P Sasidharan

ORCID: 0000-0002-0883-8508
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About
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Research Areas
  • Neonatal Respiratory Health Research
  • Congenital Diaphragmatic Hernia Studies
  • Neuroscience of respiration and sleep
  • Neonatal Health and Biochemistry
  • Birth, Development, and Health
  • Respiratory Support and Mechanisms
  • Neonatal and fetal brain pathology
  • Infant Development and Preterm Care
  • Tracheal and airway disorders
  • Erythrocyte Function and Pathophysiology
  • Infant Nutrition and Health
  • Congenital Heart Disease Studies
  • Neonatal and Maternal Infections
  • Sepsis Diagnosis and Treatment
  • Regulation of Appetite and Obesity
  • Blood groups and transfusion
  • Adipose Tissue and Metabolism
  • Antifungal resistance and susceptibility
  • Fungal Infections and Studies
  • Cardiovascular Function and Risk Factors
  • Hemoglobinopathies and Related Disorders
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Reconstructive Surgery and Microvascular Techniques
  • Streptococcal Infections and Treatments
  • Head and Neck Surgical Oncology

Amrita Institute of Medical Sciences and Research Centre
2007-2023

Amrita Vishwa Vidyapeetham
2017-2023

Sri Ramachandra Institute of Higher Education and Research
2017

Papworth Hospital
2014

Medical College of Wisconsin
1993-2010

Children's Hospital of Wisconsin
1996-2010

Baby Memorial Hospital
2000

Washington University in St. Louis
1999

St. Joseph's Hospital
1999

Illinois College
1988-1999

Respiration, as judged by gas exchange and pulmonary function, is improved in preterm infants kept the prone rather than supine position. The influence of position on breathing pattern documented pneumogram was studied 14 stable with recent clinical apnoea. Ten had oximetry nasal flow studies simultaneously impedance pneumogram. Each infant consecutive nocturnal pneumograms, one prone, were for more six hours assigned A significant increase apnoea density periodic found v (mean (SE) 4.5...

10.1136/adc.67.3.312 article EN Archives of Disease in Childhood 1992-03-01

Aim Our aim was to identify the clinical features and outcome of multidrug resistant Candida auris (CA) infection in neonates. Methods This is a retrospective case cohort study 17 neonates who developed sepsis caused by CA tertiary care neonatal intensive unit over 3 years. The risk factors, features, treatment were studied. Results mean gestation 32.4 ± 4.9 weeks with overall mortality 41%. Clinical indistinguishable from other causes sepsis. sensitive micafungin but fluconazole had...

10.1111/jpc.15019 article EN Journal of Paediatrics and Child Health 2020-07-16

10.1016/s0095-5108(18)30108-8 article EN Clinics in Perinatology 1998-09-01

In order to evaluate the effects of transfusion on breathing pattern in growing, otherwise healthy, anemic preterm infants, we studied 14 infants whose mean +/- SD birthweight was 1,212 294 grams, gestational age 29.28 2.23 weeks and hematocrit 25.86 2.24%. At a postnatal 41.35 19.45 days 12 hour nocturnal (transthoracic impedance) pneumocardiograms were obtained 24 hours prior after with 10 mL/kg packed red blood cells. Posttransfusion revealed significant reduction periodic breathing,...

10.1002/ppul.1950120308 article EN Pediatric Pulmonology 1992-03-01

10.1016/0002-9378(91)90367-z article EN American Journal of Obstetrics and Gynecology 1991-11-01

Sedation has been commonly used in the neonate to decrease stress and pain from noxious stimuli invasive procedures neonatal intensive care unit, as well facilitate synchrony between ventilator spontaneous breaths. Fentanyl, an opioid analgesic, is frequently unit setting for these very purposes. Various reported side effects of fentanyl administration include chest wall rigidity, hypotension, respiratory depression, bradycardia. Here, 2 cases urinary bladder retention leading renal...

10.1542/peds.108.4.1012 article EN PEDIATRICS 2001-10-01

Objective: Our objective was to examine the outcome of term infants who developed moderate non‐haemolytic jaundice as information regarding neurodevelopmental with moderately severe hyperbilirubinemia remains controversial. Study design: Thirty‐nine rehospitalised (serum bilirubin levels: 20–30 mg/dL) during first 2 weeks life (study group), were assessed and compared 36 children born at did not develop neonatal (control group). Assessment consisted Bailey test, speech evaluation,...

