A5043732229- Sarcoma Diagnosis and Treatment
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Oral and Maxillofacial Pathology
- Viral gastroenteritis research and epidemiology
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Cystic Fibrosis Research Advances
- Tumors and Oncological Cases
- Medical Imaging and Pathology Studies
- Virology and Viral Diseases
- Respiratory Support and Mechanisms
- Neuroblastoma Research and Treatments
- Genomics and Chromatin Dynamics
- Gastrointestinal Tumor Research and Treatment
- Cholesterol and Lipid Metabolism
- Vector-Borne Animal Diseases
- Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Viral-associated cancers and disorders
- Pneumonia and Respiratory Infections
- Advanced Thermodynamic Systems and Engines
- Congenital Anomalies and Fetal Surgery
- Viral Infections and Immunology Research
- Respiratory viral infections research
Lund University
2019-2024
Skåne University Hospital
2017-2020
Ziekenhuis Oost-Limburg
2012-2013
University of Manitoba
1993-2003
Children's Hospital of Winnipeg
1993
KU Leuven
1990-1992
Nederlandse Vereniging voor Kindergeneeskunde
1992
<b>Objective</b> To evaluate the effectiveness of rotavirus vaccination among young children in Belgium. <b>Design</b> Prospective case-control study. <b>Setting</b> Random sample 39 Belgian hospitals, February 2008 to June 2010. <b>Participants</b> 215 admitted hospital with gastroenteritis confirmed by polymerase chain reaction and 276 age matched controls. All were an eligible have received (that is, born after 1 October 2006 aged ≥14 weeks). <b>Main outcome measure</b> Vaccination status...
Inflammatory leiomyosarcoma is a soft-tissue tumor resembling conventional leiomyosarcoma, but with prominent intrinsic inflammatory component. Previous studies have suggested that differs genetically from in-depth analyses are lacking. Here we provide comprehensive picture of the genome and transcriptome by combining cytogenetic, single-nucleotide polymorphism array, mRNA-sequencing, whole-exome sequencing data. The results show has specific genetic profile characterized near-haploidization...
Abstract Well-differentiated liposarcoma (WDLS) displays amplification of genes on chromosome 12 (Chr12) in supernumerary ring or giant marker chromosomes. These structures have been suggested to develop through chromothripsis, followed by circularization and breakage-fusion-bridge (BFB) cycles. To test this hypothesis, we compared WDLSs with Chr12 rod-shaped chromosomes rings. Both types amplicons share the same spectrum structural variants (SVs), show higher SV frequencies than...
The aim of the study was to evaluate diagnostic utility fine needle aspiration (FNA) cytology and core biopsies (CNBs) in a series primary soft tissue bone lesions test possible system for reporting results FNA lesion.This retrospective encompassed 828 lesions, analysed with FNA, CNB and/or surgical specimen order perform sensitivity/specificity as well accuracy analyses. then used cytopathology six categories risk malignancy each category calculated.With malignant diagnosis defined positive...
The dermatofibrosarcoma protuberans family of tumors (DPFT) comprises cutaneous soft tissue neoplasms associated with aberrant PDGFBR signaling, typically through a COL1A1-PDGFB fusion. aim the present study was to obtain better understanding chromosomal origin this fusion and assess spectrum secondary mutations at chromosome nucleotide levels. We thus investigated 42 tumor samples from 35 patients using banding, fluorescence in situ hybridization, single polymorphism arrays, and/or...
Abstract Myxoid liposarcoma (MLS) is molecularly characterized by fusions involving the DDIT3 gene in chromosome band 12q13; fusion partner FUS 16p11 90–95% of cases and EWSR1 22q12 remaining 5–10%. Hence, molecular studies, often fluorescence situ hybridization (FISH) for rearrangement, are useful establishing a correct diagnosis. Although all MLS tumors should have fusions, it important to be aware reasons potential false‐negative results. We here present case that was negative FISH ,...
The C syndrome of multiple congenital anomalies is described in a male infant with pseudohypoaldosteronism. association these 2 rare autosomal recessive conditions discussed.
Morphologic and immunohistochemical analysis of preoperative core needle biopsies (CNB) is important in the management patients with soft tissue bone tumors (STBTs). Most SBTB subtypes have more or less extensive DNA copy number aberrations (CNA), potentially providing useful diagnostic information. To evaluate technical feasibility single nucleotide polymorphism (SNP) array usefulness profiles, we studied CNBs from 171 suspected STBTs. SNP could be performed on 168 (98%) samples. The CNA...
Near-haploidization, that is, loss of one copy most chromosomes, is a relatively rare phenomenon in tumors, but enriched among certain soft tissue sarcomas, including undifferentiated pleomorphic sarcoma (UPS). Presumably, near-haploidization can arise through many mechanisms. This study aimed to identify gene rearrangements could cause near-haploidization. We here present two UPS which was an early event, identified single nucleotide polymorphism (SNP) array analysis. One the cases studied...
ABSTRACT Objective Fine‐needle aspiration cytology (FNAC) from bone lesions has been proven to be a useful diagnostic tool but lacks standardisation. The aim of the study was evaluate utility FNAC as basis propose and test reporting system for cytopathology. Methods This retrospective is based on patients with lesions, that were approached by at Skåne University Hospital, Sweden between 2015 2023. performance measured sensitivity, specificity accuracy analyses. All diagnoses then distributed...
El tiempo inspiratorio previo a la realizacion de una maniobra espiratoria forzada maxima (FEM) es variable que no ha sido completamente estudiada en Fibrosis Quistica (FQ). objetivo este estudio fue evaluar hipotesis ninos con FQ tendrian mayores volumenes y flujos espiratorios forzados al disminuir duracion del inspiratorio. Se estudiaron 16 FQ, etapa estable, sin haber presentado exacerbacion respiratoria los ultimos dos meses, (10 hombres), edad 11,9 ± 0,7 anos (promedio ES), un FEV1...
A 15-month-old boy with a 2-month history of watery diarrhoea presented cachexia, hypokalaemia, hypochloraemia and metabolic acidosis. During 2-week investigation period infection, celiac disease cystic fibrosis were excluded trial therapy antibiotics, probiotics dietary measures proved unsuccessful. This led to the suspected diagnosis vasoactive intestinal polypeptide (VIP)-secreting tumour diarrhoea, achlorhydria (WDHA)-syndrome. MRI showed an infrarenal mass infiltrating neuroforamen,...