A5056393317- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Neonatal and fetal brain pathology
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Neonatal Health and Biochemistry
- Central Venous Catheters and Hemodialysis
- Antimicrobial Resistance in Staphylococcus
- Monoclonal and Polyclonal Antibodies Research
- Congenital Diaphragmatic Hernia Studies
- Bacterial Identification and Susceptibility Testing
- Healthcare Policy and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infant Development and Preterm Care
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Inflammasome and immune disorders
- Reproductive System and Pregnancy
- Respiratory Support and Mechanisms
- Infective Endocarditis Diagnosis and Management
- Blood disorders and treatments
- Pediatric health and respiratory diseases
University of Pennsylvania
2009-2025
Children's Hospital of Philadelphia
2013-2025
Regional Medical Center
2024
AtlantiCare
2024
Dominican University
2023
Philadelphia University
1992-2018
GTx (United States)
2012
Montefiore Medical Center
2009
University of Rochester
2005
University of Virginia
2005
Background Rapid antibiotic administration is known to improve sepsis outcomes, however early diagnosis remains challenging due complex presentation. Our objective was develop a model using readily available electronic health record (EHR) data capable of recognizing infant at least 4 hours prior clinical recognition. Methods and findings We performed retrospective case control study infants hospitalized ≥48 in the Neonatal Intensive Care Unit (NICU) Children's Hospital Philadelphia between...
Neonates who require a central venous catheter (CVC) for prolonged vascular access experience high rates of catheter-related bloodstream infection (CRBSI). Purpose. A multicenter randomized clinical trial was undertaken to ascertain the efficacy novel chlorhexidine-impregnated dressing (Biopatch Antimicrobial Dressing) on CVC sites neonates prevention tip colonization, CRBSI, and (BSI) without source. Setting. Six level III neonatal intensive care units. Patients Studied. admitted study...
In recent years, the increased prevalence of breastfeeding in conjunction with early discharge practices has risk for marked hyperbilirubinemia neonates. This resulted potential bilirubin brain injury affected infants. The purpose this study was to identify all infants >/=36 weeks' gestational age levels >25 mg/dL and evaluate them late evidence injury.We reviewed charts (from 1993-1996) who were readmitted hospital during first week life mg/dL. Readmission records signs encephalopathy....
Abstract Here we describe three subjects with mosaic genome‐wide paternal uniparental isodisomy (GWpUPD) each of whom presented initially overgrowth, hemihyperplasia (HH), and hyperinsulinism (HI). Due to the severity findings presence additional features, SNP array testing was performed, which demonstrated GWpUPD. Comparing these individuals 10 other live‐born reported in literature, predominant phenotype is that pUPD11 notable for a very high incidence tumor development. Our developed...
<h3>Objective</h3> Necrotising enterocolitis (NEC) is a major source of neonatal morbidity and mortality. The management infants with NEC currently complicated by our inability to accurately identify those at risk for progression disease prior the development irreversible intestinal necrosis. We hypothesised that integrated analysis clinical parameters in combination urine peptide biomarkers would lead improved prognostic accuracy population. <h3>Design</h3> Infants under suspicion having...
Abstract Objective Sepsis recognition among infants in the Neonatal Intensive Care Unit (NICU) is challenging and delays can result devastating consequences. Although predictive models may improve sepsis outcomes, clinical adoption has been limited. Our focus was to align model behavior with clinician information needs by developing a machine learning (ML) pipeline two components: (1) predict baseline risk (2) detect evolving (dynamic) due physiologic changes. We then compared performance of...
Background Necrotizing enterocolitis (NEC) is a major source of neonatal morbidity and mortality. Since there no specific diagnostic test or risk progression model available for NEC, the diagnosis outcome prediction NEC made on clinical grounds. The objective in this study was to develop validate new scoring systems automated staging prognostic forecasting. Study design A six-center consortium university based pediatric teaching hospitals prospectively collected data infants under suspicion...
In the ideal situation, evaluation for sepsis in young infant should include collection of multiple blood cultures before institution antibiotics. Unfortunately, some infants, it may not be possible to obtain more than a single culture at time initial evaluation. If this ultimately grows coagulase-negative staphylococci and has been treated with antimicrobial therapy interim, is often difficult determine whether positive represents true infection or contamination. Our data suggest that...