A5077012792- Dementia and Cognitive Impairment Research
- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Cancer-related cognitive impairment studies
- Mitochondrial Function and Pathology
- Brain Metastases and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer survivorship and care
- Acute Ischemic Stroke Management
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Health disparities and outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Ocular Diseases and Behçet’s Syndrome
- Stroke Rehabilitation and Recovery
- Neurogenetic and Muscular Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Cerebral Palsy and Movement Disorders
- Long-Term Effects of COVID-19
- Migraine and Headache Studies
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2016-2025
Universidade do Porto
2014-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018-2024
Hospital de São Sebastião
2012-2021
Instituto de Saúde
2020
Instituto Nacional de Neurología y Neurocirugía
2001-2016
Universitat Pompeu Fabra
2015
Hospital General Universitario Morales Meseguer
2010
There is limited and inconsistent information on the clinical determinants of cognitive impairment (CI) in multiple sclerosis (MS).The aim this study was to compare prevalence profile CI across MS disease subtypes assess its determinants.Cognitive performance assessed through Brief Repeatable Battery Stroop test consecutive patients with referred six Italian centers. defined as ⩾ 2 domains.A total 1040 were included, 167 clinically isolated syndrome (CIS), 759 relapsing remitting (RR), 74...
Cognitive impairment is a common and disabling feature of multiple sclerosis (MS), but precise characterization cognitive phenotypes in patients with MS lacking.To identify clinical cohort to characterize their magnetic resonance imaging (MRI) features.This multicenter cross-sectional study consecutively screened clinically stable healthy control individuals at 8 centers Italy from January 1, 2010, October 31, 2019. Patients who were not using psychoactive drugs had no history other...
Importance: Epidemiological data on hereditary cerebellar ataxia (HCA) and spastic paraplegia (HSP) are scarce.Objective: To present the prevalence distribution of HCA HSP in Portugal.
Abstract Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder caused by expansion of unstable ATTCT repeat. SCA10 has been described as a pure cerebellar syndrome accompanied seizures and recognized only in families Mexican origin. We describe clinical molecular findings 18 patients four with SCA10. Affected individuals had average age at onset 26.7 years (range 14–44 years) repeats ranging from 920 to 4,140 repeats. could not detect significant anticipation or...
The increase in average life expectancy increases the risk of illness and frailty elderly, especially cognitive arena. This study has objective to estimate prevalence incidence impairment, a representative sample 65 85 years old followed for mean period 6-years.
Sequential testing with brief cognitive tools has been recommended to improve screening and monitoring, however the few available still depend on an external evaluator periodic visits. We developed a self-administered computerized test intended for longitudinal (Brain Track). The can be performed from home computer is composed of several subtests, expected evaluate different domains, all including random elements minimize learning effects. An initial (A) refined version (B) were applied...
Abstract Objectives We aim to investigate cognitive phenotype distribution and MRI correlates across pediatric‐, elderly‐, adult‐onset MS patients as a function of disease duration. Methods In this cross‐sectional study, we enrolled 1262 238 healthy controls, with neurological assessments. A subset 222 92 controls underwent 3T‐MRI scan for brain atrophy lesion analysis. Multinomial probabilistic models identified likelihood belonging phenotypes (“preserved‐cognition,” “mild verbal...
Background: Patients with paediatric-onset multiple sclerosis (POMS) could be at an increased risk for cognitive impairment (CI), given the potential harmful effects of disease activity in neurodevelopment. However, there is scarce information on their long-term outcomes. Objective: To compare prevalence and profile CI between adults a history POMS those classic, adult-onset (AOMS). Methods: Cognitive performance was assessed through Brief Repeatable Battery (BRB) Stroop Test consecutive...
Background: Cognitive training has been playing an increasing role in the treatment of patients with cognitive deficits. This type intervention, namely its intensity, can be optimized by incorporating information technology-based systems.
Abstract Dominant ataxias show wide geographic variation. We analyzed 108 dominant families and 123 sporadic ataxia patients from Mexico for mutations causing SCA1–3, 6–8, 10, 12, 17 DRPLA. Only 18.5% of remained undiagnosed; SCA2 accounted half (45.4%), followed by SCA10 (13.9%), SCA3 (12%), SCA7 (7.4%), SCA17 (2.8%). None had SCA1, 6, 8, 12 or Among cases, 6 (4.9%), 2 (1.6%). In the we identified individuals with rare (CAG) 33 allele, whom showed early onset ataxia. The distribution in...
Background: Vascular disease may play an important role in the epidemiology of dementia countries with high stroke incidence, such as Portugal. Objective: To assess prevalence and etiology cognitive impairment a population-based cohort from Methods: Individuals ≥55 years (n = 730) EPIPorto were assessed using Mini-Mental State Examination Montreal Cognitive Assessment. Those scoring below age-/education-adjusted cutoff points further evaluated to identify or mild (MCI) define its most common...
Computerized cognitive tests have the potential to cost-effectively detect and monitor impairments thereby facilitate treatment for these conditions. However, relatively few of been validated in a variety populations. Brain on Track, self-administered web-based test, has previously shown good ability differentiate between healthy individuals patients with impairment Portuguese The objective this study was validate differential evaluate usability Track Swedish memory clinic setting....
Objectives To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of deficits with brain magnetic resonance imaging (MRI) volumetric data. Materials methods In a multicenter cross-sectional study, we recruited consecutive patients PPMS as well age, sex, education level-matched healthy controls (HC). All participants underwent neuropsychological (NP) assessment, MRI was performed for analysis lesion load, subcortical GM volumes,...
(1) Background: In an ageing society, social relationships may benefit cognitive performance with impact on the health of older people. This study aims to estimate effect different support sources risk impairment in a sample Portuguese (2) Methods: From EpiPorto cohort study, we followed participants 60 85 years (N = 656) between 2009 and 2015 (4.63 mean follow-up). The participants’ perception from family, friends significant others was evaluated. Cox’s regression models were used...
Objective. To determine the frequency of central nervous system (CNS) tumors in first fifty years National Institute Neurology and Neurosurgery Mexico Manuel Velasco Suárez (Instituto Nacional de Neurología y Neurocirugía México, INNN) from 1965 to 2014. Materials methods. A total 16 116 institutional records CNS were analyzed. The distribution evaluated by tumor type, patient age gender. annual relationship between surgical discharges (SD) over last 20 was estimated. Results. frequencies...
Repeated measurements could be helpful to identify patients with early cognitive decline. We compare the variation of performance over one year in mild impairment (MCI) and healthy individuals using Brain on Track self-applied computerized test (BoT). The study was initiated 30 probable MCI 377 controls from a population-based cohort, who performed BoT home every three months for year. scores were compared linear mixed-effects model. All participants increased their first tests, after 120...
Abstract Background The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient may be disappearing in Northern hemisphere. few previous studies performed Portugal have reported a lower than average for Western Europe. aim this study is to estimate MS Entre Douro e Vouga region, Portugal. Methods overlapping sources were used ascertain all cases from reference population: records hospitals region neighbouring regions; diagnostic databases primary care...
Prostate cancer (PCa) is the most prevalent among men, and psychological symptoms may affect many patients. This study aims to describe prevalence of probable anxiety depression before PCa treatments after one year identify sociodemographic clinical factors associated with these outcomes. Between February 2018 March 2020, 292 patients recently diagnosed were recruited at Instituto Português de Oncologia—Porto. The Hospital Anxiety Depression Scale (HADS) was used define (cutoff = 11)....