A5003446258- Renal Transplantation Outcomes and Treatments
- Advanced Proteomics Techniques and Applications
- Respiratory viral infections research
- Estrogen and related hormone effects
- Nanocluster Synthesis and Applications
- Infant Nutrition and Health
- Blood disorders and treatments
- Blood transfusion and management
- Cytomegalovirus and herpesvirus research
- Neutropenia and Cancer Infections
- Cancer Research and Treatments
- Neonatal Respiratory Health Research
- Viral-associated cancers and disorders
- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- Phagocytosis and Immune Regulation
- Cardiac and Coronary Surgery Techniques
- CNS Lymphoma Diagnosis and Treatment
- Hemostasis and retained surgical items
- Chronic Kidney Disease and Diabetes
- Glioma Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Vitamin D Research Studies
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
Stanford University
2006-2021
Queen Mary Hospital
2020
Palo Alto University
2017
Stanford Medicine
2016
<h3>Objective</h3> Necrotising enterocolitis (NEC) is a major source of neonatal morbidity and mortality. The management infants with NEC currently complicated by our inability to accurately identify those at risk for progression disease prior the development irreversible intestinal necrosis. We hypothesised that integrated analysis clinical parameters in combination urine peptide biomarkers would lead improved prognostic accuracy population. <h3>Design</h3> Infants under suspicion having...
Despite attractiveness of urine for biomarker discovery systemic and renal diseases, the confounding effect high abundance plasma proteins in urine, a lack optimization protein recovery methods are bottlenecks proteomics. Three were performed compared percentage yield, yield consistency, ease cost analysis: (i) organic solvent precipitation, (ii) dialysis/lyophilization, (iii) centrifugal filtration. Urine samples subjected to an immunoaffinity column deplete proteins. Difference gel...
Abstract Introduction Human urine is a complex matrix of proteins, endogenous peptides, lipids, and metabolites. The level any or all these components can reflect the pathophysiological status an individual especially kidney at time collection. naturally occurring urinary peptides which are thought to be product several proteolytic degradation processes may provide clinically useful biomarkers for different renal systemic diseases. Materials Methods To examine if specific differences in...
Abstract The goal of this study was to investigate whether vitamin D regulates the conversion cholesterol 27-hydroxycholesterol (27HC), an endogenous selective estrogen receptor modulator (SERM) that can act as a driver positive (ER+) breast cancer, particularly in post-menopausal women with low circulating levels. hypothesis active metabolite D, calcitriol, inhibit expression CYP27A1, synthesizing enzyme for 27HC, thereby decreasing concentration 27HC blood. Both and 25-hydroxyvitamin...
Abstract Background BRAF alterations frequently occur in pediatric low-grade gliomas. Previously, we showed that dabrafenib and trametinib (D+T) target MAPK pathway can mediate the antitumor effect a preclinical model of BRAF-mutant glioma (PMC5342782). Here, further investigate inhibitors on cancer cells tumor-infiltrating immune to maximize therapeutic efficacy malignant Methods Drug concentrations tumor, brain plasma were assessed by liquid chromatography-tandem mass spectrometry...