higher-grade histology. Although a number of genetic aberrations have been described in gliomas different histological types, molecular mechanisms clinical progression poorly understood. In this study, we performed longitudinal microsatellite mismatch repair gene analysis paired samples primary recurrent order to reveal whether...
Background: The novel coronavirus, SARS-COV-2, was first reported in Wuhan, China the end of 2019. To curb its spread, social distancing measures and new safety regulations were implemented which led to major disruptions colorectal cancer care. It is however unknown how it influenced Romanian Methods Material: We assessed demographical, clinical, intraoperative pathological data our patients, 302 total, between 15.03.2019-14.03.2021. year's considered as control group second one, study...
We hypothesized that different BC subtypes are characterized by spatially distinct tumor immune microenvironment (TIME) and gene assembly of metastatic (Met) non-metastatic (Ctrl) BCs vary across subtypes. Peritumoral, stromal intratumoral TIL was assessed on 309 cases. Hot, cold immune-excluded groups were defined, the prognostic role this classification assessed. CD4+/CD8+ positivity analyzed in 75 cases four systematically predefined regions. Immune expression Met Ctrl HER2-negative...
Background: In patients with synchronous colorectal cancer (SCRC), understanding the underlying molecular behavior of such cases is mandatory for designing individualized therapy. The aim this paper to highlight importance transdisciplinary evaluation pre- and post-operative assessment SCRCs, from imaging investigations. Methods: Six SCRCs presented two carcinomas each. addition microsatellite status (MSS), epithelial mesenchymal transition was checked in each tumor using biomarkers...
Esophageal carcinoma is an aggressive cancer with a poor therapeutic response and significant risk of recurrence after radical resection. It usually metastasizes to the lung, bones, or liver. Unusual spread can be found in other organs, but only nine cases pancreatic metastases have been reported Medline database. In present paper, literature review esophageal squamous cell metastasis was carried out. addition these cases, we our case, tenth case literature. involved patient who underwent...
Absztrakt: Bevezetés: Az óriás hasfali defektusok kezelése kihívást jelent a sebészek számára. CT-vizsgálattal meghatározható sérvzsák és hasüreg térfogata közötti arány, megállapítva téraránytalanság mértékét, amely műtét utáni hasűri nyomás mértékének kifejezője lehet. Célkitűzés: A posztoperatív kivizsgálásában alkalmazott CT-vizsgálat jelentőségének alátámasztása, rekonstrukciós módszer hatékonyságának elemzése hasűrinyomás-méréssel. Módszer: Prospektív kutatást végzünk klinikánkon,...
Preoperative staging of colorectal cancer (CRC) based on imaging techniques such as computed tomography (CT) or magnetic resonance (MRI) is crucial for identification and then removal the positive lymph nodes (LNs). The aim this study was to evaluate correlation between preoperatively seen morphologic criteria (number, size, shape, structure, borders, enhancement patterns) histopathological features LNs using an in-house validated map nodal stations. A total 112 patients with CRC that...
Somatic hypermutation (SHM) and class switch DNA recombination (CSR) are central to the maturation of antibody response occur mainly in germinal centers (GCs). To identify critical (S) region cis ‐elements, we analyzed S sequences identified AGCT motifs occurring at a high frequency Sμ all other downstream regions human, mouse Xenopus laevis . 14‐3‐3 adaptor proteins were major AGCT‐binding preferentially localized switching B cells. Expression was induced GC cells vivo stimulated undergo...
A collecting duct carcinoma is a very rare, malignant renal epithelial tumor. Distant metastases are present in one third of cases at the time diagnosis. It known to have poor prognosis.A 42-year-old male was sent our surgery clinic for removal 119.2 mm × 108.3 encapsulated cystic mass, which localized 8th segment right liver lobe. The lesion first identified on ultrasonography. computed tomography scan confirmed presence Bosniak type III lesion, affected and convexity kidney. Surgical...
Follicular lymphoma (FL) is an indolent, B-cell, non-Hodgkin’s with varying cytological appearance and clinical behavior. The genetic hallmark of FL the t(14;18) translocation, as a germinal center derived entity it also characterized by somatic hypermutation immunoglobulin heavy chain (IgH) gene. In attempt to correlate this molecular signature grading FL, we have analyzed IgH variable (IgVH), regions in all grades FL. Four cases showing translocation were classified into grade I-III...
Abstract Introduction: Massive ventral hernia repairs may lead to abdominal compartment syndrome, which is associated with increased morbidity and mortality, caused by an acute rise in intra-abdominal pressure, frequently leading multi-organ failure possibly death. This report presents a case voluminous incisional intestine obstruction the issues surrounding emergency surgical treatment. Case report: An overweight 67-year-old patient medical history of diabetes multiple cardiovascular...