A5081578708- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Neuroscience and Neuropharmacology Research
- Pain Management and Placebo Effect
- Pharmacological Effects of Natural Compounds
- Nicotinic Acetylcholine Receptors Study
- Planarian Biology and Electrostimulation
- Neuropeptides and Animal Physiology
- Cardiac Ischemia and Reperfusion
- Anesthesia and Sedative Agents
- Muscle metabolism and nutrition
- Vitamin D Research Studies
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neural Engineering
- Natural product bioactivities and synthesis
- Cannabis and Cannabinoid Research
- Hormonal Regulation and Hypertension
- Sleep and Wakefulness Research
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Cardiac Fibrosis and Remodeling
University of Cincinnati Medical Center
2020-2024
University of Cincinnati
2022
The Ohio State University
2016-2020
Cincinnati Children's Hospital Medical Center
2019
Maladaptive changes of nerve injury-associated genes in dorsal root ganglia (DRGs) are critical for neuropathic pain genesis. Emerging evidence supports the role long noncoding RNAs (lncRNAs) regulating gene transcription. Here we identified a conserved lncRNA, named injury-specific lncRNA (NIS-lncRNA) its upregulation injured DRGs exclusively response to injury. This was triggered by injury-induced increase DRG ELF1, transcription factor that bound NIS-lncRNA promoter. Blocking this...
Duchenne muscular dystrophy (DMD) is an X-linked inherited disease due to dystrophin deficiency causing skeletal and cardiac muscle dysfunction. Affected patients lose ambulation by age 12 usually die in the second third decades of life from respiratory failure. Symptomatic treatment includes use anti-inflammatory corticosteroids, which are associated with side effects including weight gain, osteoporosis, increased risk cardiovascular disease. Novel options include blockade...
Combined treatment with an angiotensin-converting enzyme inhibitor and a mineralocorticoid receptor (MR) antagonist improved cardiac skeletal muscle function pathology in mouse model of Duchenne muscular dystrophy. MR is present limb respiratory muscles functions as steroid hormone receptor.The goals the current study were to compare efficacy specific eplerenone non-specific spironolactone, both combination lisinopril.Three groups n=18 dystrophin-deficient, utrophin-haploinsufficient male...
Mineralocorticoid receptor antagonists added to angiotensin converting enzyme inhibitors have shown preclinical efficacy for both skeletal and cardiac muscle outcomes in young sedentary dystrophin-deficient mdx mice also haploinsufficient utrophin, a Duchenne muscular dystrophy (DMD) model. The genotypic DMD model has mild pathology, making non-curative therapeutic effects difficult distinguish at baseline. Since the benefit of mineralocorticoid been translated patients, it is important...
Cannabinoid receptors have been identified as potential targets for analgesia from studies on animal physiology and behavior, human clinical trials. Here, we sought to improve translational understanding of the mechanisms cannabinoid-mediated peripheral analgesia. Human lumbar dorsal root ganglia were rapidly recovered organ donors perform physiological anatomical investigations into cannabinoids mediate at level nervous system. Anatomical characterization in situ gene expression...
The anterior cingulate cortex is a limbic region associated with the emotional processing of pain. How neuropathic and inflammatory pain models alter neurophysiology specific subsets neurons in remains incompletely understood. Here, we used GRM2 Cre :tdtomato reporter mouse line to identify population pyramidal selectively localized layer II/III murine cortex. GRM2encodes group II metabotropic glutamate receptor subtype 2 which possesses analgesic properties human models, although its...
Corticosteroid receptors, including mineralocorticoid receptor (MR) and glucocorticoid (GR), play important roles in inflammatory pain the dorsal root ganglion (DRG). Although it is widely known that activating GR reduces pain, has recently been shown MR activation contributes to neuronal excitability rodent studies. Moreover, little about translation of this work humans, or mechanisms through which corticosteroid receptors regulate pain. expression human mouse DRGs was characterized....