A5062854514- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- Genetic Associations and Epidemiology
- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Neurogenetic and Muscular Disorders Research
University of Pennsylvania
2022-2023
University of Cincinnati Medical Center
2021
Genetic risk can influence disease progression. We measured the impact of genetic for substance use disorders (SUDs) on onset and progression symptoms.
Neonatal brachial plexus injury (NBPI) causes disabling and incurable muscle contractures that are driven by impaired growth of denervated muscles. A rare form NBPI, which maintains afferent innervation despite motor denervation, does not cause contractures. As regulates various aspects skeletal homeostasis through NRG/ErbB signaling, our current study investigated the role this pathway in modulating contracture development. Through pharmacologic modification with an ErbB antagonist NRG1...
Abstract Background Charting the clinical course of substance use disorders (SUDs) to identify etiologic contributors milestone onset and progression could inform intervention efforts. Methods We calculated polygenic risk scores (PRS) in 5,692 European-ancestry individuals (EUR) (56.2% male) 4,918 African-ancestry (AFR) (54.9% using genome-wide association studies (GWAS) alcohol disorder (AUD), opioid (OUD), smoking trajectory (SMK). Using Cox regression, we examined with age first use,...