A5009421195- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Virology and Viral Diseases
- Multiple Myeloma Research and Treatments
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Chemotherapy-related skin toxicity
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- AI in cancer detection
- Lymphatic Disorders and Treatments
- Management of metastatic bone disease
- ATP Synthase and ATPases Research
- Colorectal Cancer Surgical Treatments
Daping Hospital
2019-2025
Army Medical University
2019-2025
Renji Hospital
2021
Memorial Sloan Kettering Cancer Center
2019
Tianjin Medical University Cancer Institute and Hospital
2014
Tianjin Medical University
2014
University of Maryland, Baltimore
2013
U-M Rogel Cancer Center
2013
There is no consensus regarding whether primary tumour resection (PTR) should be performed in non-small cell lung cancer (NSCLC) patients with unexpected pleural dissemination (PD) discovered at thoracotomy. Consecutive NSCLC surgically confirmed PD were retrospectively enrolled from two high-volume centres between January 2016 and December 2023. Patients divided into the exploratory thoracotomy (ET) group. PTR included wedge resection, segmentectomy lobectomy. ET group received biopsy only....
<title>Abstract</title> <bold>Background:</bold> Cancers of the lower esophagus and esophagogastric junction (EGJ) are highly aggressive with poor prognoses. Minimally invasive Ivor–Lewis surgery (MIIL) is preferred, but anastomotic leakage remains a critical complication. This study introduces novel double-layered scallop-shaped anastomosis (DLSSA) technique compares its outcomes circular stapled (CSEA). <bold>Methods:</bold> From April 2016 to February 2023, 117 patients distal esophageal...
Abstract Background Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased serum albumin level considered predictive of AL, however, its impact on AL incidence in patients treated neoadjuvant chemotherapy (NCT) followed by minimally invasive (MIE) not well defined. Methods The data 318 consecutive esophageal cancer who underwent MIE were collected retrospectively from January 2021 to December 2021. perioperative was detected and...
Metastasis and malignant proliferation are major obstacles to the treatment of oesophageal squamous cell carcinoma (ESCC), UTP14A is associated with poor prognosis in ESCC.However, its mechanisms have not been fully elucidated.The TCGA GEO databases were used identify candidate target genes possible downstream targets.Then, effects determined vitro vivo through knockdown overexpression techniques, mechanism was explored.UTP14A significantly higher tumour tissue ESCC patients than normal...
<h3>Background</h3> Several immune checkpoint inhibitors (ICIs), represented by programmed cell death protein 1 (PD-1)/programmed ligand (PD-L1) antibodies, have been approved for treatment of various malignant tumors (including advanced esophageal cancer) worldwide, and previous studies confirmed that they can significantly improve overall survival.<sup>1</sup> However, there has limited research on the use ICIs as neoadjuvant therapy patients with cancer. Toripalimab is a humanized IgG4...
Summary There is growing focus on the relationship between surgical start time and postoperative outcomes. However, extent to which operation affects oncological outcomes of patients undergoing esophagectomy has not previously been studied. The purpose this retrospective study was investigate potential effect short- long-term for who underwent thoracoscopic–laparoscopic McKeown esophagectomy. From September 2009 June 2019, a total 700 consecutive suffering from esophageal cancer in...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive and lethal cancers lacking valid prognostic biomarkers. As an essential component a large ribonucleoprotein complex, U Three Protein 14a (UTP14a) might play important roles in human tumorigenesis. However, clinical significance functions UTP14a ESCC still remain unclear.From September 2009 to August 2015, 210 patients with thoracic esophagus underwent thoracoscopic esophagectomy our institute. The corresponding tissue...
Lymphovascular invasion (LVI) is reported to be a potential prognostic predictor in esophageal squamous cell carcinoma (ESCC) patients.To investigate the value of LVI ESCC node-negative patients after minimally invasive esophagectomy (MIE).1406 consecutive who underwent MIE were reviewed retrospectively. After exclusion, 880 enrolled, and 298 used for further analysis. The Kaplan-Meier method was examine survival difference. Univariate multivariate analyses performed identify predictors.LVI...
The prognostic value of high body mass index (BMI) in patients with esophageal squamous cell carcinoma (ESCC) is still controversial.To evaluate the impact BMI on postoperative complications and survival after minimally invasion esophagectomy (MIE) for ESCC patients.Three hundred fourteen consecutive were used to analyze potential association between survival.Patients divided into two groups. There was no significant difference low groups terms complications, including respiratory disease (p...
Clinical benefits of neoadjuvant Anlotinib for locally advanced esophageal squamous cell carcinoma (ESCC) remains unclear. This study evaluated the efficacy and safety plus chemotherapy followed by minimally invasive esophagectomy (MIE) treatment patients with ESCC.Patients ESCC were randomly assigned to combined (Anlotinib group) or chemoradiotherapy alone (nCRT an allocation ratio 1:1. The primary endpoint was R0 surgical resection rate. Secondary endpoints included postoperative...
Background: Lymph nodes along the left recurrent laryngeal nerve (LRLN) is thought to be highly involved in esophageal cancer. Given unique anatomical positioning of nerve, performing lymphadenectomy this region requires advanced techniques within limited working space. Meanwhile, high incidence morbidity and mortality associated with lymphadenectomy. Although several methods have been applied reduce technical requirement postoperative complication, optimal method remains controversial....
Background: This prospective cohort study, conducted at a high-volume esophageal cancer center from July 2019 to 2022, aimed investigate the link between right gastroepiploic artery (RGEA) length and anastomotic leakage (AL) rates following minimally invasive esophagectomy (MIE). Real-world data on stomach blood supply in Chinese population were examined. Materials Methods: A total of 516 cases enrolled, categorized into two groups based Youden index-determined optimal cut-off value for...
4078 Background: Although neoadjuvant chemoradiotherapy is evolved into standard-of-care treatment in locally advanced esophageal cancer (EC) patients (pts), nearly half of pts experience relapse and death within 5 years. It therefore important to establish novel effective strategies for further improve survival. With successful unresectable squamous cell carcinoma (ESCC) with PD-1/PD-L1 inhibitors, which are expected provide better benefits resectable ESCC preoperatively. However, owing...
To identify the optimal number of lymph nodes dissected during esophagectomy following neoadjuvant therapy for carcinoma esophagus by using Surveillance, Epidemiology and End Results Registry (SEER) database.Patients who underwent Chemoradiotherapy (nCRT) plus with EC from 2001-2016 were analyzed retrospectively in SEER database. We correlation between lymphadenectomy count nodal stage migration overall survival (OS) a binary logistic regression model Cox proportional hazards regression. The...