A5044179789- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Antimicrobial Resistance in Staphylococcus
- Mycotoxins in Agriculture and Food
- Fungal Plant Pathogen Control
- Plant-Microbe Interactions and Immunity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant nutrient uptake and metabolism
- Actinomycetales infections and treatment
- Gut microbiota and health
- Reproductive tract infections research
- Parasitic Diseases Research and Treatment
- Ombudsman and Human Rights
- Salmonella and Campylobacter epidemiology
- Mycobacterium research and diagnosis
- Legal Issues in South Africa
- Open Source Software Innovations
- Polish Law and Legal System
- Plant Disease Resistance and Genetics
- South Asian Studies and Conflicts
- Medical and Biological Ozone Research
- Green IT and Sustainability
- Immune cells in cancer
The University of Texas Health Science Center at San Antonio
2022-2024
University of Tennessee Health Science Center
2019-2021
University of Delhi
2012-2019
Candida auris is a multidrug-resistant yeast that causes wide spectrum of infections, especially in intensive care settings. We investigated C. prevalence among 102 clinical isolates previously identified as haemulonii or famata by the Vitek 2 system. Internal transcribed spacer region (ITS) sequencing confirmed 88.2% auris, and matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS) easily separated all related species, viz., (n = 90), 6), var. vulnera 1),...
Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. We studied the antifungal susceptibility of C. isolates (n = 350) from 10 hospitals India collected over a period 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations FKS1 analysed. CLSI testing six azoles, amphotericin B, three echinocandins, terbinafine, 5-flucytosine nystatin Screening for amino acid...
A new clonal strain of Candida auris is an emerging etiologic agent fungemia in Delhi, India. In 12 patients 2 hospitals, it was resistant to fluconazole and genotypically distinct from isolates South Korea Japan, as revealed by M13 amplified fragment length polymorphism typing.
Candida auris is an emerging multidrug-resistant yeast. So far, all but two susceptibility testing studies have examined ≤50 isolates, mostly with the CLSI method. We investigated and EUCAST MICs for 123 C. isolates eight antifungals evaluated various methods epidemiological cutoff (ECOFF) determinations. (in milligrams per liter) were determined using method M27-A3, E.Def 7.3. ANOVA analysis of variance Bonferroni's multiple-comparison test Pearson used on log2 (significance at P values...
Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this alarming as it exhibits resistance to azoles, amphotericin B caspofungin, which may lead clinical failure in patients. The multigene phylogeny amplified fragment length polymorphism typing methods report C. population clonal. Here, using whole genome sequencing analysis, we decipher for first time strains from four Indian hospitals were highly...
Azole resistance is an emerging problem in Aspergillus which impacts the management of aspergillosis. Here we report emergence and clonal spread to triazoles environmental fumigatus isolates India. A total 44 (7%) A. from 24 samples were found be triazole resistant. The isolation rate resistant was highest (33%) soil tea gardens followed by flower pots hospital garden (20%), beneath cotton trees rice paddy fields (12.3%), air wards (7.6%) admixed with bird droppings (3.8%). These strains...
ObjectivesAzole resistance in Aspergillus fumigatus isolates has been increasingly reported with variable prevalence worldwide and is challenging the effective management of aspergillosis. Here we report coexistence both TR34/L98H TR46/Y121F/T289A mechanisms azole-resistant A. (ARAF) originating from Tanzania, Africa.
Aspergillus fumigatus causes varied clinical syndromes ranging from colonization to deep infections. The mainstay of therapy diseases is triazoles but several studies globally highlighted variable prevalence triazole resistance, which hampers the management aspergillosis. We studied resistance in A. isolates during 4 years a referral Chest Hospital Delhi, India and reviewed scenario Asia Middle East. species (n = 2117) were screened with selective plates for azole resistance. included 45.4%...
What explains the origin, emergence, and persistence of Candida auris?Candida auris is a major emerging human fungal pathogen that was first reported in 2009 as an isolate from ear canal patient Japan [1].Since this initial report, C. has grown to represent "serious threat" healthcare settings, indicated by United States Centers for Disease Control (CDC) now on World Health Organization (WHO) priority list, described "most wanted" critical [2,3].However, many questions remain about spread,...
Candida auris is a multidrug-resistant yeast incriminated in wide spectrum of invasive infections, especially intensive care settings. The first draft genome sequence C. auris, VPCI 479/P/13, from case with fungemia was sequenced using the Illumina MiSeq platform. estimated size 12.3 Mb, 6,675 coding sequences.
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment invasive Candida auris infections, and observed among >90% all characterized isolates. In this work, native C. ERG11 allele in a previously fluconazole-susceptible isolate was replaced with alleles from three highly fluconazole-resistant isolates (MIC ≥256 mg/L), encoding amino acid substitutions VF125AL, Y132F, K143R, using Cas9-ribonucleoprotein (RNP) mediated transformation system....
Aspergillus terreus is emerging as an etiologic agent of invasive aspergillosis in immunocompromised individuals several medical centers the world. Infections due to A. are concern its resistance amphotericin B, vivo and vitro, resulting poor response antifungal therapy high mortality. Herein we examined a large collection molecularly characterized, geographically diverse isolates (n = 140) from clinical environmental sources India for occurrence cryptic species. The population structure...
ABSTRACT Invasive and allergic infections by Aspergillus flavus are more common in tropical subtropical countries. The emergence of voriconazole (VRC) resistance A. impacts the management aspergillosis, as azoles used first-line empirical therapy. We screened 120 molecularly confirmed isolates obtained from respiratory sinonasal specimens a chest hospital Delhi, India, for azole using CLSI broth microdilution (CLSI-BMD) method. Overall, 2.5% ( n = 3/120) had VRC MICs above epidemiological...
Summary Aspergillus fumigatus is a widespread opportunistic fungal pathogen causing an alarmingly high mortality rate in immunocompromised patients. Nosocomial infections by drug‐resistant A. strains are of particular concern, and there pressing need to understand the origin, dispersal long‐term evolution drug resistance this organism. The objective study was investigate diversity putative origins triazole from India. Eighty‐nine isolates, including 51 multiple resistant ( MTR ) isolates 38...