A5101846495- Malaria Research and Control
- Antibiotics Pharmacokinetics and Efficacy
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects of Medicinal Plants
- Natural Antidiabetic Agents Studies
- Pharmacological Effects and Toxicity Studies
- Energy Efficient Wireless Sensor Networks
- Drug Solubulity and Delivery Systems
- Phytochemicals and Medicinal Plants
- Estrogen and related hormone effects
- Natural product bioactivities and synthesis
- Biosimilars and Bioanalytical Methods
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Medicinal Plants and Neuroprotection
- Chromatography in Natural Products
- Skin Protection and Aging
- Synthesis and biological activity
- Advanced Drug Delivery Systems
- Hormonal and reproductive studies
Central Drug Research Institute
2010-2021
Academy of Scientific and Innovative Research
2015-2021
Weatherford College
2017
GTx (United States)
2017
Tata Steel (India)
2010
Heidelberg University
2004
Heidelberg University
2004
Advances in wireless sensor network (WSN) technology has provided the availability of small and low-cost nodes with capability sensing various types physical environmental conditions, data processing, communication.Variety capabilities results profusion application areas.However, characteristics networks require more effective methods for forwarding processing.In WSN, have a limited transmission range, their processing storage as well energy resources are also limited.Routing protocols...
Radio transmission and reception consumes a lot of energy in wireless sensor network (WSN), which are made low-cost, low-power, small size, multifunctional nodes.Thus, one the important issues is inherent limited battery power within nodes.Therefore, crucial parameter algorithm design maximizing lifespan nodes.It also preferable to distribute dissipated throughout order maximize overall performance.Much research has been done recent years area low routing protocol, but, there still many...
The hybrid congeners 62-90 of 6- and 7-hydroxyflavones with aminopropanol have been synthesized evaluated for their antidiabetic activity in sucrose-challenged low-dosed streptozotocin (STZ)-induced diabetic rats db/db mice. optical enantiomers 70a, 70b, 90a, 90b two 70 90 exhibiting consistent antidyslipidemic activities were also prepared, results indicate its association mainly S isomers. These compounds lower cholesterol TG profiles while improving high-density lipoprotein to CHOL ratio...
Levofloxacin (LVFX) is a broad spectrum third generation fluoroquinolone antibiotic, used in the treatment of severe or life-threatening bacterial infections. Photosensitizing mechanism LVFX was investigated under ambient environmental intensities UV-A, UV-B and sunlight exposure. Phototoxic effects were assessed on NIH-3T3 HaCaT cell lines. Results identified first time three photoproducts at levels UV-R by LC-MS/MS. The reactive oxygen species (ROS) photochemically as well intracellularly...
Riboflavin (RF) or vitamin B2 is known to have neuroprotective effects. In the present study, we report attenuation of effects RF under UV-B irradiation. Preconditioning irradiated riboflavin (UV-B-RF) showed attenuated compared that in SH-SY5Y neuroblostoma cell line and primary cortical neurons vitro a rat model cerebral ischemia vivo. Results indicated pretreatment significantly inhibited death reduced LDH secretion UV-B-RF neuron cultures subjected oxygen glucose deprivation brain tissue...
Intranasal administration can potentially deliver drugs to the brain because of proximity delivery site olfactory lobe. We prepared triturates micronized or crystalline zolmitriptan with a GRAS substance, nicotinamide, form eutectic. characterized formulation using differential scanning calorimetry, powder X-ray diffraction, and FTIR spectroscopy confirm its eutectic nature generated phase diagram. The was aerosolized an in-house insufflator into nares rats. Groups rats received...
Tamoxifen and centchroman are two non-steroidal, selective estrogen receptors modulators, intended for long term therapy in the woman. Because of their wide spread use, there is a possibility co-prescription these agents.We studied probable pharmacokinetic interaction between agents breast cancer model rats. A simple, sensitive rapid LC-ESI-MS/MS method was developed validated simultaneous determination tamoxifen, active metabolites.The linear over range 0.2-200 ng/ml. All validation...
A stage-dependent increase in the level of putrescine, spermidine, and spermine during intraerythrocytic growth Plasmodium knowlesi rhesus monkey erythrocytes was observed. Further, P. knowlesi-induced putrescine influx found trophozoite stage-infected process time- temperature-dependent showed saturable kinetics. Characteristics induced appears infected to be close normal terms affinity transporter (Km 34.6 +/- 3.8 microM as Km 37.2 5.2 erythrocytes). However, difference involves...
Abstract This study aimed to analyze the phototoxic mechanism and photostability of quinine in human skin cell line A375 under ambient intensities UVA (320–400 nm). Photosensitized produced a photoproduct 6‐methoxy‐quinoline‐4‐ylmethyl‐oxonium identified through LC‐MS/MS. Generation 1 O 2 , •− • OH was measured further substantiated their respective quenchers. Quinine (Q) caused degradation 2‐deoxyguanosine, most sensitive nucleotide UV radiation. The intracellular ROS increased...
Abstract Preclinical Research & Development Withanolide A (WA), a steroidal lactone is major bioactive constituent of Withania somnifera (L.) with remarkable neuropharmacological activity. In this study, we investigated the permeability, plasma protein binding (PPB), blood partitioning, intravenous (i.v.), and oral pharmacokinetics as well i.v. tissue distribution (TD) pure WA in rat model. The PPB, RBCs permeability were determined by Ultra Performance Liquid Chromatography (UPLC)...
ObjectivesThis manuscript addresses key pharmacokinetic issues in support of the development a potent candidate lipid-lowering drug molecule, 16-dehydropregnenolone (DHP).
Guggulsterone is an active constituent of guggulipid, ayurvedic drug derived from Commiphora mukul, and reported to have hypolipidaemic activity. The pharmacokinetics Z-guggulsterone (1a) its metabolite, E-guggulsterone (1b), was studied in rats after oral (50 mg kg−1) intravenous (18 administration 1a. It observed that 1a isomerized 1b treated rat serum samples. Serum levels gugulsterone showed a biexponential elimination phase with mean ± s.d. terminal half-life 10.02 4.74 h 9.24...