10.1111/j.1440-1754.2010.01800.x article EN Journal of Paediatrics and Child Health 2010-07-07

ABSTRACT Cases of invasive mycosis due to Blastobotrys serpentis and B. proliferans identified by sequencing in a preterm patient rhabdomyosarcoma patient, respectively, are reported. Both species revealed elevated fluconazole echinocandin MICs the CLSI broth microdilution method. Additionally, exhibited high amphotericin B MICs, thus posing serious therapeutic challenges.

10.1128/jcm.01977-14 article EN Journal of Clinical Microbiology 2014-08-28

Perinatal asphyxia is a cause of significant morbidity among full term infants, but breathing abnormalities after an asphyxic insult have not been studied. This report details patterns 16 asphyxiated during the first week life who were studied by transthoracic impedance pneumocardiograms. Pneumocardiograms abnormal in 69% infants group and 13% control group. Significant differences noted incidence prolonged apnoea, percentage periodic breathing, apnoea density. These results indicate that...

10.1136/adc.67.4_spec_no.440 article EN Archives of Disease in Childhood 1992-04-01

To examine causes of newborn hospital readmission and morbidity related to early nursery discharge, we reviewed the charts 664 newborns readmitted from home under age 15 days, between 1993 1995. Early discharge (ED) was defined as length stay < or = 2 days. Morbidity ED: onset symptoms within 1 day ED; in diseases with insidious onset: serum bilirubin level > 20 mg/dL (340 mumol/L), dehydration following poor breastfeeding since birth. Seventeen percent all infants had ED-related morbidity;...

10.1177/000992289803701003 article EN Clinical Pediatrics 1998-10-01

Pulmonary mechanics were studied in ten anemic preterm infants using an esophageal balloon and mask, before after transfusion with 10 ml/kg of packed RBC. Their mean birth weight was 1212 ± 323 g gestational age 29.27 2.4 wk. Transfusions carried out at a postnatal 41.9 21.8 days. The Hct increased from 28 3.1 to 38.3 3.3%. Dynamic lung compliance decreased all transfusion. There 33.8% increase resistance; the work breathing These changes might be due volume overload or water content.

10.1097/00003246-199012000-00010 article EN Critical Care Medicine 1990-12-01

To examine the value of current diagnostic tests identifying neonatal sepsis related to intrapartum treatment with antibiotics, we reviewed charts 219 mother-infant pairs, which 139 mothers received antibiotics (group 1) and 80 did not 2). When compared group 2 infants, 1 infants had fewer positive blood cultures (4.3% vs 20%, P&lt;0.003), for B streptococci (GBS) (P&lt;0.001), urine GBS latex agglutination (LA) (P &lt;0.001). Although sensitivity white cell count (WBC) was 81 %, specificity...

10.1177/000992289503400303 article EN Clinical Pediatrics 1995-03-01

A retrospective case-control study involving 99 premature infants requiring vigorous respiratory support was conducted to investigate the relative contribution of various etiologic factors in development chronic lung disease (CLD). Nineteen developed CLD. Background and management up CLD, with attention mode ventilation (tube, or face mask/nasal prongs) were investigated. Infants CLD group had significantly lower birth weights (BW) (p < .001) gestational ages .01) than those non-CLD group....

10.1097/00003246-198812000-00007 article EN Critical Care Medicine 1988-12-01

Background: The association of serum vitamin D levels to clinical outcome in VLBW infants has not been studied. Our objective was measure the cord blood levels, and dose response for two doses preterm correlate relationship outcome.Methods: We prospectively obtained 80 under 34 weeks gestation (mean age 29±2 BW: 1210±350 gms). Infants were supplemented with 400 IU or 800-1000 daily. Serun at 2 - 3 after supplementation correlated outcome. Results: mean level 12±8.5 ng/ml. Babies who...

10.18203/2349-3291.ijcp20170697 article EN International Journal of Contemporary Pediatrics 2017-02-22
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