A5086389962- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Fungal Infections and Studies
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- CRISPR and Genetic Engineering
- Pneumonia and Respiratory Infections
- Vibrio bacteria research studies
- Respiratory viral infections research
- Antibiotic Use and Resistance
- Viral Infections and Vectors
- Gut microbiota and health
- Sepsis Diagnosis and Treatment
- COVID-19 diagnosis using AI
- RNA regulation and disease
- COVID-19 epidemiological studies
- Nosocomial Infections in ICU
- Influenza Virus Research Studies
- Plant Pathogens and Fungal Diseases
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Mycology
- Tuberculosis Research and Epidemiology
- Immune responses and vaccinations
Max Super Speciality Hospital
2014-2025
Max Healthcare
2016-2024
Devki Devi Foundation
2022
Hawaii Department of Health
2019
Post Graduate Institute of Medical Education and Research
2006-2019
Apollo Hospitals
2019
Sri Venkateswara Institute of Medical Sciences
2019
United States Department of State
2019
Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. We studied the antifungal susceptibility of C. isolates (n = 350) from 10 hospitals India collected over a period 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations FKS1 analysed. CLSI testing six azoles, amphotericin B, three echinocandins, terbinafine, 5-flucytosine nystatin Screening for amino acid...
Zygomycosis is an emerging infection worldwide. A study was conducted to understand its spectrum in the Indian scenario. All patients diagnosed for invasive zygomycosis at a tertiary care center north India from 2000-2004, were retrospectively analyzed. total of 178 cases (mean average 35.6 cases/year) diagnosed. Rhino-orbito-cerebral type (54.5%) commonest presentation followed by cutaneous (14.6%), disseminated (9.0%), and gastrointestinal (8.4%) zygomycosis. Renal pulmonary seen 6.7%...
In New Delhi, India, candidemia affected 15 critically ill coronavirus disease patients admitted to an intensive care unit during April-July 2020. Candida auris accounted for two thirds of cases; case-fatality rate was high (60%). Hospital-acquired C. infections in may lead adverse outcomes and additional strain on healthcare resources.
To identify the risk factors associated with Candida auris candidaemia, as this fungus now poses a global threat.We performed subgroup analysis of previously reported study 27 Indian ICUs. The clinical data candidaemia cases due to C. and other species were compared determine significant infection.Of 1400 earlier, 74 (5.3%) from 19 ICUs . duration ICU stay prior diagnosis was significantly longer in patients (median 25, IQR 12-45 days) non- group 15, 9-28, P < 0.001). Based on logistic...
In Brief Background: As fungal endophthalmitis is an emerging challenge, the study was carried out to determine prevalence and spectrum of agents causing from a single center, identify risk factors, correlate clinical course illness with involved. Methods: The microbiological records all diagnosed during January 1992 through December 2005 at tertiary center in India were reviewed retrospectively. During this period, treatment protocol patients pars plana vitrectomy, instillation intravitreal...
The ongoing pandemic of coronavirus disease 2019 (COVID-19) has overwhelmed healthcare facilities and raises an important novel concern nosocomial transmission Candida species in the intensive care units (ICUs).We evaluated incidence risk factors for development candidemia 2384 COVID-19 patients admitted during August 2020-January 2021 ICUs 2 hospitals (Delhi Jaipur) India. A 1:2 case-control matching was used to identify who did not develop as controls.A total 33 developed accounted overall...
The emergence of fluconazole resistance in Candida parapsilosis healthcare-associated infections has recently been increasingly reported. Antifungal susceptibility profiles and mechanisms C. (n = 199) from nine hospitals India collected over a period 3 years were studied. Further, clonal transmission fluconazole-resistant isolates different was investigated.Antifungal testing five azoles, amphotericin B 5-flucytosine performed by the CLSI microbroth dilution method. azole target ERG11 gene...
The variability of clinical course and prognosis COVID-19 highlights the necessity patient sub-group risk stratification based on data. In this study, data from a cohort Indian hospitalized patients is used to develop mortality prediction models. We analyzed set 70 parameters including physiological hematological for developing machine learning models identify biomarkers. also compared Wuhan cohort, role steroids. A bootstrap averaged ensemble Bayesian networks was learned construct an...
Candida glabrata infections are increasing worldwide and exhibit greater rates of antifungal resistance than those with other species. DNA mismatch repair (MMR) gene deletions, such as msh2Δ, in C. resulting a mutator phenotype have recently been reported to facilitate rapid acquisition resistance. This study determined the susceptibility profiles 210 isolates 10 hospitals India investigated impact novel MSH2 polymorphisms on mutation potential. No echinocandin- or azole-resistant strains no...
