A5083177068- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Drug Transport and Resistance Mechanisms
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Epilepsy research and treatment
- Anesthesia and Sedative Agents
Cincinnati Children's Hospital Medical Center
2018-2024
University of Cincinnati Medical Center
2023
University of Cincinnati
2018
The mechanistic target of rapamycin (mTOR) pathway has been implicated in promoting epileptogenesis animal models acquired epilepsy, such as posttraumatic epilepsy (PTE) following traumatic brain injury (TBI). However, the specific anatomical regions and neuronal populations mediating mTOR's role are not well defined. In this study, we tested hypothesis that mTOR activation dentate gyrus granule cells promotes death, mossy fiber sprouting, PTE controlled cortical impact (CCI) model TBI.
Status epilepticus (SE) is a life-threatening medical emergency with significant morbidity and mortality. SE associated robust sustained increase in serum glucocorticoids, reaching concentrations sufficient to activate the dense population of glucocorticoid receptors (GRs) expressed among hippocampal excitatory neurons. Glucocorticoid exposure can neuron excitability; however, whether activation GRs during exacerbates seizure severity remains unknown. To test this, viral strategy was used...