A5100641495- DNA Repair Mechanisms
- Protein Structure and Dynamics
- Machine Learning in Materials Science
- Computational Drug Discovery Methods
- Plant Water Relations and Carbon Dynamics
- Biofuel production and bioconversion
- Digital Imaging for Blood Diseases
- Photosynthetic Processes and Mechanisms
- NF-κB Signaling Pathways
- Enzyme Production and Characterization
- Microbial Metabolism and Applications
- Leaf Properties and Growth Measurement
- Genomics and Chromatin Dynamics
- interferon and immune responses
- Muscle Physiology and Disorders
- Cell Image Analysis Techniques
- Iterative Learning Control Systems
- Genomic variations and chromosomal abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- Plant Stress Responses and Tolerance
- Advanced Algorithms and Applications
- Microtubule and mitosis dynamics
- Plant and animal studies
- Prenatal Screening and Diagnostics
- Mesenchymal stem cell research
Qiqihar University
2025
Nanjing Foreign Language School
2025
University of Oxford
2020-2024
Purdue University West Lafayette
2024
Guangxi University
2018-2019
Nanyang Technological University
2009
Genome Institute of Singapore
2009
As technology advances, so does digital farming, revolutionizing the industry. Drones, sprayers equipped with GPS and other sensors, combine harvesters, machinery can greatly improve agricultural productivity. This paper studies impact of straw baler screw conveyor on efficiency baler. Via theoretical analysis, GA—BP (Genetic Algorithm—Back Propagation) simulation, comparative experiments, structural parameters rotational speed spiral shaft in conveying device are optimized. In this paper,...
This paper provides an exhaustive evaluation of different algorithms for the accurate detection and localization dense clusters on complex image data with a resolution to maintain real centroids in obscure, overlapping, or densely packed situations. Our approach differs by its use local maximum algorithm quickly identify potential cluster centers (by detecting maxima pixel intensity) as first step. The starts initializing centers, which are then refined using k-Means clustering method that...
The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs) in humans. Activation of the relies on loading FANCD2/FANCI complex onto chromosomes, where it is fully activated by subsequent monoubiquitination. However, mechanism for chromosomes remains unclear. Here, we identify 10 SQ/TQ phosphorylation sites FANCD2, which are phosphorylated ATR response to ICLs. Using a range biochemical assays complemented with live-cell imaging including super-resolution single-molecule...
Abstract Molecule property prediction has gained significant attention in recent years. The main bottleneck is the label insufficiency caused by expensive lab experiments. In order to alleviate this issue and better leverage textual knowledge for tasks, study investigates feasibility of employing natural language instructions accomplish molecule-related tasks a zero-shot setting. We discover that existing molecule-text models perform poorly setting due inadequate treatment limited capacity...
Raw-starch-digesting glucoamylases (RSDGs) from filamentous fungi have great commercial values in starch processing; however, the regulatory mechanisms associated with their production remain unknown. Penicillium oxalicum HP7-1 isolated by our laboratory secretes RSDG suitable properties but at low levels. Here, we screened and identified novel regulators of gene expression P. through transcriptional profiling genetic analyses. transcriptomes presence glucose starch, respectively, used as...
<title>Abstract</title> In drug discovery, molecular dynamics (MD) simulation for protein-ligand binding provides a powerful tool predicting affinities, estimating transport properties, and exploring pocket sites. There has been long history of improving the efficiency MD simulations through better numerical methods and, more recently, by utilizing machine learning (ML) methods. Yet, challenges remain, such as accurate modeling extended-timescale simulations. To address this issue, we...
The Fanconi anemia (FA) pathway removes interstrand crosslinks (ICLs) between the Watson-Crick strands of DNA double helix in humans. Central to is FANCD2/FANCI complex, which must be loaded onto chromosomes. Here, we report identification a PP2A phosphatase specifically dephosphorylates an inhibitory cluster FANCD2, thereby licensing its loading response damage. We show that required for normal monoubiquitination complex and have fully reconstituted coupled dephosphorylation-ubiquitination...
Summary Leaf vein network geometry can predict levels of resource transport, defence, and mechanical support that operate at different spatial scales. However, it is challenging to quantify architecture across scales, due the difficulties both in segmenting networks from images, extracting multi-scale statistics subsequent graph representations. Here we develop deep learning algorithms using convolutional neural (CNNs) automatically segment leaf networks. Thirty-eight CNNs were trained on...
In the Dialogue for Reverse Engineering Assessments and Methods Conference (DREAM2) BCL6 target identification challenge, we were given a list of 200 genes tasked to identify which ones are true targets using an independent panel gene-expression data. Initial efforts conventional motif-scanning approaches find binding sites in promoters as means identifying proved unsuccessful. Instead, performed large-scale comparative study multiple expression data under different conditions. Specifically,...