A5101894456- PI3K/AKT/mTOR signaling in cancer
- Healthcare Systems and Public Health
- Retinal Imaging and Analysis
- Intensive Care Unit Cognitive Disorders
- Optical Coherence Tomography Applications
- Cervical Cancer and HPV Research
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- HER2/EGFR in Cancer Research
- Congenital Heart Disease Studies
- COVID-19 Clinical Research Studies
- Bladder and Urothelial Cancer Treatments
- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Advanced Breast Cancer Therapies
National Eye Institute
2022
Mount Sinai Hospital
2020-2021
Icahn School of Medicine at Mount Sinai
2020-2021
Northwestern University
2020
Elmhurst Hospital Center
2020
Baylor College of Medicine
2002
Abstract On May 24, 2019, the FDA granted regular approval to alpelisib in combination with fulvestrant for postmenopausal women, and men, hormone receptor (HR)-positive, HER2-negative, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on after endocrine-based regimen. Approval was based SOLAR-1 study, a randomized, double-blind, placebo-controlled trial of...
Abstract Aims While right ventricular (RV) dysfunction is associated with worse prognosis in co‐morbid pulmonary hypertension and heart failure preserved ejection fraction (PH‐HFpEF), the mechanisms driving RV are unclear. We evaluated extent clinical correlates of diffuse myocardial fibrosis PH‐HFpEF, as measured by cardiovascular magnetic resonance‐derived extracellular volume (ECV). Methods results prospectively enrolled participants PH‐HFpEF ( n = 14), arterial (PAH; 13), controls 8)....
Optical coherence tomography angiography (OCTA) is an emerging non-invasive technique for imaging the retinal vasculature. While there are many promising clinical applications OCTA, determination of image quality remains a challenge. We developed deep learning-based system using ResNet152 neural network classifier, pretrained ImageNet, to classify images superficial capillary plexus in 347 scans from 134 patients. Images were also manually graded by two independent graders as ground truth...
Overexpression of epidermal growth factor receptor (EGF-R) is associated with increased malignant potential and correlates poor clinical outcome in head neck cancer. Therefore, inhibition the EGF-R pathway provides an ideal target for molecular therapy. We examined vitro vivo effects PKI166, orally administered inhibitor, on 2 human squamous cell carcinoma oral cavity lines, Tu159 MDA1986.Basic science, laboratory investigation.For Western blotting, MDA1986 cells were pretreated 1 hour then...