A5082964115- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Radiation Detection and Scintillator Technologies
- Gallbladder and Bile Duct Disorders
- Atomic and Subatomic Physics Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hepatitis C virus research
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging Techniques and Applications
- Semiconductor Lasers and Optical Devices
- Cancer Cells and Metastasis
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Photonic and Optical Devices
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Advanced Optical Sensing Technologies
- Colorectal Cancer Treatments and Studies
- Potassium and Related Disorders
- Cancer Genomics and Diagnostics
University of Fukui
2016-2025
University of Fukui Hospital
2025
Obayashi (Japan)
2022
Weatherford College
2022
Kyushu Institute of Technology
1988-2016
Waseda University
2002-2014
Hitachi (Japan)
2005
Socionext (Japan)
2002-2003
Fukui University of Technology
2002
University of Stuttgart
1973
Abstract Objectives The causes of drug‐induced gastroduodenal injuries primarily include antithrombotic drugs, including low‐dose aspirin, non‐steroidal anti‐inflammatory and corticosteroids. These drugs are suspected to affect gastric ulcer healing after endoscopic submucosal dissection (ESD). This study aimed investigate the effects these on post‐ESD healing. Methods included 170 lesions (149 patients) who had undergone ESD for early cancer. Post‐ESD ulcers were endoscopically measured...
To cure hepatitis B virus (HBV) infection, it is essential to elucidate the function of hepatocyte host factors in regulating viral life cycle. Signaling and transcription activator (STAT)1 play important roles immune responses, but STAT1-independent pathways have also been shown biological reactivity. Using an vitro HBV infection assay system, current study aimed investigate that contribute control by comprehensive functional screening. The system was established using primary human...
Abstract The mechanism of intergranular-mode fracture in hydrogen-related failure high-strength martensitic steels has been investigated. Pronounced degradation tensile properties appeared with increasing manganese content a slow-elongation-rate test under concurrent hydrogen charging. mode was intergranular tear traces along martensite lath boundaries. disappeared and the average surface roughness decreased content. Thermal desorption analysis charged to deformed specimens conducted using...
Arachidonic acid 5-lipoxygenase (5-LOX), an enzyme that synthesizes leukotrienes (LTs), is involved in cancer development including proliferation, invasion, metastasis and drug resistance. However, the functional role of 5-LOX hepatocellular carcinoma (HCC) remains to be elucidated. In this study, we analyzed contribution HCC progression investigated potential targeted therapy. Analysis 86 resected specimens clinical data 362 cases liver from The Cancer Genome Atlas Liver Hepatocellular...
There remains no reliable biomarker of therapeutic efficacy in hepatocellular carcinoma (HCC) for the PD-L1 inhibitor atezolizumab and bevacizumab (Atezo/Bev). Circulating tumor cells (CTCs) enable serial collection living cells. Pre-treatment CTC gene expression changes histology were evaluated to identify predictors response Atezo/Bev. Peripheral blood from 22 patients with HCC treated Atezo/Bev 24 lenvatinib was serially collected. The RNA CTCs analyzed using qRT-PCR. Higher pre-treatment...
Background Achieving sustained virologic response (SVR) in patients infected with hepatitis C virus (HCV) reduces all-cause mortality. However, the mechanisms and risk factors for liver fibrosis portal hypertension post-SVR remain incompletely understood. In gut-liver axis, mucosa-associated microbiota (MAM) substantially influence immune metabolic functions, displaying spatial heterogeneity at anatomical intestinal site. We analyzed MAM composition function to isolate locoregional involved...
Metastasis to the pituitary gland is extremely rare and often detected incidentally by symptoms associated with endocrine dysfunction. Breast lung cancer are most common primary metastasizing gland. from hepatocellular carcinoma rare, only 10 cases having been previously reported. We present here first case of metastasis presenting panhypopituitarism diagnosed magnetic resonance imaging.We report an 80-year-old Japanese woman who presented sudden onset hypotension bradycardia after...
Abstract The present study aimed to establish a novel isolation strategy for circulating tumor cells (CTCs) using microcavity array (MCA) system and evaluate the clinical significance of CTCs in hepatocellular carcinoma (HCC). We examined recovery rates HCC cell lines spiked into whole blood MCA assay. Circulating were isolated from peripheral samples (3 mL) 7 healthy donors (HD), 14 patients with liver cirrhosis (LC), 31 system. Additionally, we investigated mRNA expression liver‐specific...
Primary neoplasms of the small intestine are relatively rare in all age groups, accounting for about 5 % gastrointestinal tumors 1. Cavernous hemangiomas also rare, can cause bleeding, and extremely difficult to diagnose preoperatively 2. We present a patient who presented with melena iron deficiency anemia, whom wireless capsule endoscopy single-balloon enteroscopy facilitated diagnosis cavernous hemangioma.
Immune checkpoint inhibitors have promising outcomes in patients with hepatocellular carcinoma (HCC); however, there is no reliable biomarker for predicting disease progression. Circulating tumor cells (CTCs) derived from peripheral blood attracted attention monitoring therapeutic efficacy. In this study, CTCs were serially collected HCC undergoing atezolizumab plus bevacizumab (Atezo+Bev), and changes molecular expression CTC numbers analyzed to identify effective biomarkers. Changes during...
We report the development of a monolithic MPPC array, which consists 3 × mm2 elements arranged as 4 array manufactured by Hamamatsu applicable to next generation PET scanners. show that is suitable for time flight applications simple measurement using coincident back-to-back 511 keV gamma rays. demonstrated has much better timing resolution ∼ 600 ps than APD. coupled with Ce:LYSO and Pr:LuAG scintillator matrices gamma-ray detectors. The energy resolutions were evaluated 14% 662 gamma-rays...
Hepatitis B virus (HBV) reactivation can be triggered by immunosuppressive chemotherapy. HLA class II molecules may play a role in HBV reactivation. Genetic polymorphism and mRNA expression of were examined patients with latent infection treated therapies. Subjects resolved who had undergone treatment chemotherapies retrospectively enrolled ( n = 42) divided into reactivated 9) non‐reactivated groups 33). Patients genotyped for 17 single nucleotide polymorphisms (SNPs) within DPA1 , DPB1...
Circulating tumor cells (CTCs) are noninvasive biomarkers that can indicate the therapeutic response and prognosis. The study aimed to investigate cellular characteristics of CTCs focusing on monitoring during atezolizumab bevacizumab (Atezo-Bev) therapy in patients with hepatocellular carcinoma (HCC). Peripheral blood samples were collected from 10 healthy controls 40 HCC. enriched using RosetteSep™ Human CD45 depletion cocktail analyzed by multiparametric flow cytometry. CTC isolation was...
The spontaneous rupture of hepatic metastases is rare compared to that primary tumors. In addition, vemurafenib, a selective inhibitor the mutant BRAF protein or gene product, has been reported be extremely effective in patients with metastatic melanoma who harbor V600E mutation.A 44-year-old female had previously undergone surgery for resection malignant lower right leg. Four years later, became apparent, and transcatheter arterial embolization (TAE) was performed. Then she underwent...
Abstract Background Histological evaluation by liver biopsy is considered the gold standard for assessing disease; however, it highly invasive. Non-invasive stiffness measurement shear wave elastography (SWE) effective evaluating hepatic fibrosis stage and related diseases. In this study, we investigated correlations of with inflammation/fibrosis, functional reserve, diseases in patients chronic disease (CLD). Methods Shear velocity (Vs) values were measured using point SWE 71 from 2017 to...