A5111945885- Neonatal Respiratory Health Research
- Central Venous Catheters and Hemodialysis
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Infant Nutrition and Health
- Infective Endocarditis Diagnosis and Management
- Respiratory Support and Mechanisms
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Birth, Development, and Health
- Pneumonia and Respiratory Infections
- Poisoning and overdose treatments
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Mechanical Circulatory Support Devices
- Liver Disease Diagnosis and Treatment
- Traumatic Ocular and Foreign Body Injuries
- Antimicrobial Resistance in Staphylococcus
- Body Composition Measurement Techniques
Wheaton Franciscan Healthcare
2006-2017
St. Joseph Hospital
1994-2017
Tel Aviv Sourasky Medical Center
2017
Engineering Associates (United States)
2017
St. Joseph Medical Center in Tacoma
2016
St. Joseph's Hospital
1996-2016
St. Joseph Hospital
2016
Trinity Hospital of Augusta
2016
Queen's University
2013-2014
Children's Hospital of Wisconsin
1985-2011
Background. Infants developing bronchopulmonary dysplasia (BPD) show decreased cortisol response to adrenocorticotropic hormone. A pilot study of low-dose hydrocortisone therapy for prophylaxis early adrenal insufficiency showed improved survival without BPD at 36 weeks’ postmenstrual age, particularly in infants exposed histologic chorioamnionitis. Methods. Mechanically ventilated with birth weights 500 999 g were enrolled into this multicenter, randomized, masked trial between 12 and 48...
Neonates who require a central venous catheter (CVC) for prolonged vascular access experience high rates of catheter-related bloodstream infection (CRBSI). Purpose. A multicenter randomized clinical trial was undertaken to ascertain the efficacy novel chlorhexidine-impregnated dressing (Biopatch Antimicrobial Dressing) on CVC sites neonates prevention tip colonization, CRBSI, and (BSI) without source. Setting. Six level III neonatal intensive care units. Patients Studied. admitted study...
<h3>Objective:</h3> To determine to what extent the risk of bronchopulmonary dysplasia is affected by ventilatory management before first dose rescue artificial surfactant. <h3>Study Design:</h3> Retrospective cohort study. <h3>Subjects:</h3> One hundred eighty-eight low-birth-weight infants (≤1700 g) who received surfactant therapy for respiratory distress syndrome and were alive at 36 weeks gestational age. <h3>Outcome:</h3> Bronchopulmonary was defined a need supplemental oxygen maintain...
Objective.Critically ill neonates are at high risk for vascular catheter–related bloodstream infection (CRBSI), most often caused by coagulase-negative staphylococci. Most CRBSIs with long-term devices derive from intraluminal contaminants. The objective of this study was to ascertain the safety and efficacy a vancomycin-heparin lock solution prevention CRBSI. Methods.A prospective, randomized double-blind trial conducted during 2000–2001 community hospital level III NICU. Very low birth...
Objective. To better define the pathogenesis of catheter-related bloodstream infection (BSI) in neonates with peripherally inserted central venous catheters (PICCs) to guide development more effective strategies for prevention. Design. Prospective nested cohort study. Setting. Level III neonatal intensive care unit a community hospital. Methods. During randomized trial assess safety and efficacy prophylactic vancomycin-heparin catheter-lock solution prevention BSI PICCs, we performed...
Background. Although several trials of early dexamethasone therapy have been completed to determine if such would reduce mortality and chronic lung disease (CLD) in infants with respiratory distress, optimal duration side effects remain unknown. Purpose. The purpose this study was: 1) a 3-day course CLD increase survival without neonates who received surfactant for distress syndrome 2) adverse associated therapy. Design. This was prospective multicenter randomized trial comparing beginning...
The purpose of the study was to compare efficacy 10% povidone-iodine with that 0.5% chlorhexidine gluconate in 70% isopropyl alcohol for prevention peripheral intravenous catheter colonization neonates. This a multicenter, nonrandomized prospective tertiary neonatal intensive care setting which and were each used as antiseptic skin preparations over sequential 6-month periods. During first 6 months when povidoneiodine use 9.3% (38 408) catheters colonized. second use, occurred 4.7% (20 418,...
Six hundred fifty-four peripheral Teflon catheters in 303 pediatric intensive care unit patients were examined to determine complication rates and associated risk factors. Phlebitis, extravasation, bacterial colonization occurred at of 13%, 28%, 11%, respectively. Logistic regression factors that increased phlebitis revealed infusion hyperalimentation (odds ratio 2.9) or lorazepam 2.2) catheter location as the most important determinants risk. Age (≤1 year, odds 2.0), time situ (≤72 hours,...
To determine if an early, clinically detectable patent ductus arteriosus (PDA) was associated with pulmonary hemorrhage (PH) in infants who received rescue artificial surfactant therapy.This retrospective cohort study of 233 low birth weight (< or = 1700 g) therapy for respiratory distress syndrome compared antenatal and postnatal characteristics PH without PH. Pulmonary defined by onset bright red blood from the endotracheal tube quantities that resulted increased ventilatory support a new...
We reviewed charts of 261 children seen at Children's Hospital Wisconsin from 1957 to 1987 with culture-proven meningococcemia or meningococcal meningitis, and we analyzed trends in mortality disease severity for that interval. Overall case fatality was 10%, ranging 9% the period 1963, 16% 1980 (P = 0.15). The percent patients admitted severe increased 14% 38% 0.001). When stratified by severity, case-fatality rates did not change time. conclude technologic advances past 30 years had no...
Percutaneous endoscopic gastrostomy (PEG) tubes have been placed in children for more than 2 decades to provide nutrition those unable adequately and safely feed orally. Despite the well-documented success of PEG placement older children, there is only 1 published article documenting safety small infants. In all studies demonstrate major complication rate vary from 0.5% 17%. The objective this study was evaluate incidence acute complications medically complicated infants with a weight less 6...
During a prospective evaluation of intravenous therapy with peripheral Teflon catheters in children, we found 30 episodes phlebitis (10.4%). This rate is less than that reported adults. Catheter colonization was not related to phlebitic episodes, and catheter-related infections did occur. No patient's hospital course prolonged because phlebitis. Thirty percent the developed after catheter removed, premonitory symptoms were helpful predicting onset Factors associated an increased risk...