ABSTRACT Second wave of COVID-19 pandemic in India came with unexpected quick speed and intensity, creating an acute shortage beds, ventilators, oxygen at the peak occurrence. This may have been partly caused by emergence new variant delta. Clinical experience cases admitted to hospitals suggested that it is not merely a steep rise but also possibly case-profile different. study was taken up investigate differentials characteristics second versus those first wave. Records total 14398 (2020)...
The modulators of severe COVID-19 have emerged as the most intriguing features SARS-CoV-2 pathogenesis. This is especially true we are encountering variants concern (VOC) with increased transmissibility and vaccination breakthroughs. Microbial co-infections being investigated one crucial factors for exacerbation disease severity complications COVID-19. A key question remains whether early transcriptionally active microbial signature/s in patients can provide a window future susceptibility...
The rapid and early detection of infections antibiotic resistance markers is a critical challenge in healthcare. Currently, most commercial diagnostic tools for analyzing antimicrobial patterns pathogens require elaborate culture-based testing. Our study aims to develop rapid, accurate molecular system that can be used directly from culture, thereby introducing testing conjunction with culture tests reduce turnaround time guide therapy. PathCrisp assay, combination loop-mediated isothermal...
Stenotrophomonas maltophilia is a gram-negative opportunistic pathogen that causes respiratory, urinary and bloodstream infections. Due to rising prevalence of difficult treat S. infections, it considered as one the important pathogens in many regions, including India. Despite its importance public health, very few studies provide detailed characterization genomes clinical isolates maltophilia. In this study, we sequence six from tertiary healthcare centre Northern Along with culture...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous burden on the healthcare system worldwide as a consequence of its new emerging variants concern (VOCs) since late 2019. Elucidating viral genome characteristics and influence disease severity clinical outcome been one crucial aspects toward pandemic management. Genomic surveillance holds key to identify spectrum mutations vis-à-vis outcome. Here, in our study, we performed comprehensive analysis mutation...
The development of COVID 19 vaccines as an effort to mitigate the outbreak, has saved millions lives globally. However, vaccination breakthroughs have continuously challenged vaccines’ effectiveness and provided incentives explore facets holding potential alter vaccination-induced immunity protection from subsequent infection, especially VOCs (Variants Of Concern). We explored functional dynamics nasopharyngeal transcriptionally active microbes (TAMs) between unvaccinated SARS-CoV-2 infected...
Emergence of new SARS-CoV-2 VOCs jeopardize global vaccine and herd immunity safeguards. interactions with host microbiota might affect clinical course outcome. This longitudinal investigation involving Pre-VOC (Delta & Omicron) holo-transcriptome based nasopharyngeal microbiome at taxonomic levels followed by metabolic pathway analysis integrative host-microbiome interaction. showed enrichment
Co-infection with ancillary pathogens is a significant modulator of morbidity and mortality in infectious diseases. There have been limited reports co-infections accompanying SARS-CoV-2 infections, albeit lacking India specific study. The present study has made an effort toward elucidating the prevalence, diversity characterization co-infecting respiratory nasopharyngeal tract positive patients. Two complementary metagenomics based sequencing approaches, Respiratory Virus Oligo Panel (RVOP)...
The development of multiple vaccines against SARS-CoV-2 infection is an unprecedented milestone achieved globally. Immunization the mass population a rigorous process for getting pandemic under control, yet continuous challenges are being faced, one them breakthrough infections.
Dengue virus (DENV), known to cause viral infection, belongs the family Flaviviridae, having four serotypes (DENV1-4) that spreads by bite of Aedes aegypti mosquito. India has been suffering from dengue outbreaks annually with widespread epidemics prevalence all DENV serotypes. The diverse spectrum clinical manifestations in mild severe forms, makes need timely diagnosis and prompt treatment an essence. identification a host response signature serum can increase understanding pathogenesis...
The emergence of multiple variants concerns (VOCs) with higher number Spike mutations have led to enhanced immune escape by the SARS-CoV-2. With increasing vaccination breakthrough (VBT) infections, it is important understand possible reason/s infections.
Evolutionary studies on Dengue virus (DENV) in endemic regions are necessary since naturally occurring mutations may lead to genotypic variations or shifts serotypes, which future outbreaks. Our study comprehends the evolutionary dynamics of DENV, using phylogenetic, molecular clock, skyline plots, network, selection pressure, and entropy analyses based partial CprM gene sequences. We have collected 250 samples, 161 2017 89 2018. Details for samples were published our previous article that...