A5052373825- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Single-cell and spatial transcriptomics
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Mycorrhizal Fungi and Plant Interactions
- Immune responses and vaccinations
- Long-Term Effects of COVID-19
- CRISPR and Genetic Engineering
- Drug Transport and Resistance Mechanisms
- RNA regulation and disease
- Weed Control and Herbicide Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Cell Image Analysis Techniques
- Agricultural pest management studies
- Biological Control of Invasive Species
- Allelopathy and phytotoxic interactions
- Bacterial biofilms and quorum sensing
- Insect Pest Control Strategies
- Plant pathogens and resistance mechanisms
- Turfgrass Adaptation and Management
Institute of Genomics and Integrative Biology
2021-2025
Academy of Scientific and Innovative Research
2021-2025
Jawaharlal Nehru University
2024
University of Botswana
2013-2016
Egerton University
2002
University of Nairobi
1985
The modulators of severe COVID-19 have emerged as the most intriguing features SARS-CoV-2 pathogenesis. This is especially true we are encountering variants concern (VOC) with increased transmissibility and vaccination breakthroughs. Microbial co-infections being investigated one crucial factors for exacerbation disease severity complications COVID-19. A key question remains whether early transcriptionally active microbial signature/s in patients can provide a window future susceptibility...
Dengue virus (DENV) infection manifests a wide spectrum of clinical outcomes, ranging from mild fever to severe and potentially fatal disease, yet the factors driving this variability remain poorly understood. This study aims unravel relationship between manifestations dengue genetic diversity virus, providing insights into genomic disease severity. To achieve this, serum samples were collected during outbreak in National Capital Region-Delhi, India, June November 2023. Serotyping RNA...
Introduction Despite numerous efforts to describe COVID-19's immunological landscape, there is still a gap in our understanding of the virus's infections after-effects, especially recovered patients. This would be important understand as we now have huge number global populations infected by SARS-CoV-2 well variables inclusive VOCs, reinfections, and vaccination breakthroughs. Furthermore, single-cell transcriptome alone often insufficient complex human host immune landscape underlying...
Emergence of SARS-CoV-2 VOCs at different time points through COVID-19 pandemic raised concern for increased transmissibility, infectivity and vaccination breakthroughs.1567 international travellers plus community transmission cases were analysed mutational profile VOCS, that led to notable waves in India, namely Alpha, Delta, Omicron. Spike mutations Linkage Disequilibrium investigated potential impact on structural functional changes Spike-ACE2.ORF1ab spike harboured diverse signatures...
Seeds of three cowpea cultivars namely Black eye, ER 7 and Tswana obtained from the Department Agriculture Research, Gaborone were tested for presence seed-borne fungi, their possible control in vitro using locally available fungicides. Four hundred fifty seeds each cultivar disinfected with 2% sodium hypochlorite solution 10 min washed times sterile distilled water before placing them PDA plates (5 seeds/9 cm Petri plate), incubated at 22±2o C 12 hour under continuous light dark. A total...
Introduction Several efforts have been made to describe the complexity of T cell heterogeneity during COVID-19 disease; however, there remain gaps in our understanding terms granularity within. Methods For this attempt, we performed a single-cell transcriptomic analysis 33 individuals (4 healthy, 16 positive patients, and 13 recovered individuals). Results We found CD8 + cell-biased lymphopenia patients compared healthy individuals. also an optimal Th1/Th2 ratio, indicating effective immune...
The effect of three different grain spawns and two substrate sterilization methods on the spawn quality yield a hybrid Pleurotus ostreatus x P. florida (Po Pf) was studied maize cobs supplemented with 20% wheat bran 2% gram flour in low technological mushroom house at Botswana College Agriculture, Sebele. Sorghum grains proved to be better mycelium carriers (5.25, 7 days, 12 days 75.4%) over (2.45, 17 16 53.55%) barley (3.46, 14 13 55.24%) terms growth vigor, colonization time, running time...
Natural anti-oxidants are the good source for scavenging excess of free radicals generated in body after oxidative stress. The present study is aimed at vitro evaluation radical potentials two extracts prepared from samples a truffle, Kalaharituber pfeilii collected Kalahari desert Botswana. These water extract (WTE) and methanol (MTE).First all, DPPH-TLC-Semi quantitative assay was used to assess anti-oxidant properties. This experiment showed that lower concentration, WTE better results...
Seeds of three sorghum varieties namely Segaolane, Phofu and SNK-3939 obtained from different locations in Botswana were used for detection seed-borne fungi their possible control by botanical fungicides. Four hundred seeds each variety surface sterilized with 2% sodium hypochlorite solution before placing them on moist blotter (10 seeds/90cm Petri plate), incubated seven days at 22±2 o C 12 hours under continuous light alternating darkness. Eight recovered. These Aspergillus flavus, A....